癲癇樣發作疾病的研究進展_Journal of Epilepsy

Authors：

龍娟 ,  任惠

昆明醫科大學第一附屬醫院老年神經內科（昆明 650032）;

Corresponding?author：

任惠, Email: rh-3338@163.com

Keywords：

暈厥; 睡眠障礙; 短暫性腦缺血發作; 面-臂肌張力障礙發作; 發作性運動障礙

DOI：

10.7507/2096-0247.20200007

Video：

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癲癇樣發作疾病的臨床癥狀與癲癇發作相似，臨床上易誤診為癲癇并給予不恰當的治療，誤診的后果非常嚴重。因此，早期正確診斷顯得尤為重要。臨床上常見的癲癇樣發作疾病包括：暈厥、震蕩性抽搐、心因性非癲癇發作、睡眠障礙、短暫性腦缺血發作、面-臂肌張力障礙發作、發作性運動障礙等。文章就癲癇樣發作疾病作一綜述，為相關疾病的臨床診療提供參考。

Citation： 龍娟, 任惠. 癲癇樣發作疾病的研究進展. Journal of Epilepsy, 2020, 6(1): 34-38. doi: 10.7507/2096-0247.20200007 Copy

1.	張潔. 暈厥與癲癇的鑒別診斷. 中國實用神經疾病雜志, 2016, 19(16): 104-105.
2.	Lempert T, Bauer M, Schmidt D. Syncope: a videometric analysis of 56 episodes of transient cerebral hypoxia. Ann Neurol, 1994, 36(2): 233-237.
3.	Brodtkorb E. Common imitators of epilepsy. Acta Neurol Scand Suppl, 2013, 196(8): 5-10.
4.	McCrory PR, Bladin PF, Berkovic SF. Retrospective study of concussive convulsions in elite Australian rules and rugby league footballers: phenomenology, aetiology, and outcome. BMJ, 1997, 314(7075): 171-174.
5.	廖圣芳, 陳漢民, 張銀清. 腦震蕩性暈厥誤診為外傷性癲癇54例分析. 中國誤診學雜志, 2003, 23(8): 1206-1207.
6.	Benbadis SR, Allen Hauser W. An estimate of the prevalence of psychogenic non-epileptic seizures. Seizure, 2000, 9(4): 280-281.
7.	Gedzelman ER, LaRoche SM. Long-term video EEG monitoring for diagnosis of psychogenic nonepileptic seizures. Neuropsychiatr Dis Treat, 2014, 10(5): 1979-1986.
8.	Reuber M, Elger CE. Psychogenic nonepileptic seizures: review and update. Epilepsy Behav, 2003, 4(3): 205-216.
9.	Mostacci B, Bisulli F, Alvisi L, et al. Ictal characteristics of psychogenic nonepileptic seizures: what we have learned from video/EEG recordings--a literature review. Epilepsy Behav, 2011, 22(2): 144-153.
10.	姜穎. 癲癇診斷及鑒別診斷的臨床思考. 中國醫藥指南, 2016, 14(11): 296-297.
11.	楊志仙. 夜間發作癲癇的診斷與鑒別. 世界睡眠醫學雜志, 2015, 2(6): 380-382.
12.	Schulz UG, Rothwell PM. Transient ischaemic attacks mimicking focal motor seizures. Postgrad Med J, 2002, 78(918): 246-247.
13.	Ali S, Khan MA, Khealani B. Limb-shaking transient ischemic attacks: case report and review of literature. BMC Neurol, 2006, 6(1): 5.
14.	Ma QF, Huang Q, Zhang Q, et al. Association between clinical features and prognosis of patients with limb-shaking transient ischemic attack. Chin Med J (Engl), 2013, 126(22): 4354-4357.
15.	Baquis GD, Pessin MS, Scott RM. Limb shaking?a carotid TIA. Stroke, 1985, 16(3): 444-448.
