目的 總結纖維瘤病的治療經驗。方法 回顧性分析1998年6月至2007年6月峰峰集團孫莊礦醫院收治的39例纖維瘤病患者的臨床資料。結果 首次手術治療31例，其中治愈27例，復發4例； 保守治療的8例，與手術后復發的4例再次接受手術治療，其中10例治愈，2例復發（均為再手術病例）。結論 纖維瘤病若手術切除不徹底，易復發； 擴大切除術效果較好。
Objective To investigate the effect of repairing bone defect with tissue engineered bone seeded with the autologous red bone marrow (ARBM) and wrapped by the pedicled fascial flap and provide experimental foundation for cl inicalappl ication. Methods Thirty-two New Zealand white rabbits (male and/or female) aged 4-5 months old and weighing2.0-2.5 kg were used to make the experimental model of bilateral 2 cm defect of the long bone and the periosteum in the radius. The tissue engineered bone was prepared by seeding the ARBM obtained from the rabbits on the osteoinductive absorbing material containing BMP. The left side of the experimental model underwent the implantation of autologous tissue engineered bone serving as the control group (group A). While the right side was designed as the experimental group (group B), one 5 cm × 3 cm fascial flap pedicled on the nameless blood vessel along with its capillary network adjacent to the bone defect was prepared using microsurgical technology, and the autologous tissue engineered bone wrapped by the fascial flap was used to fill the bone defect. At 4, 8, 12, and 16 weeks after operation, X-ray exam, absorbance (A) value test, gross morphology and histology observation, morphology quantitative analysis of bone in the reparative area, vascular image analysis on the boundary area were conducted. Results X-ray films, gross morphology observation, and histology observation: group B was superior to group A in terms of the growth of blood vessel into the implant, the quantity and the speed of the bone trabecula and the cartilage tissue formation, the development of mature bone structure, the remolding of shaft structure, the reopen of marrow cavity, and the absorbance and degradation of the implant. A value: there was significant difference between two groups 8, 12, and 16 weeks after operation (P lt; 0.05), and there were significant differences among those three time points in groups A and B (P lt; 0.05). For the ratio of neonatal trabecula area to the total reparative area, there were significant differences between two groups 4, 8, 12, and 16 weeks after operation (P lt; 0.05), and there were significant differences among those four time points in group B (P lt; 0.05).For the vascular regenerative area in per unit area of the junctional zone, group B was superior to group A 4, 8, 12, and 16 weeks after operation (P lt; 0.05). Conclusion Tissue engineered bone, seeded with the ARBM and wrapped by the pedicled fascial flap, has a sound reparative effect on bone defect due to its dual role of constructing vascularization and inducing membrane guided tissue regeneration.
摘要:目的: 探討本次汶川大地震中擠壓綜合征的診斷和治療的有效方法。 方法 :對8例擠壓綜合征患者依據病史、癥狀、體征及實驗室檢查結果進行診斷,并主要針對急性腎衰和局部創傷給予綜合治療。 結果 :7例完全治愈,1例基本治愈,沒有死亡病例,優良率100%。 結論 :以補液、利尿和全身營養支持為主的綜合治療配合血液透析可很好地控制病情發展,促進轉歸;一旦明確診斷,應盡早實施局部骨筋膜室切開減壓或截肢術。Abstract: Objective: To study the treatment of crush syndrome after the Wenchuan earthquake. Methods : The crush syndrome was diagnosed in 8 cases based on the medical history, symptoms, physical examinations and laboratory findings. The amputation was performed on 2 patients. Partial bone compartment open decompression was done on 4 patients. And hemodialysis were used in two of them. Meanwhile the acute renal dysfunction and the local injuries were treated correspondingly. Results : Seven cases were completely recovered, 1 case was recovered partly. Conclusion : Fluid, diuretic and general nutritionbased treatment with hemodialysis if necessary can control disease progression and promote the patients recovery. Once crush syndrome was diagnosed, partial bone compartment open decompression or amputation should be implemented as soon as possible.