Objective To explore the application effects of nursing quality control mode based on nurse satisfaction. Methods A total of 226 nurses in 12 nursing units were selected from December 2013 to June in 2014 as the study subjects. Then, we compared the nurse satisfaction, patient satisfaction, and the effect of nursing quality control before and after the implementation of quality control mode in which nurses participated actively. Results After a half-year practice of nursing quality mode, all the investigation items of the project were significantly different from those before the mode application (P>0.05), except Q1, Q2, Q8, and Q10 in the nurse satisfaction questionnaire, q1, q2, q3, q4, and q14 in the patient satisfaction questionnaire, and quality of emergency management in the nursing quality control section. Conclusion Application of nursing quality control mode can fully mobilize the enthusiasm of nurses, improve nurse satisfaction and the effect of nursing quality management, which has a high value of application in clinical nursing management.