16.	Irani SR, Michell AW, Lang B, et al. Faciobrachial dystonic seizures precede Lgi1 antibody limbic encephalitis. Ann Neurol, 2011, 69(5): 892-900.
17.	張梅娟, 管得寧, 王曉云, 等. 面臂肌張力障礙型癲癇的臨床特征以及預后. 中國神經免疫學和神經病學雜志, 2018, 25(6): 443-446.
18.	Striano P. Faciobrachial dystonic attacks: seizures or movement disorder. Ann Neurol, 2011, 70(1): 179-180.
19.	Bhatia KP. The paroxysmal dyskinesias. J Neurol, 1999, 246(3): 149-155.
20.	黃嘯君, 曹立, 陳生弟. 發作性動作誘發性運動障礙臨床表現及遺傳學研究進展. 中國現代神經疾病雜志, 2013, 13(5): 457-462.
21.	Bruno MK, Hallett M, Gwinn-Hardy K, et al. Clinical evaluation of idiopathic paroxysmal kinesigenic dyskinesia: new diagnostic criteria. Neurology, 2004, 63(12): 2280-2287.
22.	Axel L. Cerebral blood flow determination by rapid-sequence computed tomography: theoretical analysis. Radiology, 1980, 137(3): 679-686.
23.	Kikuchi T, Nomura M, Tomita H, et al. Paroxysmal kinesigenic choreoathetosis (PKC): confirmation of linkage to 16p11-q21, but unsuccessful detection of mutations among 157 genes at the PKC-critical region in seven PKC families. J Hum Genet, 2007, 52(4): 334-341.
24.	Bruno MK, Lee HY, Auburger GW, et al. Genotype-phenotype correlation of paroxysmal nonkinesigenic dyskinesia. Neurology, 2007, 68(21): 1782-1789.
25.	Weber A, K?hler A, Hahn A, et al. Benign infantile convulsions (IC) and subsequent paroxysmal kinesigenic dyskinesia (PKD) in a patient with 16p11.2 microdeletion syndrome. Neurogenetics, 2013, 14(3-4): 251-253.
26.	Waln O, Jankovic J. Paroxysmal movement disorders. Neurol Clin, 2015, 33(1): 137-152.
27.	Tacik P, Loens S, Schrader C, et al. Severe familial paroxysmal exercise-induced dyskinesia. J Neurol, 2014, 261(10): 2009-2015.
28.	Nobili L, Proserpio P, Combi R, et al. Nocturnal frontal lobe epilepsy. Curr Neurol Neurosci Rep, 2014, 14(2): 424.
29.	Becchetti A, Aracri P, Meneghini S, et al. The role of nicotinic acetylcholine receptors in autosomal dominant nocturnal frontal lobe epilepsy. Front Physiol, 2015, 6(3): 22.
30.	Liu XR, Huang D, Wang J, et al. Paroxysmal hypnogenic dyskinesia is associated with mutations in the PRRT2 gene. Neurol Genet, 2016, 2(2): e66.
31.	Steinlein OK. Genetic heterogeneity in familial nocturnal frontal lobe epilepsy. Prog Brain Res, 2014, 213(6): 1-15.
32.	Picard F, Makrythanasis P, Navarro V, et al. DEPDC5 mutations in families presenting as autosomal dominant nocturnal frontal lobe epilepsy. Neurology, 2014, 82(23): 2101-2106.

