ObjectivesTo evaluate the economic efficacy of nab-paclitaxel (NAB-P) combined with gemcitabine (GEM) versus GEM alone in the treatment of metastatic pancreatic cancer in China.MethodsA Markov model simulating the costs and health outcomes was developed to estimate quality-adjusted life years (QALYs) and incremental cost-effectiveness ratio (ICER). The impact of parameter uncertainty on the model was assessed by deterministic one-way sensitivity analysis.ResultsNAB-P combined with GEM was shown superior efficacy compared to gemcitabine monotherapy, however with higher costs. The ICER between the two groups was 964 780.79￥/QALY.ConclusionsCompared with gemcitabine monotherapy, NAB-P combined with GEM is not cost-effective. The conclusion is confirmed by deterministic one-way sensitivity analysis.
Post-stroke cognitive impairment (PSCI) is a common complication of stroke that severely affects patients' quality of life and social functional recovery. Quantitative electroencephalography (QEEG), as a non-invasive neuroelectrophysiological technique with high temporal resolution, can reveal PSCI-related brain dysfunction and plasticity changes from multiple levels and dimensions, including neural oscillations, brain network connectivity, and dynamic optimization of brain function. However, its feature integration and efficacy evaluation system still require further refinement. In recent years, acupuncture has attracted increasing attention in the intervention of PSCI owing to its holistic regulatory effects and favorable safety profile. This review systematically integrates the characteristics of brain rhythms, brain functional networks, and dynamic brain activity in patients with PSCI, analyzes the associations between different electroencephalography (EEG) indicators and cognitive domains, and summarizes the multidimensional changes in EEG features following acupuncture intervention in PSCI. The aim is to provide evidence for a deeper understanding of the neuroelectrophysiological mechanisms underlying PSCI, while also offering references for the objective evaluation and modernization of acupuncture interventions.