血管內皮生長因子、白細胞分化抗原34及CXC趨化因子受體4在轉移性鼻咽癌患者鼻咽部腫瘤組織的表達與預后分析_《華西醫學》

作者：

羅馨玫 ,  姜愚 , 鄒立群 , 冀曉輝 , 鄧國華 , 湯捷

四川大學華西醫院腫瘤中心/生物治療國家重點實驗室（成都，610041）;

關鍵詞：

轉移性鼻咽癌血管內皮生長因子抗原，CD34 受體，CXCR4 預后

DOI：

10.7507/1002-0179.20130442

視頻：

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目的　檢測血管內皮生長因子（VEGF）、白細胞分化抗原34（CD34）及CXC趨化因子受體4（CXCR4）在轉移性鼻咽癌患者鼻咽部腫瘤組織中的表達，探討它們與鼻咽癌各種臨床病理因素的關系以及它們之間的相互聯系。方法　采用免疫組織化學鏈霉素抗生物素蛋白-過氧化物酶連結法檢測2003年3月－2009年5月35例轉移性鼻咽癌患者VEGF、CD34及CXCR4在鼻咽部腫瘤組織中的表達情況，結合患者臨床病理特征進行分析。結果　轉移性鼻咽癌患者鼻咽部腫瘤組織中的VEGF及CXCR4陽性表達率分別為62.9%（22∕35）和42.9%（15∕35），CD34計數為11～92，平均43.2 ± 20.5。無肺轉移較有肺轉移的患者VEGF的陽性表達率高（78.9%、43.8%，P=0.043），多器官轉移較單器官轉移的患者CXCR4的表達強度高（62.5%、26.3%，P=0.044）。結論　VEGF表達陽性的患者易發生肺轉移；CXCR4強表達的患者易發生多器官轉移。

引用本文： 羅馨玫,姜愚,鄒立群,冀曉輝,鄧國華,湯捷. 血管內皮生長因子、白細胞分化抗原34及CXC趨化因子受體4在轉移性鼻咽癌患者鼻咽部腫瘤組織的表達與預后分析. 華西醫學, 2013, 28(9): 1405-1410. doi: 10.7507/1002-0179.20130442 復制

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2.	Hui EP, Leung SF, Au JS, et al. Lung metastasis alone in nasopharyngeal carcinoma: a relatively favorable prognostic group. A study by the Hong Kong Nasopharyngeal Carcinoma Study Group[J]. Cancer, 2004, 101(2): 300-306.
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13.	Mattern J, Koomägi R, Volm M. Biological characterization of subgroups of squamous cell lung carcinomas[J]. Clin Cancer Res, 1999, 5(6): 1459-1463.
14.	Weidner N. Current pathologic methods for measuring intratumoral microvessel density within breast carcinoma and other solid tumors[J]. Breast Cancer Res Treat, 1995, 36(2): 169-180.
15.	Pan J, Kong L, Lin S, et al. The clinical significance of coexpression of cyclooxygenases-2, vascular endothelial growth factors, and epidermal growth factor receptor in nasopharyngeal carcinoma[J]. Laryngoscope, 2008, 118(11): 1970-1975.
16.	Segawa Y, Oda Y, Yamamoto H, et al. Close correlation between CXCR4 and VEGF expression and their prognostic implications in nasopharyngeal carcinoma[J]. Oncol Rep, 2009, 21(5): 1197-1202.
17.	Chan CM, Ma BB, Hui EP, et al. Cyclooxygenase-2 expression in advanced nasopharyngeal carcinoma--a prognostic evaluation and correlation with hypoxia inducible factor 1alpha and vascular endothelial growth factor[J]. Oral Oncol, 2007, 43(4): 373-378.
18.	Hui EP, Chan AT, Pezzella F, et al. Coexpression of hypoxia-inducible factors 1alpha and 2alpha, carbonic anhydraseⅨ, and vascular endothelial growth factor in nasopharyngeal carcinoma and relationship to survival[J]. Clin Cancer Res, 2002, 8(8): 2595-2604.
19.	Kim TJ, Lee YS, Kang JH, et al. Prognostic significance of expression of VEGF and Cox-2 in nasopharyngeal carcinoma and its association with expression of C-erbB2 and EGFR[J]. J Surg Oncol, 2011, 103(1): 46-52.
20.	Folkman J. What is the evidence that tumors are angiogenesis dependent[J]. J Natl Cancer Inst, 1990, 82(1): 4-6.
21.	曾俊, 龔玲玲, 陳曉, 等. 微血管密度和血管內皮生長因子、P53表達與鼻咽癌預后的關系[J]. 湖北醫科大學學報, 2000, 21(3): 187-189.
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23.	Rubio L, Burgos JS, Morera C, et al. Morphometric study of tumor angiogenesis as a new prognostic factor in nasopharyngeal carcinoma patients[J]. Pathol Oncol Res, 2000, 6(3): 210-216.
24.	Wang N, Wu QL, Fang Y, et al. Expression of chemokine receptor CXCR4 in nasopharyngeal carcinoma: pattern of expression and correlation with clinical outcome[J]. J Transl Med, 2005(3): 26.
25.	Murakami T, Maki W, Cardones AR, et al. Expression of CXC chemokine receptor-4 enhances the pulmonary metastatic potential of murine B16 melanoma cells[J]. Cancer Res, 2002, 62(24): 7328-7334.
26.	Kang Y, Siegel PM, Shu W, et al. A multigenic program mediating breast cancer metastasis to bone[J]. Cancer Cell, 2003, 3(6): 537-549.

