TERC基因對宮頸高級別病變（≥CINⅡ）診斷價值的Meta分析_《中國循證醫學雜志》

作者：

歐亞夢蘭 , 李力 ,  高琨

廣西醫科大學附屬腫瘤醫院婦瘤科（南寧 530021）;

關鍵詞：

TERC基因宮頸癌 Meta分析系統評價診斷性試驗

DOI：

10.7507/1672-2531.20130056

視頻：

導出 下載 收藏 掃碼 引用

摘要 全文 圖表 視頻 參考文獻 施引文獻 補充材料

目的　系統評價TERC基因對宮頸高級別病變（≥CINⅡ）的診斷價值。
方法　計算機檢索PubMed、EMbase、The Cochrane Library等數據庫，檢索時間截至2012年3月31日。按照納入和排除標準篩選文獻、提取資料并根據診斷性試驗準確性質量評價工具（QUADAS）評價質量后，采用Meta-Disc 1.4軟件進行Meta分析。
結果　最終納入12篇文獻，共7 894例患者。Meta分析結果顯示：TERC基因診斷宮頸高級別病變的合并靈敏度、特異度和診斷比值比分別為0.81［95%CI（0.80，0.82）］、0.83［95%CI（0.82，0.84）］和17.37［95%CI（8.77，34.41）］。
結論　TERC基因單獨檢測宮頸高級別病變的診斷價值中等，可作為臨床診斷的一種輔助方法。

引用本文： 歐亞夢蘭,李力,高琨. TERC基因對宮頸高級別病變（≥CINⅡ）診斷價值的Meta分析. 中國循證醫學雜志, 2013, 13(3): 325-331. doi: 10.7507/1672-2531.20130056 復制

1.	李克敏, 尹如鐵. 人類乳頭狀病毒檢測診斷宮頸癌前病變的價值: 隨機對照研究的系統評價. 中國循證醫學雜志, 2011, 11(8): 910-918.
2.	Heselmeyer-Haddad K, Janz V, Castle PE, et al. Detection of Genomic Amplification of the Human Telomerase Gene (TERC) in Cytologic Specimens as a Genetic Test for the Diagnosis of Cervical. Dysplasia American Journal of Patholog, 2003, 163: 1406-1416.
3.	Heselmever-Haddad K, Sommerfeld K, White NM, et al. Genomic Amplification of the Human Telomerase Gene (TERC) in Pap Smears Predicts the Development of Cervical Cancer. American Journal of Pathology, 2005, 166: 1229-1238.
4.	Naney RC, Craway AK, Marilyn D, et al. Gain of the 3q26 region incervicovaginal liquid-based pap preparations is associated with squamous intraepithelial lesions and squamous cell carcinoma. Gynecologic Oncology, 2008, 110: 37-42.
5.	Costa C, EsPinet B, Molina MA, et al. Analysis of gene status in cervical dysplastic lesions and squamous cell carcinoma using tissue microarrays. Histol Histopathol, 2009, 24(7): 821-829.
6.	Yuan YL, He CN, Xu MT, et al. Detection of TERC gene amplification by fluorescence in-situ hybridization in cervical intraepithelial lesions. Chinese Journal of Pathology, 2011, 40(3): 182-186.
7.	Jiang J, Wei LH, Li YL, et al. Detection of TERC amplification in cervical epithelial cells for the diagnosis of high-grade cervical lesions and invasive cancer: a multicenter study in China. J Mol Diagn, 2010, 12(6): 808-817.
8.	Voss JS, Kipp BR, Campion MB, et al. Assessment of fluorescence in situ hybridization and hybrid capture 2 analyses of cervical cytology specimens diagnosed as low grade squamous intraepithelial lesion for the detection of high grade cervical intraepithelial neoplasia. Anal Quant Cytol Histol, 2010, 32(3): 121-130.
9.	Andersson S, Sowjanya P, Wangsa D, et al. Detection of genomic amplification of the human telomerase gene TERC, a potential marker for triage of women with HPV-positive, abnormal Pap smears. Am J Pathol, 2009, 175(5): 1831-1847.
10.	Kokalj-Vokac N, Kodric T, Erjavec-Skerget A, et al. Screening of TERC gene amplification as an additional genetic diagnostic test in detection of cervical preneoplastic lesions. Cancer Genet Cytogenet, 2009, 195(1): 19-22.
