Objective To study the relationship between cell apoptosis and vascular disease.Methods The paper reviewed the concept, character, gene control and signal transduction of apoptosis associated with vascular disease.Results Cytokine, radiation could induce apoptosis of endothelial cells, and caused vascular damage.The apoptosis of smooth muscle cells was related to the atherosclerosis and restenosis of vessels.Conclusion Cells apoptosis is related to vascular disease significantly.