Elevated D-dimer is a common laboratory abnormality in clinical practice. Accurate interpretation and standardized management of its results are of great clinical value for the early identification, differential diagnosis and prognostic evaluation of related diseases. At present, there is still a lack of systematic consensus on the full-process diagnosis, treatment and management of elevated D-dimer in China. In clinical practice, problems such as inconsistent standards for result interpretation, coexistence of over-examination and missed diagnosis risks, and non-standard primary care diagnostic and treatment pathways are prevalent. This consensus aims to improve the standardization of diagnosis and treatment of diseases related to elevated D-dimer. It systematically elaborates on its epidemiological characteristics, laboratory testing specifications, etiology and pathogenesis, standardizes the full-process diagnostic and treatment pathways, and constructs a full-cycle closed-loop management system supported by multidisciplinary collaboration and centered on community-hospital linkage. This consensus is intended to provide clinicians with standardized, evidence-based practical guidance, standardize the clinical diagnosis and treatment practices for elevated D-dimer, reduce over-medicalization, missed diagnosis and misdiagnosis, promote precision and rational medical care, and improve patients' clinical outcomes.