HLA-G基因14 bp插入/缺失多態性與子癇前期相關性的Meta分析_《中國循證醫學雜志》

作者：

沈彥婷 ¹ ,  于紅 ¹ , 王蓓 ²

1. 東南大學附屬中大醫院婦產科（南京 210009）；2. 東南大學公共衛生學院（南京 210009）;

關鍵詞：

子癇前期 HLA-G 多態性系統評價 Meta分析病例-對照研究

DOI：

10.7507/1672-2531.20130167

視頻：

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目的　系統評價HLA-G基因3’非編碼區14 bp插入/缺失多態性與子癇前期的相關性。
方法　計算機檢索PubMed、Web of Science、EMbase、CBM、CNKI、WanFang Data、VIP，收集2012年5月以前國內外公開發表的有關妊娠婦女及其配偶、后代HLA-G 14 bp插入/缺失多態性與子癇前期相關性的病例-對照研究。由兩位研究者按照納入與排除標準獨立篩選文獻、提取資料和評價質量后，采用RevMan 5.1軟件進行Meta分析。
結果　最終納入10篇文獻。Meta分析結果顯示：子癇前期組父親與子代的HLA-G+14 bp基因單倍型頻率以及父親+14 bp/+14 bp基因型頻率明顯高于正常對照組，子代HLA-G ?14 bp基因單倍型頻率低于正常妊娠組。其合并OR值及其95%CI分別為1.42（1.10，1.84）、1.54（1.25，1.90）、2.00（1.19，3.38）、0.67（0.54，0.82）。子癇前期組子代+14 bp/+14 bp基因型頻率明顯高于正常對照組，?14 bp/?14 bp基因型頻率明顯低于正常對照組［OR=1.75，95%CI（1.11，2.77）；OR=0.57，95%CI（0.41，0.81）］。子癇前期組，母（?14 bp/?14 bp）/子（?14 bp/?14 bp）基因型配伍頻率顯著低于正常妊娠組［OR=0.52；95%CI（0.31，0.85）］，而母（+14 bp/?14 bp）/子（+14 bp/+14 bp）基因型配伍頻率顯著高于正常妊娠組［OR=3.77；95%CI（1.40，10.11）］；父（?14 bp/?14 bp）/子（?14 bp/?14 bp）基因型配伍頻率顯著低于正常妊娠組［OR=0.33，95%CI（0.15，0.75）］。
結論　父親和子代HLA-G 14 bp插入/缺失多態性與子癇前期存在相關性，母子基因型配伍分析可為子癇前期病因研究與臨床診治提供新線索。

引用本文： 沈彥婷,于紅,王蓓. HLA-G基因14 bp插入/缺失多態性與子癇前期相關性的Meta分析. 中國循證醫學雜志, 2013, 13(8): 955-962. doi: 10.7507/1672-2531.20130167 復制

