ObjectiveTo summarize and share the surgical nursing experiences for hybrid procedures in the treatment of congenital heart disease with diminished pulmonary blood flow and aortopulmonary collateral arteries (APCA). MethodWe retrospectively analyzed the clinical data, including nursing problems, interventions and outcomes, of 15 patients with congenital heart disease with diminished pulmonary blood flow and APCA treated between May 2011 and February 2012. ResultsAll operations were completed successfully with effective nursing interventions. No complications like low cardiac output syndrome, lung over-perfusion, vital organ dysfunction, neuropsychological disorder, or systemic infection were noticed. ConclusionsHybrid procedure in the treatment of congenital heart disease with diminished pulmonary blood flow and APCA with complex surgical procedures, intraoperative variables and high surgical risks requires multi-disciplinary collaboration. Effective surgical nursing intervention is important to ensure the successful completion of surgery, and reduce possible complications.