1. 張潔. 暈厥與癲癇的鑒別診斷. 中國實用神經疾病雜志, 2016, 19(16): 104-105.
2. Lempert T, Bauer M, Schmidt D. Syncope: a videometric analysis of 56 episodes of transient cerebral hypoxia. Ann Neurol, 1994, 36(2): 233-237.
3. Brodtkorb E. Common imitators of epilepsy. Acta Neurol Scand Suppl, 2013, 196(8): 5-10.
4. McCrory PR, Bladin PF, Berkovic SF. Retrospective study of concussive convulsions in elite Australian rules and rugby league footballers: phenomenology, aetiology, and outcome. BMJ, 1997, 314(7075): 171-174.
5. 廖圣芳, 陳漢民, 張銀清. 腦震蕩性暈厥誤診為外傷性癲癇54例分析. 中國誤診學雜志, 2003, 23(8): 1206-1207.
6. Benbadis SR, Allen Hauser W. An estimate of the prevalence of psychogenic non-epileptic seizures. Seizure, 2000, 9(4): 280-281.
7. Gedzelman ER, LaRoche SM. Long-term video EEG monitoring for diagnosis of psychogenic nonepileptic seizures. Neuropsychiatr Dis Treat, 2014, 10(5): 1979-1986.
8. Reuber M, Elger CE. Psychogenic nonepileptic seizures: review and update. Epilepsy Behav, 2003, 4(3): 205-216.
9. Mostacci B, Bisulli F, Alvisi L, et al. Ictal characteristics of psychogenic nonepileptic seizures: what we have learned from video/EEG recordings--a literature review. Epilepsy Behav, 2011, 22(2): 144-153.
10. 姜穎. 癲癇診斷及鑒別診斷的臨床思考. 中國醫藥指南, 2016, 14(11): 296-297.
11. 楊志仙. 夜間發作癲癇的診斷與鑒別. 世界睡眠醫學雜志, 2015, 2(6): 380-382.
12. Schulz UG, Rothwell PM. Transient ischaemic attacks mimicking focal motor seizures. Postgrad Med J, 2002, 78(918): 246-247.
13. Ali S, Khan MA, Khealani B. Limb-shaking transient ischemic attacks: case report and review of literature. BMC Neurol, 2006, 6(1): 5.
14. Ma QF, Huang Q, Zhang Q, et al. Association between clinical features and prognosis of patients with limb-shaking transient ischemic attack. Chin Med J (Engl), 2013, 126(22): 4354-4357.
15. Baquis GD, Pessin MS, Scott RM. Limb shaking?a carotid TIA. Stroke, 1985, 16(3): 444-448.
16. Irani SR, Michell AW, Lang B, et al. Faciobrachial dystonic seizures precede Lgi1 antibody limbic encephalitis. Ann Neurol, 2011, 69(5): 892-900.
17. 張梅娟, 管得寧, 王曉云, 等. 面臂肌張力障礙型癲癇的臨床特征以及預后. 中國神經免疫學和神經病學雜志, 2018, 25(6): 443-446.
18. Striano P. Faciobrachial dystonic attacks: seizures or movement disorder. Ann Neurol, 2011, 70(1): 179-180.
19. Bhatia KP. The paroxysmal dyskinesias. J Neurol, 1999, 246(3): 149-155.
20. 黃嘯君, 曹立, 陳生弟. 發作性動作誘發性運動障礙臨床表現及遺傳學研究進展. 中國現代神經疾病雜志, 2013, 13(5): 457-462.
21. Bruno MK, Hallett M, Gwinn-Hardy K, et al. Clinical evaluation of idiopathic paroxysmal kinesigenic dyskinesia: new diagnostic criteria. Neurology, 2004, 63(12): 2280-2287.
22. Axel L. Cerebral blood flow determination by rapid-sequence computed tomography: theoretical analysis. Radiology, 1980, 137(3): 679-686.
23. Kikuchi T, Nomura M, Tomita H, et al. Paroxysmal kinesigenic choreoathetosis (PKC): confirmation of linkage to 16p11-q21, but unsuccessful detection of mutations among 157 genes at the PKC-critical region in seven PKC families. J Hum Genet, 2007, 52(4): 334-341.
24. Bruno MK, Lee HY, Auburger GW, et al. Genotype-phenotype correlation of paroxysmal nonkinesigenic dyskinesia. Neurology, 2007, 68(21): 1782-1789.
25. Weber A, K?hler A, Hahn A, et al. Benign infantile convulsions (IC) and subsequent paroxysmal kinesigenic dyskinesia (PKD) in a patient with 16p11.2 microdeletion syndrome. Neurogenetics, 2013, 14(3-4): 251-253.
26. Waln O, Jankovic J. Paroxysmal movement disorders. Neurol Clin, 2015, 33(1): 137-152.
27. Tacik P, Loens S, Schrader C, et al. Severe familial paroxysmal exercise-induced dyskinesia. J Neurol, 2014, 261(10): 2009-2015.
28. Nobili L, Proserpio P, Combi R, et al. Nocturnal frontal lobe epilepsy. Curr Neurol Neurosci Rep, 2014, 14(2): 424.
29. Becchetti A, Aracri P, Meneghini S, et al. The role of nicotinic acetylcholine receptors in autosomal dominant nocturnal frontal lobe epilepsy. Front Physiol, 2015, 6(3): 22.
30. Liu XR, Huang D, Wang J, et al. Paroxysmal hypnogenic dyskinesia is associated with mutations in the PRRT2 gene. Neurol Genet, 2016, 2(2): e66.
31. Steinlein OK. Genetic heterogeneity in familial nocturnal frontal lobe epilepsy. Prog Brain Res, 2014, 213(6): 1-15.
32. Picard F, Makrythanasis P, Navarro V, et al. DEPDC5 mutations in families presenting as autosomal dominant nocturnal frontal lobe epilepsy. Neurology, 2014, 82(23): 2101-2106.

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Journal of Epilepsy

癲癇樣發作疾病的研究進展

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