Brucea Javanica Oil Emulsion in Treatment of Malignant Pleural Effusion: A Meta-Analysis_Chinese Journal of Evidence-Based Medicine

Authors：

 WEIKong-ping ^1,2 ,  WANGQi-tuan ³ , WANGQi-rong ¹ , WEIKong-yuan ¹ , JINYan-ling ¹ , SUNYu ¹ , SHAOLi-li ¹ , WANGQuan ¹ , TIANJin-hui ¹

1. Evidence-based Medicine Center, Lanzhou University, Lanzhou 730000, China;
2. Second Hospital of Lanzhou University, Lanzhou 730000, China;
3. Department of Pediatrics, Academic Department of Zhejiang Jiuxu Pharmaceutical Co, LTD, Jinhua 321016, China;

Corresponding?author：

WANGQi-tuan, Email: zjjxwqt@126.com

Keywords：

Brucea javanica oil emulsion; Malignant pleural effusion; Meta-analysis; Systematic review; Randomized controlled trial

DOI：

10.7507/1672-2531.20140203

Video：

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Objective To systematically review the efficacy and safety of brucea javanica oil emulsion with/without cisplatin in the treatment of malignant pleural effusion (MPE). Methods We electronically search PubMed, The Cochrane Library (Issue 6, 2013), EMbase, CBM, WanFang Data, VIP and CNKI to collect randomized controlled trial about brucea javanica oil emulsion for MPE from the establishment dates to June 2013. According to the inclusion and exclusion criteria, two reviewers independently screened literature, extracted data, and assessed the methodological quality of included studies. Then meta-analysis was performed using RevMan 5.1 software. Results A total of twenty-five RCTs involving 1 620 patients were included. The results of meta-analysis showed that:compared with using cisplatin alone, brucea javanica oil emulsion plus cisplatin could improve clinical efficiency (RR=1.45, 95%CI 1.34 to 1.57, P < 0.000 01) and patients' quality of life (RR=1.36, 95%CI 1.18 to 1.56, P < 0.000 1), and relieved the incidences of bone marrow depression (OR=0.31, 95%CI 0.22 to 0.42, P < 0.000 01) and digestive tract reaction (OR=0.36, 95%CI 0.24 to 0.54, P < 0.000 01, ) and fever (OR=0.18, 95%CI 0.08 to 0.40, P < 0.000 1). Conclusion Current evidence indicates that brucea javanica oil emulsion could improve chemotherapy effects MPE. However, due to the limited quality of the included studies, more high quality studies with large sample size are needed to verify the conclusion.

Citation： WEIKong-ping, WANGQi-tuan, WANGQi-rong, WEIKong-yuan, JINYan-ling, SUNYu, SHAOLi-li, WANGQuan, TIANJin-hui. Brucea Javanica Oil Emulsion in Treatment of Malignant Pleural Effusion: A Meta-Analysis. Chinese Journal of Evidence-Based Medicine, 2014, 14(10): 1263-1269. doi: 10.7507/1672-2531.20140203 Copy

