肝素預防新生兒經外周中心靜脈置管相關感染的回顧性研究_《中國循證醫學雜志》

作者：

唐軍 ,  熊英

四川大學華西第二醫院兒科（成都 610041）;

關鍵詞：

經外周導入中心靜脈置管導管相關感染肝素全合一靜脈營養液新生兒回顧性分析

DOI：

10.7507/1672-2531.20100538

視頻：

導出 下載 收藏 掃碼 引用

摘要 全文 圖表 視頻 參考文獻 施引文獻 補充材料

目的 ?觀察全合一靜脈營養液中加入小劑量肝素持續輸注對新生兒經外周導入中心靜脈置管（PICC）相關感染的預防作用。
方法 ?將我院新生兒重癥監護病房2007.5～2008.12 行PICC置管的103例患者分為兩組：肝素組（n=63）在全合一營養液中加入肝素0.5 U/mL，對照組（n=40）不加肝素，回顧性分析比較兩組導管相關性敗血癥（CRI）發生情況。
結果 ?肝素組發生導管堵塞4例（6.3%），導管內細菌定植1例（1.58%），導管相關血流感染0例；對照組發生導管堵塞8例（20%），導管內細菌定植7例（17.5%），導管相關血流感染5例（12.5%），兩組比較其差異均有統計學意義（P lt;0.05）。
結論 ?靜脈營養液中加入0.5 U/mL的肝素可減少PICC堵管，預防導管相關感染發生。

引用本文： 唐軍,熊英. 肝素預防新生兒經外周中心靜脈置管相關感染的回顧性研究. 中國循證醫學雜志, 2010, 10(9): 1023-1026. doi: 10.7507/1672-2531.20100538 復制

1.	Durand M, Ramanathan R, Martinelli B, et al. Prospective evaluation of percutaneous central venous Silastic catheters in newborn infants with birth weights of 510 to 3,920 grams. Pediatrics, 1986, 78: 245-250.
2.	Klein JF, Shahrivar F. Use of percutaneous Silastic central venous catheters in neonates and the management of infectious complications. Am J Perinatol, 1992, 9: 261-264.
3.	Nakamura KT, Sato Y, Erenberg A. Evaluation of a percutaneously placed 27-gauge central venous catheter in neonates weighing less than 1200 grams. J Parenter Enteral Nutr, 1990, 14: 295-299.
4.	Salzman MB, Isenberg HD, Shapiro JF, et al. A prospective study of the catheter hub as the portal of entry for microorganisms causing catheter-related sepsis in neonates. J Infect Dis, 1993, 167: 487-490.
5.	Chien LY, Macnab Y, Aziz K, et al. Variations in central venous catheter-related infection risks among Canadian neonatal intensive care units. Pediatr Infect Dis J, 2002, 21: 505-511.
6.	Cardella JF, Cardella K, Bacci N, et al. Cumulative experience with 1,273 peripherally inserted central catheters at a single institution. J Vasc Interv Radiol, 1996, 7: 5-13.
7.	Brismar B, Hardstedt C, Jacobson S, et al. Reduction of catheter-associated thrombosis in parenteral nutrition by intravenous heparin therapy. Arch Surg, 1982, 117: 1196-1199.
8.	Hoshal VL Jr, Ause RG, Hoskins PA. Fibrin sleeve formation on indwelling subclavian central venous catheters. Arch Surg, 1971, 102: 253-258.
9.	Krate-Jacobs B, Sivit CJ, Mejia R, et al. Catheter-related thrombosis in critically ill children: comparison of catheters with and without heparin bonding. J Pediatr, 1995, 126: 50-54.
10.	Spaford PS, Sinkin RA, Cox C, et al. Prevention of central venous catheter-related coagulase negative Staphylococcus sepsis in neonates. J Pediatr, 1994, 125: 260-263.
11.	Maki DG, Stolz SM, Wheeler S, et al. Prevention of central venous catheter-related bloodstream infection by use of an antiseptic-impregnated catheter: a randomized, controlled trial. Ann Intern Med, 1997, 127: 257-266.
12.	Maki DG, Stolz SM, Wheeler S, et al. Prevention of central venous catheter-related bloodstream infection by use of an antiseptic-impregnated catheter: a randomized, controlled trial. Ann Intern Med, 1997, 127: 257-266.
13.	Salzman MB, Rubin LG. Intravenous catheter - related infections. Adv Pediatr Infect Dis, 1995, 10: 337-368.
14.	Salzman MB, Rubin LG. Intravenous catheter - related infections. Adv Pediatr Infect Dis, 1995, 10: 337-368.
15.	Safdar N, Maki DG. Risk of catheter related bloodstream infection with peripherally inserted central venous catheters used in hospitalized patients. Chest, 2005, 128(2): 489-495.
16.	O’Keefe SJ, Bean E, Symmonds K, et al. Clinical evaluation of a ‘3-in-1’ intravenous nutrient solution. S Afr Med J, 1985, 68: 82-86.
17.	Adam B, Baillie GS, Douglas LJ. Mixed species bioilms of Candida albicans and Staphylococcus epidemidis. J Med Microbiol, 2002, 51: 344-349.

