Meta分析中發表偏倚的Begg’s檢驗、Egger’s檢驗及Macaskill’s檢驗的SAS程序實現_《中國循證醫學雜志》

作者：

鄭輝烈 ^1,2 , 王忠旭 ³ ,  王增珍 ¹

1. 華中科技大學同濟醫學院公共衛生學院流行病與衛生統計系（武漢?430030）；2. 南昌大學醫學院公共衛生學院流行病與衛生統計系（南昌?330006）；3. 中國疾病預防控制中心（北京?100050）;

關鍵詞：

Meta分析發表偏倚 Begg’s 檢驗 Egger’s 檢驗 Macaskill’s 檢驗

DOI：

10.7507/1672-2531.20090160

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Meta分析的結論易受各種偏倚的影響，“發表偏倚”是其中重要的偏倚之一。所以，評價所納入的研究是否存在發表偏倚是Meta分析的一項重要的前期準備工作。Begg’s檢驗、Egger’s檢驗和Macaskill’s檢驗是常見的用于定量評價Meta分析“發表偏倚”的方法，為了便于這些檢驗方法的應用，本文編寫了基于SAS系統的這三個檢驗的程序，經實例數據分析，其運行結果與Stata軟件完全相同。為研究人員提供了同時實現這三個檢驗的有效途徑。

引用本文： 鄭輝烈,王忠旭,王增珍. Meta分析中發表偏倚的Begg’s檢驗、Egger’s檢驗及Macaskill’s檢驗的SAS程序實現. 中國循證醫學雜志, 2009, 09(8): 910-916. doi: 10.7507/1672-2531.20090160 復制

1.	Begg CB, Berlin JA. Publication bias: A problem in interpreting medical data. Journal of the Royal Statistical Society, Series A, 1988, 151(3): 419-463.
2.	Dickersin K, Scherer R, Lefebvre C. Identifying relevant studies for systematic reviews. BMJ, 1994, 309(6964): 1286-1291.
3.	Dickersin K. How important is publication bias? A synthesis of available data. AIDS Education and Prevention, 1997, 9(1 Suppl): 15-21.
4.	Begg CB. Publication bias. In The Handbook of Research Synthesis, Cooper H, Hedges LV (eds). Russell Sage Foundation: New York, 1994, Chapter 25.
5.	Light RJ, Pillemer DB. Summing Up: The Science of Reviewing Research. Harvard University Press: Cambridge MA, 1984.
6.	Greenland S. Invited commentary: a critical look at some popular meta-analytic methods. Am J Epidemiol, 1994, 140: 290-296.
7.	Begg CB, Mazumdar M. Operating characteristics of a rank correlation test for publication bias. Biometrics, 1994, 50: 1088-1101.
8.	Egger M, Smith GD, Schneider M, et al. Bias in meta-analysis detected by a simple, graphical test. BMJ, 1997, 315: 629-634.
9.	Macaskill P, Walter SD, Irwig L. A comparison of methods to detect publication bias in meta-analysis. Stat Med, 2001, 20: 641-654.
10.	Kendall MG. A New Measure of Rank Correlation. Biometrika, 1938, 30(1-2): 81-93.
11.	Shi XQ, Zhou SH, Wang ZX, et al. CYP1A1 and GSTM1 polymorphisms and lung cancer risk in Chinese populations: A meta-analysis. Lung Cancer, 2008, 59: 155-163.
12.	Zhuo XG, Melby MK, Watanabe S. Soy Isoflavone Intake Lowers Serum LDL Cholesterol: A Meta-Analysis of 8 Randomized Controlled Trials in Humans. J Nutr, 2004, 134: 2395-2400.
13.	Easterbrook PJ, Berlin JA, Gopalan R, et al. Publication bias in clinical research. Lancet, 1991, 337: 867-872.
14.	Sutton AJ, Duval SJ, Tweedie RL, et al. Empirical assessment of effect of publication bias on metaanalyses. BMJ, 2000, 320: 1574-1577.
15.	Macaskill P, Walter SD, Irwig L. A comparison of methods to detect publication bias in meta-analysis. Stat Med, 2001, 20: 641-654.
16.	Hayashino Y, Noguchi Y, Fukui T. Systematic evaluation and comparison of statistical tests for publication bias. Journal of Epidemiologym, 2005, 15(6): 235-243.

1. Begg CB, Berlin JA. Publication bias: A problem in interpreting medical data. Journal of the Royal Statistical Society, Series A, 1988, 151(3): 419-463.
2. Dickersin K, Scherer R, Lefebvre C. Identifying relevant studies for systematic reviews. BMJ, 1994, 309(6964): 1286-1291.
3. Dickersin K. How important is publication bias? A synthesis of available data. AIDS Education and Prevention, 1997, 9(1 Suppl): 15-21.
4. Begg CB. Publication bias. In The Handbook of Research Synthesis, Cooper H, Hedges LV (eds). Russell Sage Foundation: New York, 1994, Chapter 25.
5. Light RJ, Pillemer DB. Summing Up: The Science of Reviewing Research. Harvard University Press: Cambridge MA, 1984.
6. Greenland S. Invited commentary: a critical look at some popular meta-analytic methods. Am J Epidemiol, 1994, 140: 290-296.
7. Begg CB, Mazumdar M. Operating characteristics of a rank correlation test for publication bias. Biometrics, 1994, 50: 1088-1101.
8. Egger M, Smith GD, Schneider M, et al. Bias in meta-analysis detected by a simple, graphical test. BMJ, 1997, 315: 629-634.
9. Macaskill P, Walter SD, Irwig L. A comparison of methods to detect publication bias in meta-analysis. Stat Med, 2001, 20: 641-654.
10. Kendall MG. A New Measure of Rank Correlation. Biometrika, 1938, 30(1-2): 81-93.
11. Shi XQ, Zhou SH, Wang ZX, et al. CYP1A1 and GSTM1 polymorphisms and lung cancer risk in Chinese populations: A meta-analysis. Lung Cancer, 2008, 59: 155-163.
12. Zhuo XG, Melby MK, Watanabe S. Soy Isoflavone Intake Lowers Serum LDL Cholesterol: A Meta-Analysis of 8 Randomized Controlled Trials in Humans. J Nutr, 2004, 134: 2395-2400.
13. Easterbrook PJ, Berlin JA, Gopalan R, et al. Publication bias in clinical research. Lancet, 1991, 337: 867-872.
14. Sutton AJ, Duval SJ, Tweedie RL, et al. Empirical assessment of effect of publication bias on metaanalyses. BMJ, 2000, 320: 1574-1577.
15. Macaskill P, Walter SD, Irwig L. A comparison of methods to detect publication bias in meta-analysis. Stat Med, 2001, 20: 641-654.
16. Hayashino Y, Noguchi Y, Fukui T. Systematic evaluation and comparison of statistical tests for publication bias. Journal of Epidemiologym, 2005, 15(6): 235-243.

《中國循證醫學雜志》

Meta分析中發表偏倚的Begg’s檢驗、Egger’s檢驗及Macaskill’s檢驗的SAS程序實現

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《中國循證醫學雜志》

Meta分析中發表偏倚的Begg’s檢驗、Egger’s檢驗及Macaskill’s檢驗的SAS程序實現

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