Surgery for the treatment of encephalomalacia with secondary intractable epilepsy_Journal of Epilepsy

Authors：

 WANGHuanming , HUFei , SHAOQiang , CHENJun , XIAOKai , XIONGYubo , YANGYanping

Department of Neurosurgery, Wuhan Brain Hospital & Changhang General Hospital, Wuhan 430010, China;

Corresponding?author：

WANGHuanming, Email: 1808381741@qq.com

Keywords：

Encephalomalacia; Intractable epilepsy; Surgery

DOI：

10.7507/2096-0247.20160069

Video：

Export PDF Favorites Scan Get Citation

Abstract Full text Figures/Tables Video References Cited by

Objective To explore the strategy and outcome of surgery for the treatment of encephalomalacia with secondary intractable epilepsy. Method sDuring the period of July 2009 and June 2015, 21 cases of encephalomalacia with secondary intractable epilepsy were performed operation. Among them there were 16 males and 5 females. Their ages ranged from 4 to 34 years, with their illness duration from 3 to 14 years. According to the results of MRI and video-EEG monitoring, all the patients were performed operation under the monitoring of ECoG. And the outcome was graded by Engle scales for analysis. Result sECoG monitoring after the resection of encephalomalacia showed that there was still abnormal discharge. Enlarged cortical resection was performed in 10 cases, and cortical coagulation in 3、anterior temporal lobectomy + resection of the hippocampus and amygdala in 4、additional callosotomy in 4. The post-operative follow-up of 1~7 years showed that Grade Ⅰ was observed in 10 cases、Grade Ⅱ in 5 cases、Grade Ⅲ in 3 cases and Grade Ⅳ in 3 cases.The total surgical effectiveness was 85.7%. Conclusion To the patients of encephalomalacia with secondary intractable epilepsy, the epileptic lesion should be resected besides the resection of encephalomalacia. And the surgical effectiveness is satisfactory.

Citation： WANGHuanming, HUFei, SHAOQiang, CHENJun, XIAOKai, XIONGYubo, YANGYanping. Surgery for the treatment of encephalomalacia with secondary intractable epilepsy. Journal of Epilepsy, 2016, 2(5): 393-396. doi: 10.7507/2096-0247.20160069 Copy

1.	Lawn N, Londono A, Sawrie S, et al.Occipitoparietal epilepsy, hippocampal atrophy, and congenital developmental abnormalities. Epilepsia, 2000, 41(6):1546-1553.
2.	Lee YJ, Kim EH, Yum MS, et al. Long-term outcomes of hemispheric disconnection in pediatric patients with intractable epilepsy. J Clin Neurol, 2014, 10(2):101-107.
3.	孫吉林, 趙文清, 田中雨, 等.腦軟化灶FLAIR高信號與癲癇灶關系初探.中國臨床醫學影像雜志, 2009, 20(10):733-735.
4.	Wyllie E, Lachhwani DK, Gupta A, et al. Successful surgery for epilepsy due to early brain lesions despite generalized EEG findings. Neurology, 2007, 69(4):389-397.
5.	趙明, 梁樹立, 李安民, 等.局限性非外傷性腦軟化灶相關癲癇的手術治療.中華神經外科雜志, 2010, 26(6):500-502.
6.	劉琨, 王國棟, 張靜華, 等. PET輔助定位腦軟化灶伴發難治性癲癇的伽瑪刀治療中華神經醫學雜志, 2007, 6(12):1260-1264.
7.	王超, 劉窗溪, 熊云彪, 等.皮層腦電圖監測下多種術式聯合治療腦軟化灶所致的繼發性癲癇.山東醫藥, 2009, 49(26):19-20.
8.	Bennett-Back O, Ochi A, Widjaja E, et al. Magnetoencephalo-graphy helps delineate the extent of the epileptogenic zone for surgical planning in children with intractable epilepsy due to porencephaliccyst/encephalomalacia. J Neurosurg Pediatr, 2014, 14(3):271-278.

1. Lawn N, Londono A, Sawrie S, et al.Occipitoparietal epilepsy, hippocampal atrophy, and congenital developmental abnormalities. Epilepsia, 2000, 41(6):1546-1553.
2. Lee YJ, Kim EH, Yum MS, et al. Long-term outcomes of hemispheric disconnection in pediatric patients with intractable epilepsy. J Clin Neurol, 2014, 10(2):101-107.
3. 孫吉林, 趙文清, 田中雨, 等.腦軟化灶FLAIR高信號與癲癇灶關系初探.中國臨床醫學影像雜志, 2009, 20(10):733-735.
4. Wyllie E, Lachhwani DK, Gupta A, et al. Successful surgery for epilepsy due to early brain lesions despite generalized EEG findings. Neurology, 2007, 69(4):389-397.
5. 趙明, 梁樹立, 李安民, 等.局限性非外傷性腦軟化灶相關癲癇的手術治療.中華神經外科雜志, 2010, 26(6):500-502.
6. 劉琨, 王國棟, 張靜華, 等. PET輔助定位腦軟化灶伴發難治性癲癇的伽瑪刀治療中華神經醫學雜志, 2007, 6(12):1260-1264.
7. 王超, 劉窗溪, 熊云彪, 等.皮層腦電圖監測下多種術式聯合治療腦軟化灶所致的繼發性癲癇.山東醫藥, 2009, 49(26):19-20.
8. Bennett-Back O, Ochi A, Widjaja E, et al. Magnetoencephalo-graphy helps delineate the extent of the epileptogenic zone for surgical planning in children with intractable epilepsy due to porencephaliccyst/encephalomalacia. J Neurosurg Pediatr, 2014, 14(3):271-278.

Journal of Epilepsy

Surgery for the treatment of encephalomalacia with secondary intractable epilepsy

Abstract Full text Figures/Tables Video References Cited by

Previous Article

Next Article

Format

Content