1. Durand M, Ramanathan R, Martinelli B, et al. Prospective evaluation of percutaneous central venous Silastic catheters in newborn infants with birth weights of 510 to 3,920 grams. Pediatrics, 1986, 78: 245-250.
2. Klein JF, Shahrivar F. Use of percutaneous Silastic central venous catheters in neonates and the management of infectious complications. Am J Perinatol, 1992, 9: 261-264.
3. Nakamura KT, Sato Y, Erenberg A. Evaluation of a percutaneously placed 27-gauge central venous catheter in neonates weighing less than 1200 grams. J Parenter Enteral Nutr, 1990, 14: 295-299.
4. Salzman MB, Isenberg HD, Shapiro JF, et al. A prospective study of the catheter hub as the portal of entry for microorganisms causing catheter-related sepsis in neonates. J Infect Dis, 1993, 167: 487-490.
5. Chien LY, Macnab Y, Aziz K, et al. Variations in central venous catheter-related infection risks among Canadian neonatal intensive care units. Pediatr Infect Dis J, 2002, 21: 505-511.
6. Cardella JF, Cardella K, Bacci N, et al. Cumulative experience with 1,273 peripherally inserted central catheters at a single institution. J Vasc Interv Radiol, 1996, 7: 5-13.
7. Brismar B, Hardstedt C, Jacobson S, et al. Reduction of catheter-associated thrombosis in parenteral nutrition by intravenous heparin therapy. Arch Surg, 1982, 117: 1196-1199.
8. Hoshal VL Jr, Ause RG, Hoskins PA. Fibrin sleeve formation on indwelling subclavian central venous catheters. Arch Surg, 1971, 102: 253-258.
9. Krate-Jacobs B, Sivit CJ, Mejia R, et al. Catheter-related thrombosis in critically ill children: comparison of catheters with and without heparin bonding. J Pediatr, 1995, 126: 50-54.
10. Spaford PS, Sinkin RA, Cox C, et al. Prevention of central venous catheter-related coagulase negative Staphylococcus sepsis in neonates. J Pediatr, 1994, 125: 260-263.
11. Maki DG, Stolz SM, Wheeler S, et al. Prevention of central venous catheter-related bloodstream infection by use of an antiseptic-impregnated catheter: a randomized, controlled trial. Ann Intern Med, 1997, 127: 257-266.
12. Maki DG, Stolz SM, Wheeler S, et al. Prevention of central venous catheter-related bloodstream infection by use of an antiseptic-impregnated catheter: a randomized, controlled trial. Ann Intern Med, 1997, 127: 257-266.
13. Salzman MB, Rubin LG. Intravenous catheter - related infections. Adv Pediatr Infect Dis, 1995, 10: 337-368.
14. Salzman MB, Rubin LG. Intravenous catheter - related infections. Adv Pediatr Infect Dis, 1995, 10: 337-368.
15. Safdar N, Maki DG. Risk of catheter related bloodstream infection with peripherally inserted central venous catheters used in hospitalized patients. Chest, 2005, 128(2): 489-495.
16. O’Keefe SJ, Bean E, Symmonds K, et al. Clinical evaluation of a ‘3-in-1’ intravenous nutrient solution. S Afr Med J, 1985, 68: 82-86.
17. Adam B, Baillie GS, Douglas LJ. Mixed species bioilms of Candida albicans and Staphylococcus epidemidis. J Med Microbiol, 2002, 51: 344-349.

《中國循證醫學雜志》

肝素預防新生兒經外周中心靜脈置管相關感染的回顧性研究

摘要 全文 圖表 視頻 參考文獻 施引文獻 補充材料

上一篇

下一篇

Format

Content

《中國循證醫學雜志》

肝素預防新生兒經外周中心靜脈置管相關感染的回顧性研究

摘要 全文 圖表 視頻 參考文獻 施引文獻 補充材料

上一篇

下一篇

Format

Content

摘要全文圖表視頻參考文獻施引文獻補充材料