目的 評估非小細胞肺癌患者中癌癥相關性乏力的發生情況及其與患者臨床病理特征和生存期之間的相互關系。 方法 應用簡明疲勞量表中文版評估2008年12月－2009年12月間收治的72例初治肺癌患者，入組患者均完成根治性手術及術后生存隨訪。 結果 72例早期非小細胞肺癌患者中，無乏力9例（12.5%），輕度乏力48例（66.7%），中度乏力15例（20.8%），重度乏力0例（0%），乏力總體發生率為87.5%。乏力指數與患者的年齡、性別、吸煙史均無相關性，與患者的體力狀況評分（ECOG PS）、TNM分期呈正相關，與中位生存期呈負相關，均有統計學意義（P＜0.05）。 結論 癌癥相關性乏力作為非小細胞肺癌患者中普遍存在的一種癥狀，不僅能夠反映患者當時的主觀感受和生活狀況，還可能是判斷患者術后病理分期及最終總生存期的預測因素。
Objective To evaluate the effects of neuromuscular blocking agents( NMBAs) in acute respiratory distress syndrome( ARDS) . Methods Randomized controlled trials( RCTs) and non-RCTs were recruited fromPubMed( 1966. 1-2012. 3) , EMBASE( all the years) , Cochrane Library( all the years) and CNKI Database( 1979-2012) . Related published studies and attached references were hand searched. All the RCTs and non-RCTs ( including prospective and retrospective studies) about NMBAs for the patients with ARDS were included. Then a meta-analysis and statistic descriptions for RCTs( using RevMan5. 0 software) and non-RCTs were performed. Jadad and NEWCASTLE-OTTAWA QUALITY ASSESSMENT SCALE were used to assess the methodological quality of the included RCTs and non-RCTs. Results Three eligible RCTs and four non-RCTs were enrolled. The quality of the included trials was high. Pooled analysis for three RCTs showed that NMBAs significantly reduced 28-day mortality [ OR 0. 58, 95% CI( 0. 39, 0. 86) , P = 0. 007] and increased ventilator-free days within 28 days [ WMD 1. 91 d, 95% CI( 0. 28,3. 55) , P =0. 02] in ARDS compared with the control group. Conclusion The present meta-analysis indicates that NMBAs reduce the 28-day mortality and increase ventilator-free days within 28 days in ARDS.