1.	嚴文躍, 錢曉萍, 劉寶瑞.惡性胸腔積液的治療進展.現代腫瘤醫學, 2009, 17(7):1393-1396.
2.	Am J. Managment of malignant pleural effusions. Respire Crit Care Med, 2000, 162(5):987.
3.	吳一龍.肺癌多學科綜合治療的理論與實踐.北京:人民衛生出版社, 2000:277.
4.	孫慨, 魏桂珍, 王亞湘.鴉膽子乳加化療治療晚期肺癌療效觀察.中國中西醫結合雜志, 1994, 14(2):108.
5.	Higgins JPT, Green S. Cochrane Handbook for Systematic Reviews of Interventions Version5. 1. 0[updated March 2011]. The Cochrane Collaboration, 2011. Available at:www.Cochrane-handbook.org.
6.	付相建, 尚志, 楊光華, 等.導管持續引流聯合鴉膽子油乳、順鉑治療惡性胸腔積液的療效觀察.臨床軍醫雜志, 2009, 37(5):818-820.
7.	陳勇.鴉膽子油乳聯合順鉑治療惡性胸腔積液療效觀察.浙江中西醫結合雜志, 2011, 21(17):713-714.
8.	王懇, 龍鑫.胸腔內灌注鴉膽子油乳劑與順鉑治療肺癌導致惡性胸腔積液療效比較.中國醫藥, 2010, 5(6):513-514.
9.	吉佑華.順鉑聯合鴉膽子油乳腔內治療30例惡性胸腔積液.腫瘤學雜志, 2009, 15(5):474-475.
10.	高作文, 姜金書, 丁太良, 等.鴨膽子油乳聯合順鉑及白細胞介素-Ⅱ治療肺癌惡性胸腔積液臨床觀察.中國腫瘤臨床與康復, 2013, 20(2):153-154.
11.	尤建良, 薛青, 趙義純.鴉膽子乳胸腔內注射治療癌性胸水臨床研究.長春中醫學院學報, 2001, 17(3):11-12.
12.	吳共國.鴉膽子油乳聯合順鉑胸腔內灌注治療癌性胸水92例療效觀察.醫藥前沿, 2012, 2(19):211.
13.	王紅梅, 廖國清, 劉鵬輝, 等.鴉膽子油乳注射液聯合順鉑治療肺癌胸水70例.中國腫瘤, 2007, 16(12):1035-1036.
14.	駱明蓮, 程宏文.鴉膽子油乳聯合順鉑治療惡性胸腔積液臨床觀察.中國基層醫藥, 2011, 18(3):293-294.
15.	柳寶, 張麗敏.鴉膽子油乳聯合順鉑胸腔內灌注治療肺癌所致惡性胸腔積液的療效觀察.中國當代醫藥, 2012, 19(7):48-47.
16.	吳述洪, 芮磊, 洪原城.鴉膽子油乳聯合順鉑胸腔注射治療癌性胸水68例療效觀察.海南醫學, 2009, 20(9):14-15.
17.	楊潔, 何琳.鴉膽子油乳聯合順鉑腔內注射治療癌性胸水.河南腫瘤學雜志, 2002, 15(4):281-282.
18.	郭彥偉, 吳建有, 楊河川, 等.鴉膽子油乳聯合順鉑腔內注入治療惡性胸腔積液.腫瘤學雜志, 2004, 10(2):129-130.
19.	宋應健, 王立新, 洪永青, 等.鴉膽子油乳劑聯合順鉑治療惡性胸腔積液的療效.江蘇醫藥, 2011, 37(21):2527-2528.
20.	莫紹雄, 楊小平, 趙文, 等.鴉膽子油乳劑聯合順鉑胸腔灌注治療癌性胸水療效觀察.浙江中西醫結合雜志, 2009, 19(11):683-684.
21.	張昊, 靳端陽, 趙燕.鴉膽子油乳聯合順鉑治療惡性胸腔積液34例.中國中醫藥現代遠程教育, 2013, 11(5):41-42.
22.	楊曉慧, 郝培.鴉膽子油乳聯合順鉑治療惡性胸腔積液療效觀察.山東醫藥, 2005, 45(16):68-69.
23.	羅俊華.鴉膽子油乳治療惡性胸腔積液臨床療效回顧性分析.醫學理論與實踐, 2013, 26(25):609-610.
24.	錢祥夕.鴉膽子油乳胸腔灌注治療惡性胸腔積液臨床觀察.山東醫藥, 2011, 51(28):14.
25.	陳成宏, 李宏斌, 李迎春, 等.鴉膽子油乳注射液聯合伽瑪刀治療癌性胸水療效觀察.現代腫瘤醫學, 2009, 17(6):1092-1093.
26.	陳上民, 肖震宇.鴉膽子油乳胸腔灌注治療癌性胸水臨床研究.贛南醫學院學報, 2005, 25(6):837.
27.	蘇忠, 張靜, 任興帥.鴉膽子油乳胸腔灌注治療惡性胸腔積液30例臨床觀察.醫學信息(中旬刊), 2011, 24(8):3946.
28.	何學軍, 崔林.鴉膽子油乳劑與順鉑治療惡性胸腔積液的療效比較.腫瘤研究與臨床, 2006, 18(11):777-778.
29.	李楊.使用鴉膽子油乳靜滴聯合腔內注射或順鉑腔內注射治療胸腔積液的觀察.內蒙古中醫藥, 2010, 29(23):27-28.
30.	李猛, 余少娜.鴉膽子油乳劑聯合熱療治療惡性胸腔積液的臨床觀察.中華臨床醫師雜志, 2011, 5(11):3337-3338.
31.	曾普華, 蔣益蘭, 蔡美, 等.鴉膽子油乳經胸腔熱灌注治療惡性胸腔積液的臨床研究.湖南中醫藥大學學報, 2011, 31(5):51-53.
32.	邢秋月, 賈晨光, 劉欣燕, 等.鴉膽子油乳注射液治療晚期非小細胞肺癌療效觀察.河北醫藥, 2008, 30(7):963-964.
33.	張玲娟, 蘇娟, 彭菊聰, 等.白細胞介素-2聯合順鉑與順鉑胸腔內注射治療惡性胸腔積液的有效性和安全性的Meta分析.中國循證醫學雜志, 2010, (增刊):132.
34.	劉莉, 趙艷, 孫甜甜, 等.胸腔內注射白細胞介素-2與順鉑治療惡性胸腔積液有效性和安全性的系統評價.中國循證醫學雜志, 2010, (增刊):132-133.

