癌癥相關性乏力預測非小細胞肺癌患者手術預后的臨床研究_《華西醫學》

作者：

李娟 ¹ , 石銳 ² , 余萍 ¹ , 文彥 ¹ ,  何金濤 ¹

1四川省腫瘤醫院肺部腫瘤病區（成都，610041）;2四川大學華西醫院骨科;

關鍵詞：

非小細胞肺癌癌癥相關性乏力 TNM分期總生存期

DOI：

10.7507/1002-0179.20130443

視頻：

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目的　評估非小細胞肺癌患者中癌癥相關性乏力的發生情況及其與患者臨床病理特征和生存期之間的相互關系。方法　應用簡明疲勞量表中文版評估2008年12月－2009年12月間收治的72例初治肺癌患者，入組患者均完成根治性手術及術后生存隨訪。結果　72例早期非小細胞肺癌患者中，無乏力9例（12.5%），輕度乏力48例（66.7%），中度乏力15例（20.8%），重度乏力0例（0%），乏力總體發生率為87.5%。乏力指數與患者的年齡、性別、吸煙史均無相關性，與患者的體力狀況評分（ECOG PS）、TNM分期呈正相關，與中位生存期呈負相關，均有統計學意義（P＜0.05）。結論　癌癥相關性乏力作為非小細胞肺癌患者中普遍存在的一種癥狀，不僅能夠反映患者當時的主觀感受和生活狀況，還可能是判斷患者術后病理分期及最終總生存期的預測因素。

引用本文： 李娟,石銳,余萍,文彥,何金濤. 癌癥相關性乏力預測非小細胞肺癌患者手術預后的臨床研究. 華西醫學, 2013, 28(9): 1411-1414. doi: 10.7507/1002-0179.20130443 復制

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14.	Cheville AL, Novotny PJ, Sloan JA, et al. Fatigue, dyspnea, and cough comprise a persistent symptom cluster up to five years after diagnosis with lung cancer[J]. J Pain Symptom Manage, 2011, 42(2): 202-212.
15.	Lin S, Chen Y, Yang L, et al. Pain, fatigue, disturbed sleep and distress comprised a symptom cluster that related to quality of Life and functional status of lung cancer surgery patients[J]. J Clin Nurs, 2013, 22(9-10): 1281-1290.
16.	王季穎, 魯冰. 晚期非小細胞肺癌患者癌癥相關性乏力的臨床觀察[J]. 腫瘤, 2011, 31(12): 1108-1110.
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1. 　Cramp F, Byron-Daniel J. Exercise for the management of cancer-related fatigue in adults[J]. Cochrane Database Syst Rev, 2012, 11(11): CD006145.
2. 　Campos MP, Hassan BJ, Riechelmann R, et al. Cancer-related fatigue: a practical review[J]. Ann Oncol, 2011, 22(6): 1273-1279.
3. 　Bunn PA. Worldwide overview of the current status of lung cancer diagnosis and treatment[J]. Arch Pathol Lab Med, 2012, 136(12): 1478-1481.
4. 　Wang XS, Hao XS, Wang Y, et al. Validation study of the Chinese version of the Brief Fatigue Inventory (BFI-C)[J]. J Pain Symptom Manage, 2004, 27(4): 322-332.
5. 　Mock V, Atkinson A, Barsevick A, et al. NCCN practice guidelines for cancer-related fatigue[J]. Oncology (Williston Park), 2000, 14(11A): 151-161.
6. 　Detterbeck FC, Boffa DJ, Tanoue LT. The new lung Cancer staging system[J]. Chest, 2009, 136(1): 260-271.
7. 　Hoffman AJ, Brintnall RA, Brown JK. Too sick not to exercise:using a 6-week, home-based exercise intervention for cancer-related fatigue self-management for postsurgical non-small cell lung cancer patients[J]. Cancer Nurs, 2013, 36(3): 175-188.
8. 　Hung R, Krebs P, Coups EJ, et al. Fatigue and functional impairment in early-stage non-small cell lung cancer survivors[J]. J Pain Symptom Manage, 2011, 41(2): 426-435.
9. 　沈嬋娟, 曹培國. 肺癌患者癌因性疲乏的影響因素及其與生活質量關系的研究[J]. 中國腫瘤臨床與康復, 2010, 17( 01): 87-90.
10. 　Blackhall L, Petroni G, Shu J, et al. A pilot study evaluating the safety and efficacy of modafinal for cancer-related fatigue[J]. J Palliat Med, 2009, 12(5): 433-439.
11. 　Yang P, Cheville AL, Wampfler JA, et al. Quality of Life and symptom burden among long-term lung cancer survivors[J]. J Thorac Oncol, 2012, 7(1): 64-70.
12. 　Dhillon HM, van der Ploeg HP, Bell ML, et al. The impact of physical activity on fatigue and quality of life in lung cancer patients: a randomised controlled trial protocol[J]. BMC Cancer, 2012, 12(12): 572.
13. 　Molassiotis A, Lowe M, Blackhall F, et al. A qualitative exploration of a respiratory distress symptom cluster in lung cancer: cough, breathlessness and fatigue[J]. Lung Cancer, 2011, 71(1): 94-102.
14. 　Cheville AL, Novotny PJ, Sloan JA, et al. Fatigue, dyspnea, and cough comprise a persistent symptom cluster up to five years after diagnosis with lung cancer[J]. J Pain Symptom Manage, 2011, 42(2): 202-212.
15. 　Lin S, Chen Y, Yang L, et al. Pain, fatigue, disturbed sleep and distress comprised a symptom cluster that related to quality of Life and functional status of lung cancer surgery patients[J]. J Clin Nurs, 2013, 22(9-10): 1281-1290.
16. 　王季穎, 魯冰. 晚期非小細胞肺癌患者癌癥相關性乏力的臨床觀察[J]. 腫瘤, 2011, 31(12): 1108-1110.
17. 　Paddison JS, Temel JS, Fricchione GL, et al. Using the differential from complete blood counts as a biomarker of fatigue in advanced non-small-cell lung cancer: an exploratory analysis[J]. Palliat Support Care, 2009, 7(2): 213-217.
18. 　Cheville AL, Novotny PJ, Sloan JA, et al. The value of a symptom cluster of fatigue, dyspnea, and cough in predicting clinical outcomes in lung cancer survivors[J]. J Pain Symptom Manage, 2011, 42(2): 213-221.

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癌癥相關性乏力預測非小細胞肺癌患者手術預后的臨床研究

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《華西醫學》

癌癥相關性乏力預測非小細胞肺癌患者手術預后的臨床研究

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