ObjectiveTo investigate the methods and significance of early orthodontic treatment for class Ⅱ malocclusion with molars scissors bite. MethodsTen patients with classⅡ malocclusion with molars scissors bite from 2011 and 2014 were selected. Study models and clinical data of them were retrospectively analyzed. Cephalometric radiographs taken before and after treatment were traced and measured. Student's t-test was used to analyze whether there was a significant difference before and after treatment. ResultsAfter treatment, the change of SNA, S-Go/N-Me, and soft tissue facial angle was not significant(P>0.05). SNB, N-ANS, ANS-Me, and S-Go increased significantly. ANB, Y axis, H angle, lower lip to H-line, and inferior sulcus to H-line decreased significantly(P<0.05). The treatment duration was 12 months on average. ConclusionEarly treatment of molars scissors bite and class Ⅱmalocclusion can keep the mandible and tempromandibular joint function well through occlusion guidance and muscle balance, which may prevent the exacerbation of facial deformity effectively.