Objective To review researches of the role of inhibitorof differentiation 2(Id2) in skeletal muscle regeneration. Methods The latest original literature concerning Id2 and its role in skeletal muscle regeneration was extensively reviewed. Results Id2 could form heterodimers by combining with E protein to prevent myogenic regulatory factors (MRFs) forming heterodimers by combining with E protein, to inhibit the transcription activity of MRFs anddifferentiation of skeletal muscle cell. Conclusion Id2 plays an important role in skeletal muscle regeneration.
Objective To investigate the relationship between the level of serum-insulin like growth factor-1( IGF-1) and the nut ritional status of cancerous cachexia. Methods Colon cancer CT-26 cells were implanted subcutaneously to 30 liver2specified IGF-1 gene deleted (L ID) C57BL/ 6 mice to establish cancerous cachexia model and theother 30 C57BL/ 6 mice were included as cont rol group. The serum levels of IGF-1 , cytokine TNF-αand IL-6 , bloodglucose , albumin and t riglyceride were detected respectively on day 14 , 18 and 22 af ter the plantation of tumor. Thebody weight of mice , tumor weight and the weight af ter tumor removed in two group s were measured respectively.Results Af ter the plantation , the levels of IGF-1 in L ID group at different times were all significantly lower thanthose in cont rol group ( Plt; 0. 05) . The serum levels of TNF-α, IL-6 , blood glucose and t riglyceride were ascendinggradually over time ( Plt; 0. 05) , but weight s af ter tumor removed and the level of albumin were descending in twogroup s ( Plt; 0. 05) . Compared with the cont rol group , the serum levels of IL-6 , TNF-α, blood glucose and t riglyceride in L ID tumor-bearing mice were all significantly higher at different time point s ( P lt; 0. 05) . On day 18 and 22 ,the weight s af ter tumor removed and the amount of ingestion in L ID group were significantly lower than those in thecont rol group ( Plt; 0. 05) . Conclusion Compared with the low level of IGF-1 in cancerous cachexia , normal level ofserum IGF-1 may represent lower degree of cancerous cachexia2related cytokines and better nut ritional state , whichmay provide a novel idea of the therapy of cancerous cachexia.
In 2014, the new concept of embolic stroke of undetermined source (ESUS) was first proposed by cryptogenic stroke/ESUS International Working Group. In the past 5 years, related clinical researches of ESUS have been deepened, and the results of many large clinical studies have been published. However, the guiding significance of this new concept to clinical practice is still controversial. By reviewing the background, diagnostic criteria, assessment, common emboli sources, anticoagulant therapy research advances and related limitations of ESUS, and analyzing the possible causes of negative anticoagulant therapy results, we explored the clinical value of this new classification.
Objective To evaluate the quality of clinical studies on dentistry from the Chinese Journals. Methods Clinical studies in Chinese Journal of Conservative Dentistry of 2002 were searched. The quality of the clinical studies on assessment of treatments’ efficacy was evaluated. Results Among 204 related studies from 12 issues, there were 93 (45.58%) restrospective intervention studies, 6 randomized controlled blinded trials (2.94%), 42 randomized trials without blindness (20.58%), 20 controlled trials without randomization (9.80%) and 25 clinical observational studies (12.25%). The statistical analysis showed that 20 studies were with inappropriate methods. Conclusions It is necessary to improve the design and statistical analysis of clinical studies on stomatology in China to produce high-quality research evidence.
【Abstract】 Objective To review the recent progress of cell therapy in cl inical appl ications. Methods Therecent l iterature about cell therapy in cl inical appl ications was extensively reviewed. Results Based on the advances in cell biology, especially the rapid progress in stem cell biology, an increasing number of cl inical trials about cell therapy for management of various diseases, such as cardiovascular system diseases, neural system diseases, musculo-skeletal diseases, diabetes, stress urinary incontinence, and others, had been reported with encouraging results. All these showed that cell therapy had great potentials in cl inical appl ication. Conclusion Cell therapy provides a novel approach for the treatment of many human diseases. However, the mechanism remains to be fully elucidated.