1. 　Lo KW, To KF, Huang DP. Focus on nasopharyngeal carcinoma[J]. Cancer Cell, 2004, 5(5): 423-428.
2. 　Hui EP, Leung SF, Au JS, et al. Lung metastasis alone in nasopharyngeal carcinoma: a relatively favorable prognostic group. A study by the Hong Kong Nasopharyngeal Carcinoma Study Group[J]. Cancer, 2004, 101(2): 300-306.
3. 　Al-Sarraf M, LeBlanc M, Giri PG, et al. Chemoradiotherapy versus radiotherapy in patients with advanced nasopharyngeal cancer: phase Ⅲ randomized Intergroup study 0099[J]. J Clin Oncol, 1998, 16(4): 1310-1317.
4. 　Pfrister DG, Aug K, Brizel DM, et al. NCCN clinical practice guidelines in oncology: head and neck cancers[J]. JNCCN, 2011, 11(9): 596-650.
5. 　Wakisaka N, Wen QH, Yoshizaki T, et al. Association of vascular endothelial growth factor expression with angiogenesis and lymph node metastasis in nasopharyngeal carcinoma[J]. Laryngoscope, 1999, 109(5): 810-814.
6. 　Kong HL, Crystal RG. Gene therapy strategies for tumor antiangiogenesis[J]. J Natl Cancer Inst, 1998, 90(4): 273-286.
7. 　Hanahan D, Folkman J. Patterns and emerging mechanisms of the angiogenic Switch during tumorigenesis[J]. Cell, 1996, 86(3): 353-364.
8. 　Ben-Baruch A. Organ selectivity in metastasis: regulation by chemokines and their receptors[J]. Clin Exp Metastasis, 2008, 25(4): 345-356.
9. 　Kato M, Kitayama J, Kazama S, et al. Expression pattern of CXC chemokine receptor-4 is correlated with lymph node metastasis in human invasive ductal carcinoma[J]. Breast Cancer Res, 2003, 5(5): R144-R150.
10. 　Liang Z, Yoon Y, Votaw J, et al. Silencing of CXCR4 blocks breast cancer metastasis[J]. Cancer Res, 2005, 65(3): 967-971.
11. 　蘇麗萍, 張進平, 陳晉, 等. CXCR4在肺癌組織中的表達及臨床意義[J]. 中國癌癥雜志, 2005, 15(2): 97-100.
12. 　Brand S, Dambacher J, Beigel F, et al. CXCR4 and CXCL12 are inversely expressed in colorectal cancer cells and modulate cancer cell migration, invasion and MMP-9 activation[J]. Exp Cell Res, 2005, 310(1): 117-130.
13. 　Mattern J, Koomägi R, Volm M. Biological characterization of subgroups of squamous cell lung carcinomas[J]. Clin Cancer Res, 1999, 5(6): 1459-1463.
14. 　Weidner N. Current pathologic methods for measuring intratumoral microvessel density within breast carcinoma and other solid tumors[J]. Breast Cancer Res Treat, 1995, 36(2): 169-180.
15. 　Pan J, Kong L, Lin S, et al. The clinical significance of coexpression of cyclooxygenases-2, vascular endothelial growth factors, and epidermal growth factor receptor in nasopharyngeal carcinoma[J]. Laryngoscope, 2008, 118(11): 1970-1975.
