This paper reviews the implementation of disease prevention and control policy of Sichuan province in three historic stages, and analyses the situation, challenges and tasks about disease prevention and controlling in future, based on the new requirements about hygiene and medicine. Three strategies should be taken: 1) to improve the capacity and quality of health service; 2) to optimize the structure of institutions and talent teams; 3) to focus on the Healthy Sichuan construction, the treatment-prevention synergy, and the poverty health care.