ObjectiveTo explore the consistency between core needle biopsy (CNB) by color ultrasound location and surgical biopsy in the diagnosis of breast diseases. MethodsBetween March 2012 and March 2015, the results of ultrasound-guided CNB pathological examination of 218 cases of breast diseases were retrospectively analyzed, which were compared with the results of postoperative histopathological diagnosis to evaluate the ultrasound-guided CNB diagnosis. ResultsIn the 218 cases, 156 of mammary cancer were confirmed by CNB histopathological diagnosis, and 160 were confirmed by the postoperative pathological histological diagnosis; the false negative diagnosis by CNB pathological diagnosis was 4. The two methods were highly matched with each other (k=0.958,P<0.001). The sensitivity of CNB histopathological diagnosis for mammary cancer was 97.5%, while the specificity was 100.0% and the accuracy rate was 98.2%. ConclusionCNB histopathologic diagnosis of breast lesions had high accuracy and high consistency with postoperative histopathological diagnosis results, which is a reliable biopsy method for breast lesions.