16. 　Segawa Y, Oda Y, Yamamoto H, et al. Close correlation between CXCR4 and VEGF expression and their prognostic implications in nasopharyngeal carcinoma[J]. Oncol Rep, 2009, 21(5): 1197-1202.
17. 　Chan CM, Ma BB, Hui EP, et al. Cyclooxygenase-2 expression in advanced nasopharyngeal carcinoma--a prognostic evaluation and correlation with hypoxia inducible factor 1alpha and vascular endothelial growth factor[J]. Oral Oncol, 2007, 43(4): 373-378.
18. 　Hui EP, Chan AT, Pezzella F, et al. Coexpression of hypoxia-inducible factors 1alpha and 2alpha, carbonic anhydraseⅨ, and vascular endothelial growth factor in nasopharyngeal carcinoma and relationship to survival[J]. Clin Cancer Res, 2002, 8(8): 2595-2604.
19. 　Kim TJ, Lee YS, Kang JH, et al. Prognostic significance of expression of VEGF and Cox-2 in nasopharyngeal carcinoma and its association with expression of C-erbB2 and EGFR[J]. J Surg Oncol, 2011, 103(1): 46-52.
20. 　Folkman J. What is the evidence that tumors are angiogenesis dependent[J]. J Natl Cancer Inst, 1990, 82(1): 4-6.
21. 　曾俊, 龔玲玲, 陳曉, 等. 微血管密度和血管內皮生長因子、P53表達與鼻咽癌預后的關系[J]. 湖北醫科大學學報, 2000, 21(3): 187-189.
22. 　Ogawa Y, Chung YS, Nakata B, et al. Microvessel quantitation in invasive breast cancer by staining for factorⅧ-related antigen[J]. Br J Cancer, 1995, 71(6): 1297-1301.
23. 　Rubio L, Burgos JS, Morera C, et al. Morphometric study of tumor angiogenesis as a new prognostic factor in nasopharyngeal carcinoma patients[J]. Pathol Oncol Res, 2000, 6(3): 210-216.
24. 　Wang N, Wu QL, Fang Y, et al. Expression of chemokine receptor CXCR4 in nasopharyngeal carcinoma: pattern of expression and correlation with clinical outcome[J]. J Transl Med, 2005(3): 26.
25. 　Murakami T, Maki W, Cardones AR, et al. Expression of CXC chemokine receptor-4 enhances the pulmonary metastatic potential of murine B16 melanoma cells[J]. Cancer Res, 2002, 62(24): 7328-7334.
26. 　Kang Y, Siegel PM, Shu W, et al. A multigenic program mediating breast cancer metastasis to bone[J]. Cancer Cell, 2003, 3(6): 537-549.

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血管內皮生長因子、白細胞分化抗原34及CXC趨化因子受體4在轉移性鼻咽癌患者鼻咽部腫瘤組織的表達與預后分析

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血管內皮生長因子、白細胞分化抗原34及CXC趨化因子受體4在轉移性鼻咽癌患者鼻咽部腫瘤組織的表達與預后分析

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