11.	Wisman GB, De Jong S, Meersma GJ, et al. Telomerase in (pre)neoplastic cervical disease. Hum Pathol, 2000, 31(10): 1304-1312.
12.	Theelen W, Speel EJ, Herfs M, et al. Increase in viral load, viral integration, and gain of telomerase genes during uterine cervical carcinogenesis can be simultaneously assessed by the HPV 16/18 MLPA-assay. Am J Pathol, 2010, 177(4): 2022-2033.
13.	Zhang Y, Wang X, Ma L, et al. Clinical significance of hTERC gene amplification detection by FISH in the screening of cervical lesions. J Huazhong Univ Sci Technolog Med Sci, 2009, 29(3): 368-371.
14.	Reesink-Peters N, Helder MN, Wisman GB, et al. Detection of telomerase, its components, and human papillomavirus in cervical scrapings as a tool for triage in women with cervical dysplasia. J Clin Pathol, 2003, 56(1): 31-35.
15.	Lanham S, Herbert A, Watt P. HPV detection and measurement of HPV-16, telomerase, and survivin transcripts in colposcopy clinic patients. J Clin Pathol, 2001, 54(4): 304-308.
16.	Riethdorf S, Riethdorf L, Schulz G, et al. Relationship between telomerase activation and HPV 16/18 oncogene expression in squamous intraepithelial lesions and squamous cell carcinomas of the uterine cervix. Int J Gynecol Pathol, 2001, 20(2): 177-185.
17.	Li Y, Zeng WJ, Ye F, et al. Application of hTERC in thinprep samples with mild cytologic abnormality and HR-HPV positive. Gynecologic Oncology, 2011, 120(1): 73-83.
18.	Whiting P, Rutjes AW, Reitsma JB, et al. The development of QUADAS: a tool for the quality assessment of studies of diagnostic accuracy included in systematic reviews. BMC Med Res Method, 2003, 10(3): 25.
19.	Lee DK, Kim BC, Kim IY, et al. The human papilloma virus E7 oncoprotein inhibits transforming growth factor-be-tasignaling by blocking binding of the Smad complex toits target sequence. J Biol Chem, 2002, 277(4): 38557-38564.
20.	Favre Bonvin A, Reynaud C, Kretz Remy C, et al. Human Papilloma virus type 18 E6 protein binds the cellular PDZ protein TIP-2/GIPC, which is involved in transforming growth factor beta signaling and triggem its degradation by the proteasome. J Virol, 2005, 79: 4229-4237.
21.	Mark RP, Trent H, Roger DP, et al. Selection of cervical keratinocytes containing integrated HPV16 associates with episome loss and an endogenous antiviral response. PNAS, 2006, 103(10): 3822-3827.
22.	Caraway NP, Khanna A, Dawlett M, et al. Gain of the 3q26 regin in cervicovaginal liquid-based pap preparations is associated with squamous intraepithelial lesions and squamous cell carcinoma. Gynecol Oncol, 2008, 110(1): 37-42.
23.	李靜然, 魏麗惠. 應用雙色間期FISH技術中宮頸脫落細胞取材及制片方法的探討. 中國婦產科臨床雜志, 2007, 8(6): 435-438.
24.	Ramsaroop R, Oei P, Ng D, et al. Cervical intraepithelial neoplasia and aneusomy of TERC: assessment of liquid-based cytological preparations. Diagn Cytopathol, 2009, 37(6): 411-415.

