Coronavirus disease 2019 that started in Wuhan, Hubei Province in December 2019, has spread rapidly across China. Radiography provides an important basis for clinical diagnosis of coronavirus disease 2019 and plays a crucial role in fighting against the epidemic. In the face of public health emergencies, how to quickly set up a team for accurate prevention and control in the first time and how to carry out radiological examination and diagnosis ina scientific, orderly, safe and efficient manner are the key measures to support the hospital in effectively responding to the epidemic. This paper summarized the innovative management experience of the radiology department of West China Hospital of Sichuan University in the prevention and control of nosocomial infection and discipline construction in the fight against the outbreak of coronavirus disease 2019.