ObjectiveTo review the regulatory effect of microRNA (miRNA) in wound heal ing, which abnormal expression associates with diabetes. MethodsThe literature on miRNA associating with wound heal ing was reviewed and summarized. ResultsmiRNA plays a key role in wound heal ing, including regulating inflammation, angiogenesis, granulation tissue formation, and re-epithel ization. ConclusionAbnormal expression of miRNA may be related to delayed healing of the diabetic wound, but further research is needed to confirm it.