ObjectiveTo explore the status of the career maturity of medical students (eight-year program) and its related factors. MethodsFrom April to June in 2010, College Students Maturity Self-test Questionnaire was used for the investigation of the career maturity of the medical students (eight-year program) at West China Medical School of Sichuan University. ResultsThe subjects were graded into three groups according to the scores of their questionnaires:high, moderate, and low career maturity. The proportion of each group was 15.2%, 13.8%, 71.0%, respectively. Gender difference was not found in the overall career maturity (Z=-0.206, P=0.837), while there was positive correlation between grade and overall career maturity (rs=0.180, P=0.030). ConclusionThe medical students (eight-year program) with relatively low overall career maturity account for a larger proportion than those with high and median career maturity. As grade increases, career maturity changes significantly. This research suggests that long schooling medical students are in urgent need for prompt and valid professional career education.
目的 探討脂多糖（LPS）、白細胞介素-6（IL-6）和血小板活化因子（PAF）與重癥胸腹創傷后凝血功能紊亂發生的相關性及可能的致病機理。方法 收集2009年1月至2011年12月期間在中國人民解放軍第二五三醫院急診科就診、創傷指數≥17分且除外合并顱腦損傷及在急診科內死亡的胸腹創傷患者62例，在予以搶救、治療的同時抽血檢查血小板計數（PLT）、血漿D-二聚體（D-D）、部分活化凝血酶原時間（APTT）、凝血酶原時間（PT）、LPS、IL-6和PAF，并對其結果進行相關性分析。結果 本組患者就診時檢測的PLT為（157.73±78.11）×109/L， D-D為（1 023.88±208.72） U/L，APTT為（46.95±17.85） s，PT為（19.44±6.95） s，TT為（58.27±12.44）s，除PLT降低外，其余4項指標均升高或延長； LPS為（322.85±104.54） U/L，IL-6為（285.51±81.46） ng/mL，PAF為 （14 714.70±4 427.95） ng/L， 三者均升高； PLT與LPS、IL-6和PAF之間呈負相關關系（P＜0.001），而D-D、APTT、PT和TT與LPS、IL-6和PAF之間均呈正相關關系（P＜0.001）。結論 LPS、IL-6及PAF可能參與了重癥胸腹創傷后凝血功能障礙的發生；重癥胸腹損傷后出現的微循環障礙及內毒素血癥是凝血功能障礙發生的重要機理。針對LPS、IL-6和PAF進行早期干預，有可能改善重癥胸腹創傷患者的凝血功能障礙。