1.	Walker JJ. Preeclampsia. The Lancet, 2000, 356(9237): 1260-1265.
2.	Murphy DJ, Striate GM. Mortality and morbidity associated with early onset preeclampsia. Hypertens Pregnancy, 2000, 19(2): 221.
3.	李澤均, 劉興會, 何國琳, 等. 重度子癇前期早產與自發性早產母兒結局的比較研究. 中國循證醫學雜志, 2010, 10(9): 1016-1022.
4.	Hviid TV. HLA-G in human reproduction:Aspects of genetics, function and pregnancy complications. Hum Repmd Update, 2006, 12(3): 2.
5.	豐有吉, 主編. 婦產科學. 第七版. 北京: 人民衛生出版社, 2005: 74-84.
6.	Ownby RL, Crocco E, Acevedo A, et al. Depression and risk for Alzheimer disease: systematic review, meta-analysis, and metaregression analysis. Arch Gen Psychiatry, 2006, 63(5): 530-538.
7.	Zhang Z, Li Y, Zhang LL, et al. Association of 14 bp insertion/deletion polymorphism of the HLA-G gene in father with severe preeclampsia in Chinese. Tissue Antigens, 2012, 80(2): 158-164.
8.	Iversen AC, Nguyen OTD, Tømmerdal LF, et al. The HLA-G 14 bp gene polymorphism and decidual HLA-G14 bp gene expression in pre-eclamptic and normal pregnancies. Journal of Reproductive Immunology, 2008, 78(2): 158-165.
9.	Vianna P, Dalmaz CA, Veit TD, et al. Immunogenetics of pregnancy: Role of a 14-bp deletion in the maternal HLA-G gene in primiparous pre-eclamptic Brazilian women. Human Immunology, 2007, 68(8), 668-674.
10.	Lin A, Yan WH, Dai MZ, et al. Maternal human leukocyte antigen-G polymorphism is not associated with pre-eclampsia in a Chinese Han population. Tissue Antigens, 2008, 68(4): 311-316.
11.	Hylenius S, Andersen AMN, Melbye M, et al. Association between HLA-G genotype and risk of preeclampsia: a case±control study using family triads. Molecular Human Reproduction, 2004, 10(4): 237-246.
12.	Bermingham J, Jenkins D, McCarthy T, et al. Genetic analysis of insulin-like growth factor II and HLA-G in pre-eclampsia. Biochemical Society Transactions, 2000, 28(2): 215-219.
13.	Humphrey KE, Harrison GA, Cooper DW, et al. HLA-G deletion polymorphism and preeclampsia/ eclampsia. British Journal of Obstetrics and Gynaecology, 1995, 102(9): 707-710.
14.	張展, 李瑩, 張琳琳, 等. 父源性 HLA-G基因14 bp缺失多態性與早發型重度子癇前期的相關性研究. 中國婦幼保健, 2012, 27(11): 1710-1713.
15.	李紅, 張琳琳, 賈莉婷, 等. 母兒中HLA-G 14 bp插人／缺失多態性在早發型、晚發型重度子癇前期和正常妊娠中分布的差異.現代婦產科進展, 2011, 20(3): 203-206.
16.	張展, 王婧彥, 張琳琳, 等. 人類白細胞抗原G基因14 bp缺失多態性與重度子癇前期發病的關系. 中華婦產科雜志, 2010, 45(5): 348-352.
17.	Ahn H, Park J, Gilman-Sachs A, et al. Immunologic Characteristics of Preeclampsia, a Comprehensive Review. Am J Reprod Immunol, 2011, 65(4): 377-394.
18.	Servitje EL, Lopez NG, Olson DM. An immunological insight into the origins of preeclampsia. Hum Reprod Update, 2010, 16(5): 510-524.
19.	Uzan J, Carbonne M, Piconne O, et al. Pre-eclampsia: pathophysiology, diagnosis,and management. Vasc Health Risk Manag, 2011, 7: 467-474.
20.	Servitje EL, Lopez NG, Olson DM. An immunological insight into the origins of preeclampsia. Hum Reprod Update, 2010, 16(5): 510-524.
21.	Favier B, LeMaoult J, Lesport E, et al. ILT2/HLA-G interaction impairs NK-cell functions through the inhibition of the late but not the early events of the NK-cell activating synapse. Faseb J, 2010, 24(3): 689–699.

