World Health Organization (WHO) published Core Competencies of Infection Prevention and Control Practitioners in 2020. This WHO document is a very useful guide for implementing the core competencies among infection prevention and control professionals (IPCPs). It is useful for standardisation of the competencies in the field of infection control through relevant formal training, practicum and assessment. This paper explains the framework of the WHO-list of core competencies in relation to the role and responsibilities of IPCPs. The value of introducing core competencies to IPCPs is really vital in the recognition of infection prevention and control as a medical specialty field. The IPCPs core competencies is also an essential guide for practitioners to advance in their professional and career development from novice to expert in the infection prevention and control field.