Transcatheter aortic valve replacement (TAVR) is a reasonable alternative for patients with severe aortic stenosis who are at a medium or high risk from surgery, and it’s gradually extended to low-risk groups. The safety of surgery is confirmed with the advancement of technology and the improvement of surgical instruments, but surgical complications are still common. Cardiovascular collapse is the leading cause of death during the surgery and not rare. This article reported a case of cardiovascular collapse during TAVR who were successfully rescued, while literature review on the causes and treatment of cardiovascular collapse were made.