ObjectiveTo observe the therapeutic effect of the Tizanidine hydroehloride combined with non-steroidal anti-inflammatory drugs (NSAIDs) on fibromyalgia syndrome. MethodsA total of 166 patients collected from August 2011 to January 2013 were randomly divided into control group and treatment group (with 83 cases in each group), the NSAIDs was used for control group, and for the other group, the Tizanidine hydroehloride combined with NSAIDs was used. The patients in two groups were continuously treated for 2 weeks. And the first and second week after treatment, the psychological evaluation,visual analogue pain, activities of daily living were detected. During the treatment period, the average follow-up duration was 3 months. ResultsThe clinical efficacy was better after treatment in both of the two groups. The clinical efficacy was more significant in treatment group than that in the control group, and the occurrence of gastrointestinal discomfort were less in the treatment group than that in the control group. ConclusionTizanidine hydroehloride combined with NSAIDs is effective on fibromyalgia syndrome. And the Tizanidine hydroehloride can protect the gastrointestine from being injured.
目的：替扎尼定是具有解痙作用的α２腎上腺能受體激動劑，并具有一定的胃腸道保護作用，適用于單一治療或與非甾體消炎藥（NSAIDs）聯合治療急性痙攣性疼痛。通過替扎尼定和非甾體類抗炎藥物的聯合應用，臨床觀察和評估聯合用藥能否增強療效和增加安全性。方法：急性痙攣性疼痛70例，隨機分為兩組，一組服用替扎尼定2mg,bid+雙氯芬酸50 mg,bid，一組服用雙氯芬酸50 mg,bid+安慰劑2mg,bid。觀察藥物療效和不良反應。結果：聯用組的總有效率為70％，胃腸道不良反應發生率為12%,中樞神經系統不良反應發生率為18％；單用組的總有效率為56％，胃腸道不良反應發生率為32％，中樞神經系統不良反應發生率為10％。結論：替扎尼定和非甾體類藥物聯用具有更好的療效以及更高的藥物耐受性。