酒精干預對大（小）鼠缺血性卒中結局影響的系統評價_《中國循證醫學雜志》

作者：

齊廣偉 ¹ , 鄭佳 ² ,  趙瑞波 ¹

1. 哈爾濱醫科大學病理學教研室（哈爾濱 150081）；2. 哈爾濱醫科大學營養與食品衛生學教研室（哈爾濱 150081）;

關鍵詞：

酒精缺血性卒中腦缺血系統評價 Meta分析動物實驗

DOI：

10.7507/1672-2531.20130035

視頻：

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目的　系統評價酒精干預對大（小）鼠缺血性卒中結局的影響。
方法　計算機檢索PubMed、EMbase、BIOSIS、CNKI、WanFang Data和VIP數據庫中關于酒精干預用于缺血性卒中動物模型的研究，檢索時間截至2012年6月。按納入與排除標準篩選文獻、提取資料和進行方法學質量評價后，采用RevMan 5.1軟件進行Meta分析。
結果　共納入8個研究。Meta分析結果顯示：與對照組相比，酒精干預組對缺血性卒中的影響無統計學意義［MD= –6.98%，95%CI（–20.38%，6.43%），P=0.31］，但低劑量急性酒精干預（≤2 g/kg）可改善缺血性卒中預后［MD= –22.83%，95%CI（–38.77%，–6.89%），P=0.005］，而高濃度慢性酒精干預會加重缺血性卒中腦缺血損傷［MD=24.06%，95%CI（10.54%，37.58%），P=0.000 5］。
結論　低劑量酒精干預對大（小）鼠具有潛在的神經保護作用，高劑量酒精干預則可能加重其腦損傷程度。但應注意，受納入研究發表偏倚等因素的影響，酒精干預對大（小）鼠卒中結局的影響程度可能被高估。

引用本文： 齊廣偉,鄭佳,趙瑞波. 酒精干預對大（小）鼠缺血性卒中結局影響的系統評價. 中國循證醫學雜志, 2013, 13(2): 204-209. doi: 10.7507/1672-2531.20130035 復制

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2.	Macleod MR, O’Collins T, Howells DW, et al. Pooling of animal experimental data reveals influence of study design and publication bias. Stroke, 2004, 35(5):1203-1208.
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7.	Masoero E, Frattini P, Favalli L, et al. Effect of acute alcohol on ischemia-induced glutamate release and brain damage. Alcohol, 2000, 22(3): 173-177.
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9.	Wang F, Wang Y, Geng X, et al. Neuroprotective effect of acute ethanol administration in a rat with transient cerebral ischemia. Stroke, 2012, 43(1): 205-210.
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11.	Zhao H, Mayhan WG, Arrick DM, et al. Alcohol-induced exacerbation of ischemic brain injury: role of NAD(P)H oxidase. Alcohol Clin Exp Res, 2010, 34(11): 1948-1955.
12.	Mandybur TI, Mendenhall CL. The effects of chronic alcoholism on development of ischemic cerebral infarcts following unilateral carotid artery ligation in gerbils. Alcohol Clin Exp Res, 1983, 7(4): 357-361.
13.	Zhao YJ, Yang GY, Domino EF. Acute ethanol effects on focal cerebral ischemia in nonfasted rats. Alcohol Clin Exp Res, 1997, 21(4): 745-748.
14.	Zhao YJ, Yang GY, Ben-Joseph O, et al. Acute ethanol effects on focal cerebral ischemia in fasted rats. Alcohol Clin Exp Res, 1998, 22(3): 717-722.
15.	Qi SH, Liu Y, Wang WW, et al. Neuroprotection of ethanol against cerebral ischemia/reperfusion induced brain injury through GABA receptor activation. Brain Res, 2009, 1276: 151-158.
16.	Qi SH, Liu Y, Hao LY, et al. Neuroprotection of ethanol against ischemia/reperfusion -induced brain injury through decreasing c-Jun N-terminal kinase 3 (JNK3) activation by enhancing GABA release. Neuroscience, 2010, 167(4): 1125-1137.
17.	Zeng X, Asmaro K, Ren C, et al. Acute ethanol treatment reduces blood-brain barrier dysfunction following ischemia/reperfusion injury. Brain Res, 2012, 1437: 127-133.
18.	Sena E, van der Worp HB, Howells D, et al. How can we improve the pre-clinical development of drugs for stroke? Trends Neurosci, 2007, 30(9): 433-439.
19.	Macleod MR, O’Collins T, Horky LL, et al. FK506對實驗性卒中療效的系統評價和Meta分析. 中國循證醫學雜志, 2006, 6(5): 430-434.

