Orlistat, which has a new mechanism of action, is currently the only approved weight-loss drug in China. In addition to controlling body weight, orlistat can significantly improve blood glucose, blood pressure, dyslipidemia, adiponectin, insulin concentration and other obesity-related biochemical indicators in patients with overweight/obese. Recently, orlistat was approved for weight management in patients with polycystic ovary syndrome. Although there are clinical trials supporting the good weight loss efficacy of orlistat, its long-term safety and effectiveness in obesity-related diseases still need to be further determined. This article provides a brief review of the new progress in the clinical efficacy and safety of orlistat, aiming to provide a reference for the more rational drug application.
Objective To investigate the improvement of professional and research abilities of medical imaging technology trainees after completing their training, and to provide reference for a clinical and research-oriented training model. Methods Medical imaging technology trainees who pursuedfurther training in the Department of Radiology at West China Hospital of Sichuan University between March 2020 and February 2024 were enrolled. Data were collected through targeted questionnaires, covering personal information, training process, and post-training outcomes upon returning to their home institutions. Results A total of 150 questionnaires were distributed, and 128 were returned. The survey results showed that trainees who successfully implemented new technologies were more likely to have held administrative positions prior to training compared to those who did not (34.7% vs. 15.1%; P=0.023). Trainees who trained for 6 months were more likely to participate in publications compared to those who trained for 3 months [odds ratio=4.77, 95% confidence interval (1.27, 17.96), P=0.021]. Conclusion The clinical and research training system enables imaging technologists to better implement new technologies and improve research abilities upon returning to their home institutions.