ObjectiveTo summarize the research status, hotspots, and development trends of ocular toxocariasis (OT) from 1993 to 2024. MethodsThe literature related to OT included in the Web of Science Core Collection dataset from 1993 to 2024 was retrieved and screened. The bibliometric softwares, VOSviewer and CiteSpace were applied to visually analyze the annual publication volume, countries, institutions, core authors, journal distribution, co-cited references, and keyword clustering. ResultsA total of 279 articles were included. There was an overall fluctuating upward trend of annual publications from 1993 to 2024, with the highest number of publications in 2020 (24 articles, accounting for 8.60%). There was an increasing trend in the frequency of citations to relevant literature. Authors from the United States had the highest number of publications (50 articles, 17.92%). Among institutions, Tokyo Medical and Dental University had the most published articles (11 articles, 3.94%). Among authors, professor Ding Xiaoyan from Zhongshan Eye Center at Sun Yat-sen University is the author with the most published papers (6 articles, 2.15%). Among journals, Ocul Immunol Inflamm had the highest number of published articles (21 articles, 7.53%). Highly cited references showed a significant clustering tendency, which were epidemiology, clinical characteristics and treatment, and immunological diagnosis. Keyword co-occurrence analysis showed that clinical features, serological diagnosis, epidemiology, immunodiagnosis, granuloma and treatment were high-frequency keywords. Timeline view map showed that the 9 clusters could be divided into 3 categories: epidemiological investigation including risk factors and seroprevalence (#0), clinical research including clinical features and treatment modalities (#1, #2, #3, # 6, #7), immunological detection and laboratory examination (#3, #5, #8). The keywords bursts analysis showed that the trend of research hot topics of OT had shifted from the initial study of animal experiments and immunological detection to the subsequent study of risk factor, and then to clinical characteristics studies combined with multimodal imaging technology. ConclusionsOver the past three decades, the number of publications on OT research has shown an increasing trend and the research hotspots have mainly focused on epidemiology, immunological detection and clinical features. The multimodal imaging diagnosis technology based on clinical features and the treatment strategy based on pathogenesis remain crucial directions for future research.
ObjectiveTo review the present situation of experimental study and clinical application of middle and lower cervical anterior transpedicular screw (CATPS) fixation. MethodsThe literature on the CATPS fixation was reviewed and summarized. ResultsThere is a safe area to implement the CATPS fixation and anterior decompression, and fusion can be done at the same time. It can provide a new idea for surgical treatment of complex cervical disease. Although it has so many advantages, its complex operating methods and optimal design of plate should be attended. Long-term effectiveness and specific indications still should be researched. ConclusionMiddle and lower cervical anterior transpedicular screw is an effective and safe fixation for cervical diseases. But the time for clinical use is short, the long-term effectiveness, surgical technique, and internal fixation devices are still need further study.
ObjectiveTo review the application status and research progress of alginate dressings. MethodsThe related home and abroad literature was reviewed, and the relevant product standards and regulations were summarized. ResultsAlginate dressings have been widely used in clinical because of the characteristics of anti-infection and promoting wound healing. It is mainly used on the wound surface and filled in the wound. Pure alginate dressing is limited in promoting wound healing. A large number of studies are devoted to promoting the activity with other polymer composite to get better dressing. In addition, the industry standards and regulation of alginate dressing products are also gradually improved and standardized. ConclusionAlginate dressing, as an advanced bio-dressing, whose effectiveness has been confirmed, its derivative dressings are also continuously expanding.
Objective To review the progress in the treatment and research of massive rotator cuff tears. Methods Recent l iteratures about the treatment and research of massive rotator cuff tears were reviewed. Results Treatment options of massive rotator cuff tears include nonoperative treatment, debridement, direct repair, tendon transfer, and repair with various substitutes, but the outcome is unpredictable. Recently, many experimental studies on the treatment of massive rotator cuff tears, such as gene therapy, cell therapy, and tissue engineering techniques, can provide cl inicians with new treatment strategies. Conclusion The treatment of massive rotator cuff tears pose a distinct cl inical challenge for the orthopaedist, depending on the overall presentation. The effect of traditional operation method to repair massive rotator cuff tears is limited. The treatment and research of massive rotator cuff tears still need to be studied.
To introduce the lasted advance of research on cytokine in the process of union-fracture as well as cl inical appl ication. Methods The related biomedical research materials at home and broad were consulted and analyzed.Results Cytokines participate in and promote the process of union of fracture. Conclusion Nowadays, there are more detailed study at the level of cells. But the mechanism of interaction between cells has still not completely been known in the process of union-fracture. Therefore, further elucidating function and mechanism, especially interaction between cytokines is what we are gong to solve in the future.