1. 李克敏, 尹如鐵. 人類乳頭狀病毒檢測診斷宮頸癌前病變的價值: 隨機對照研究的系統評價. 中國循證醫學雜志, 2011, 11(8): 910-918.
2. Heselmeyer-Haddad K, Janz V, Castle PE, et al. Detection of Genomic Amplification of the Human Telomerase Gene (TERC) in Cytologic Specimens as a Genetic Test for the Diagnosis of Cervical. Dysplasia American Journal of Patholog, 2003, 163: 1406-1416.
3. Heselmever-Haddad K, Sommerfeld K, White NM, et al. Genomic Amplification of the Human Telomerase Gene (TERC) in Pap Smears Predicts the Development of Cervical Cancer. American Journal of Pathology, 2005, 166: 1229-1238.
4. Naney RC, Craway AK, Marilyn D, et al. Gain of the 3q26 region incervicovaginal liquid-based pap preparations is associated with squamous intraepithelial lesions and squamous cell carcinoma. Gynecologic Oncology, 2008, 110: 37-42.
5. Costa C, EsPinet B, Molina MA, et al. Analysis of gene status in cervical dysplastic lesions and squamous cell carcinoma using tissue microarrays. Histol Histopathol, 2009, 24(7): 821-829.
6. Yuan YL, He CN, Xu MT, et al. Detection of TERC gene amplification by fluorescence in-situ hybridization in cervical intraepithelial lesions. Chinese Journal of Pathology, 2011, 40(3): 182-186.
7. Jiang J, Wei LH, Li YL, et al. Detection of TERC amplification in cervical epithelial cells for the diagnosis of high-grade cervical lesions and invasive cancer: a multicenter study in China. J Mol Diagn, 2010, 12(6): 808-817.
8. Voss JS, Kipp BR, Campion MB, et al. Assessment of fluorescence in situ hybridization and hybrid capture 2 analyses of cervical cytology specimens diagnosed as low grade squamous intraepithelial lesion for the detection of high grade cervical intraepithelial neoplasia. Anal Quant Cytol Histol, 2010, 32(3): 121-130.
9. Andersson S, Sowjanya P, Wangsa D, et al. Detection of genomic amplification of the human telomerase gene TERC, a potential marker for triage of women with HPV-positive, abnormal Pap smears. Am J Pathol, 2009, 175(5): 1831-1847.
10. Kokalj-Vokac N, Kodric T, Erjavec-Skerget A, et al. Screening of TERC gene amplification as an additional genetic diagnostic test in detection of cervical preneoplastic lesions. Cancer Genet Cytogenet, 2009, 195(1): 19-22.
11. Wisman GB, De Jong S, Meersma GJ, et al. Telomerase in (pre)neoplastic cervical disease. Hum Pathol, 2000, 31(10): 1304-1312.
12. Theelen W, Speel EJ, Herfs M, et al. Increase in viral load, viral integration, and gain of telomerase genes during uterine cervical carcinogenesis can be simultaneously assessed by the HPV 16/18 MLPA-assay. Am J Pathol, 2010, 177(4): 2022-2033.
13. Zhang Y, Wang X, Ma L, et al. Clinical significance of hTERC gene amplification detection by FISH in the screening of cervical lesions. J Huazhong Univ Sci Technolog Med Sci, 2009, 29(3): 368-371.
14. Reesink-Peters N, Helder MN, Wisman GB, et al. Detection of telomerase, its components, and human papillomavirus in cervical scrapings as a tool for triage in women with cervical dysplasia. J Clin Pathol, 2003, 56(1): 31-35.
15. Lanham S, Herbert A, Watt P. HPV detection and measurement of HPV-16, telomerase, and survivin transcripts in colposcopy clinic patients. J Clin Pathol, 2001, 54(4): 304-308.
16. Riethdorf S, Riethdorf L, Schulz G, et al. Relationship between telomerase activation and HPV 16/18 oncogene expression in squamous intraepithelial lesions and squamous cell carcinomas of the uterine cervix. Int J Gynecol Pathol, 2001, 20(2): 177-185.
17. Li Y, Zeng WJ, Ye F, et al. Application of hTERC in thinprep samples with mild cytologic abnormality and HR-HPV positive. Gynecologic Oncology, 2011, 120(1): 73-83.
18. Whiting P, Rutjes AW, Reitsma JB, et al. The development of QUADAS: a tool for the quality assessment of studies of diagnostic accuracy included in systematic reviews. BMC Med Res Method, 2003, 10(3): 25.
19. Lee DK, Kim BC, Kim IY, et al. The human papilloma virus E7 oncoprotein inhibits transforming growth factor-be-tasignaling by blocking binding of the Smad complex toits target sequence. J Biol Chem, 2002, 277(4): 38557-38564.
20. Favre Bonvin A, Reynaud C, Kretz Remy C, et al. Human Papilloma virus type 18 E6 protein binds the cellular PDZ protein TIP-2/GIPC, which is involved in transforming growth factor beta signaling and triggem its degradation by the proteasome. J Virol, 2005, 79: 4229-4237.
21. Mark RP, Trent H, Roger DP, et al. Selection of cervical keratinocytes containing integrated HPV16 associates with episome loss and an endogenous antiviral response. PNAS, 2006, 103(10): 3822-3827.
22. Caraway NP, Khanna A, Dawlett M, et al. Gain of the 3q26 regin in cervicovaginal liquid-based pap preparations is associated with squamous intraepithelial lesions and squamous cell carcinoma. Gynecol Oncol, 2008, 110(1): 37-42.
23. 李靜然, 魏麗惠. 應用雙色間期FISH技術中宮頸脫落細胞取材及制片方法的探討. 中國婦產科臨床雜志, 2007, 8(6): 435-438.
24. Ramsaroop R, Oei P, Ng D, et al. Cervical intraepithelial neoplasia and aneusomy of TERC: assessment of liquid-based cytological preparations. Diagn Cytopathol, 2009, 37(6): 411-415.

《中國循證醫學雜志》

TERC基因對宮頸高級別病變（≥CINⅡ）診斷價值的Meta分析

摘要 全文 圖表 視頻 參考文獻 施引文獻 補充材料

上一篇

下一篇

Format

Content

《中國循證醫學雜志》

TERC基因對宮頸高級別病變（≥CINⅡ）診斷價值的Meta分析

摘要 全文 圖表 視頻 參考文獻 施引文獻 補充材料

上一篇

下一篇

Format

Content

摘要全文圖表視頻參考文獻施引文獻補充材料