1. Walker JJ. Preeclampsia. The Lancet, 2000, 356(9237): 1260-1265.
2. Murphy DJ, Striate GM. Mortality and morbidity associated with early onset preeclampsia. Hypertens Pregnancy, 2000, 19(2): 221.
3. 李澤均, 劉興會, 何國琳, 等. 重度子癇前期早產與自發性早產母兒結局的比較研究. 中國循證醫學雜志, 2010, 10(9): 1016-1022.
4. Hviid TV. HLA-G in human reproduction:Aspects of genetics, function and pregnancy complications. Hum Repmd Update, 2006, 12(3): 2.
5. 豐有吉, 主編. 婦產科學. 第七版. 北京: 人民衛生出版社, 2005: 74-84.
6. Ownby RL, Crocco E, Acevedo A, et al. Depression and risk for Alzheimer disease: systematic review, meta-analysis, and metaregression analysis. Arch Gen Psychiatry, 2006, 63(5): 530-538.
7. Zhang Z, Li Y, Zhang LL, et al. Association of 14 bp insertion/deletion polymorphism of the HLA-G gene in father with severe preeclampsia in Chinese. Tissue Antigens, 2012, 80(2): 158-164.
8. Iversen AC, Nguyen OTD, Tømmerdal LF, et al. The HLA-G 14 bp gene polymorphism and decidual HLA-G14 bp gene expression in pre-eclamptic and normal pregnancies. Journal of Reproductive Immunology, 2008, 78(2): 158-165.
9. Vianna P, Dalmaz CA, Veit TD, et al. Immunogenetics of pregnancy: Role of a 14-bp deletion in the maternal HLA-G gene in primiparous pre-eclamptic Brazilian women. Human Immunology, 2007, 68(8), 668-674.
10. Lin A, Yan WH, Dai MZ, et al. Maternal human leukocyte antigen-G polymorphism is not associated with pre-eclampsia in a Chinese Han population. Tissue Antigens, 2008, 68(4): 311-316.
11. Hylenius S, Andersen AMN, Melbye M, et al. Association between HLA-G genotype and risk of preeclampsia: a case±control study using family triads. Molecular Human Reproduction, 2004, 10(4): 237-246.
12. Bermingham J, Jenkins D, McCarthy T, et al. Genetic analysis of insulin-like growth factor II and HLA-G in pre-eclampsia. Biochemical Society Transactions, 2000, 28(2): 215-219.
13. Humphrey KE, Harrison GA, Cooper DW, et al. HLA-G deletion polymorphism and preeclampsia/ eclampsia. British Journal of Obstetrics and Gynaecology, 1995, 102(9): 707-710.
14. 張展, 李瑩, 張琳琳, 等. 父源性 HLA-G基因14 bp缺失多態性與早發型重度子癇前期的相關性研究. 中國婦幼保健, 2012, 27(11): 1710-1713.
15. 李紅, 張琳琳, 賈莉婷, 等. 母兒中HLA-G 14 bp插人／缺失多態性在早發型、晚發型重度子癇前期和正常妊娠中分布的差異.現代婦產科進展, 2011, 20(3): 203-206.
16. 張展, 王婧彥, 張琳琳, 等. 人類白細胞抗原G基因14 bp缺失多態性與重度子癇前期發病的關系. 中華婦產科雜志, 2010, 45(5): 348-352.
17. Ahn H, Park J, Gilman-Sachs A, et al. Immunologic Characteristics of Preeclampsia, a Comprehensive Review. Am J Reprod Immunol, 2011, 65(4): 377-394.
18. Servitje EL, Lopez NG, Olson DM. An immunological insight into the origins of preeclampsia. Hum Reprod Update, 2010, 16(5): 510-524.
19. Uzan J, Carbonne M, Piconne O, et al. Pre-eclampsia: pathophysiology, diagnosis,and management. Vasc Health Risk Manag, 2011, 7: 467-474.
20. Servitje EL, Lopez NG, Olson DM. An immunological insight into the origins of preeclampsia. Hum Reprod Update, 2010, 16(5): 510-524.
21. Favier B, LeMaoult J, Lesport E, et al. ILT2/HLA-G interaction impairs NK-cell functions through the inhibition of the late but not the early events of the NK-cell activating synapse. Faseb J, 2010, 24(3): 689–699.

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HLA-G基因14 bp插入/缺失多態性與子癇前期相關性的Meta分析

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HLA-G基因14 bp插入/缺失多態性與子癇前期相關性的Meta分析

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