1. 嚴文躍, 錢曉萍, 劉寶瑞.惡性胸腔積液的治療進展.現代腫瘤醫學, 2009, 17(7):1393-1396.
2. Am J. Managment of malignant pleural effusions. Respire Crit Care Med, 2000, 162(5):987.
3. 吳一龍.肺癌多學科綜合治療的理論與實踐.北京:人民衛生出版社, 2000:277.
4. 孫慨, 魏桂珍, 王亞湘.鴉膽子乳加化療治療晚期肺癌療效觀察.中國中西醫結合雜志, 1994, 14(2):108.
5. Higgins JPT, Green S. Cochrane Handbook for Systematic Reviews of Interventions Version5. 1. 0[updated March 2011]. The Cochrane Collaboration, 2011. Available at:www.Cochrane-handbook.org.
6. 付相建, 尚志, 楊光華, 等.導管持續引流聯合鴉膽子油乳、順鉑治療惡性胸腔積液的療效觀察.臨床軍醫雜志, 2009, 37(5):818-820.
7. 陳勇.鴉膽子油乳聯合順鉑治療惡性胸腔積液療效觀察.浙江中西醫結合雜志, 2011, 21(17):713-714.
8. 王懇, 龍鑫.胸腔內灌注鴉膽子油乳劑與順鉑治療肺癌導致惡性胸腔積液療效比較.中國醫藥, 2010, 5(6):513-514.
9. 吉佑華.順鉑聯合鴉膽子油乳腔內治療30例惡性胸腔積液.腫瘤學雜志, 2009, 15(5):474-475.
10. 高作文, 姜金書, 丁太良, 等.鴨膽子油乳聯合順鉑及白細胞介素-Ⅱ治療肺癌惡性胸腔積液臨床觀察.中國腫瘤臨床與康復, 2013, 20(2):153-154.
11. 尤建良, 薛青, 趙義純.鴉膽子乳胸腔內注射治療癌性胸水臨床研究.長春中醫學院學報, 2001, 17(3):11-12.
12. 吳共國.鴉膽子油乳聯合順鉑胸腔內灌注治療癌性胸水92例療效觀察.醫藥前沿, 2012, 2(19):211.
13. 王紅梅, 廖國清, 劉鵬輝, 等.鴉膽子油乳注射液聯合順鉑治療肺癌胸水70例.中國腫瘤, 2007, 16(12):1035-1036.
14. 駱明蓮, 程宏文.鴉膽子油乳聯合順鉑治療惡性胸腔積液臨床觀察.中國基層醫藥, 2011, 18(3):293-294.
15. 柳寶, 張麗敏.鴉膽子油乳聯合順鉑胸腔內灌注治療肺癌所致惡性胸腔積液的療效觀察.中國當代醫藥, 2012, 19(7):48-47.
16. 吳述洪, 芮磊, 洪原城.鴉膽子油乳聯合順鉑胸腔注射治療癌性胸水68例療效觀察.海南醫學, 2009, 20(9):14-15.
17. 楊潔, 何琳.鴉膽子油乳聯合順鉑腔內注射治療癌性胸水.河南腫瘤學雜志, 2002, 15(4):281-282.
18. 郭彥偉, 吳建有, 楊河川, 等.鴉膽子油乳聯合順鉑腔內注入治療惡性胸腔積液.腫瘤學雜志, 2004, 10(2):129-130.