1. Patra J, Taylor B, Irving H, et al. Alcohol consumption and the risk of morbidity and mortality for different stroke types–a systematic review and meta-analysis. BMC Public Health, 2010, 10: 258.
2. Macleod MR, O’Collins T, Howells DW, et al. Pooling of animal experimental data reveals influence of study design and publication bias. Stroke, 2004, 35(5):1203-1208.
3. MacDougall NJ, Muir KW. Hyperglycaemia and infarct size in animal models of middle cerebral artery occlusion: systematic review and meta-analysis. J Cereb Blood Flow Metab, 2011, 31(3): 807-818.
4. Crews FT, Steck JC, Chandler LJ, et al. Ethanol, stroke, brain damage, and excitotoxicity. Pharmacol Biochem Behav, 1998, 59(4): 981-991.
5. Zhao H, Mayhan WG, Arrick DM, et al. Dose-related influence of chronic alcohol consumption on cerebral ischemia/reperfusion injury. Alcohol Clin Exp Res, 2011, 35(7): 1265-1269.
6. Phillis JW, Estevez AY, O’Regan MH. Protective effects of the free radical scavengers, dimethyl sulfoxide and ethanol, in cerebral ischemia in gerbils. Neurosci Lett, 1998, 244(2): 109-111.
7. Masoero E, Frattini P, Favalli L, et al. Effect of acute alcohol on ischemia-induced glutamate release and brain damage. Alcohol, 2000, 22(3): 173-177.
8. Strong R, Grotta JC, Aronowski J. Combination of low dose ethanol and caffeine protects brain from damage produced by focal ischemia in rats. Neuropharmacology, 2000, 39(3): 515-522.
9. Wang F, Wang Y, Geng X, et al. Neuroprotective effect of acute ethanol administration in a rat with transient cerebral ischemia. Stroke, 2012, 43(1): 205-210.
10. Wang Q, Sun AY, Simonyi A, et al. Ethanol preconditioning protects against ischemia/reperfusion-induced brain damage: role of NADPH oxidase-derived ROS. Free Radic Biol Med, 2007, 43(7): 1048-1060.
11. Zhao H, Mayhan WG, Arrick DM, et al. Alcohol-induced exacerbation of ischemic brain injury: role of NAD(P)H oxidase. Alcohol Clin Exp Res, 2010, 34(11): 1948-1955.
12. Mandybur TI, Mendenhall CL. The effects of chronic alcoholism on development of ischemic cerebral infarcts following unilateral carotid artery ligation in gerbils. Alcohol Clin Exp Res, 1983, 7(4): 357-361.
13. Zhao YJ, Yang GY, Domino EF. Acute ethanol effects on focal cerebral ischemia in nonfasted rats. Alcohol Clin Exp Res, 1997, 21(4): 745-748.
14. Zhao YJ, Yang GY, Ben-Joseph O, et al. Acute ethanol effects on focal cerebral ischemia in fasted rats. Alcohol Clin Exp Res, 1998, 22(3): 717-722.
15. Qi SH, Liu Y, Wang WW, et al. Neuroprotection of ethanol against cerebral ischemia/reperfusion induced brain injury through GABA receptor activation. Brain Res, 2009, 1276: 151-158.
16. Qi SH, Liu Y, Hao LY, et al. Neuroprotection of ethanol against ischemia/reperfusion -induced brain injury through decreasing c-Jun N-terminal kinase 3 (JNK3) activation by enhancing GABA release. Neuroscience, 2010, 167(4): 1125-1137.
17. Zeng X, Asmaro K, Ren C, et al. Acute ethanol treatment reduces blood-brain barrier dysfunction following ischemia/reperfusion injury. Brain Res, 2012, 1437: 127-133.
18. Sena E, van der Worp HB, Howells D, et al. How can we improve the pre-clinical development of drugs for stroke? Trends Neurosci, 2007, 30(9): 433-439.
19. Macleod MR, O’Collins T, Horky LL, et al. FK506對實驗性卒中療效的系統評價和Meta分析. 中國循證醫學雜志, 2006, 6(5): 430-434.

《中國循證醫學雜志》

酒精干預對大（小）鼠缺血性卒中結局影響的系統評價

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《中國循證醫學雜志》

酒精干預對大（小）鼠缺血性卒中結局影響的系統評價

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