19. 宋應健, 王立新, 洪永青, 等.鴉膽子油乳劑聯合順鉑治療惡性胸腔積液的療效.江蘇醫藥, 2011, 37(21):2527-2528.
20. 莫紹雄, 楊小平, 趙文, 等.鴉膽子油乳劑聯合順鉑胸腔灌注治療癌性胸水療效觀察.浙江中西醫結合雜志, 2009, 19(11):683-684.
21. 張昊, 靳端陽, 趙燕.鴉膽子油乳聯合順鉑治療惡性胸腔積液34例.中國中醫藥現代遠程教育, 2013, 11(5):41-42.
22. 楊曉慧, 郝培.鴉膽子油乳聯合順鉑治療惡性胸腔積液療效觀察.山東醫藥, 2005, 45(16):68-69.
23. 羅俊華.鴉膽子油乳治療惡性胸腔積液臨床療效回顧性分析.醫學理論與實踐, 2013, 26(25):609-610.
24. 錢祥夕.鴉膽子油乳胸腔灌注治療惡性胸腔積液臨床觀察.山東醫藥, 2011, 51(28):14.
25. 陳成宏, 李宏斌, 李迎春, 等.鴉膽子油乳注射液聯合伽瑪刀治療癌性胸水療效觀察.現代腫瘤醫學, 2009, 17(6):1092-1093.
26. 陳上民, 肖震宇.鴉膽子油乳胸腔灌注治療癌性胸水臨床研究.贛南醫學院學報, 2005, 25(6):837.
27. 蘇忠, 張靜, 任興帥.鴉膽子油乳胸腔灌注治療惡性胸腔積液30例臨床觀察.醫學信息(中旬刊), 2011, 24(8):3946.
28. 何學軍, 崔林.鴉膽子油乳劑與順鉑治療惡性胸腔積液的療效比較.腫瘤研究與臨床, 2006, 18(11):777-778.
29. 李楊.使用鴉膽子油乳靜滴聯合腔內注射或順鉑腔內注射治療胸腔積液的觀察.內蒙古中醫藥, 2010, 29(23):27-28.
30. 李猛, 余少娜.鴉膽子油乳劑聯合熱療治療惡性胸腔積液的臨床觀察.中華臨床醫師雜志, 2011, 5(11):3337-3338.
31. 曾普華, 蔣益蘭, 蔡美, 等.鴉膽子油乳經胸腔熱灌注治療惡性胸腔積液的臨床研究.湖南中醫藥大學學報, 2011, 31(5):51-53.
32. 邢秋月, 賈晨光, 劉欣燕, 等.鴉膽子油乳注射液治療晚期非小細胞肺癌療效觀察.河北醫藥, 2008, 30(7):963-964.
33. 張玲娟, 蘇娟, 彭菊聰, 等.白細胞介素-2聯合順鉑與順鉑胸腔內注射治療惡性胸腔積液的有效性和安全性的Meta分析.中國循證醫學雜志, 2010, (增刊):132.
34. 劉莉, 趙艷, 孫甜甜, 等.胸腔內注射白細胞介素-2與順鉑治療惡性胸腔積液有效性和安全性的系統評價.中國循證醫學雜志, 2010, (增刊):132-133.

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Brucea Javanica Oil Emulsion in Treatment of Malignant Pleural Effusion: A Meta-Analysis

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