硫酸鎂治療重度哮喘的臨床證據（附報告一例）_《中國循證醫學雜志》

作者：

付娟娟 , 毛兵

四川大學華西臨床醫學院中西醫結合科（成都 610041）;

關鍵詞：

硫酸鎂哮喘循證治療系統評價

DOI：

10.7507/1672-2531.20080243

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目的　對硫酸鎂治療重度哮喘的系統評價進行再評價。
方法　計算機檢索Cochrane圖書館（2008 年第2 期）、ACP Journal Club（1991^2008.6）、MEDLINE（1990^2008.6）、中國期刊全文數據庫（1979^2008.6）、中文科技期刊全文數據庫（VIP）（1980^2008.6）和中國生物醫學文獻數據庫（CBM）（1980^2008.6），查找有關硫酸鎂治療哮喘的系統評價，并進行再評價，將證據應用于臨床實踐。
結果　共納入9 篇系統評價，平均包含了QUOROM (thequality of reporting of Meta-analyses) 標準條目中的14.1±2.9 項，質量較高。現有證據表明靜脈滴注使用硫酸鎂可改善重度哮喘急性發作患者的肺功能，減少入院率，且無嚴重不良反應；但無足夠證據證明吸入和口服硫酸鎂對哮喘的治療作用。我們將上述證據應用于臨床，對1 例重度哮喘患者行靜脈滴注硫酸鎂治療，該患者哮喘癥狀控制良好，未發生不良反應。
結論　靜脈使用硫酸鎂可改善重度哮喘患者的肺功能、降低入院率，安全、有效，應更多地應用于重度哮喘患者的臨床治療。

引用本文： 付娟娟,毛兵. 硫酸鎂治療重度哮喘的臨床證據（附報告一例）. 中國循證醫學雜志, 2008, 08(12): 1126-1129. doi: 10.7507/1672-2531.20080243 復制

1.	CHINA, Global Strategy for Asthma Management and Prevention: Revised 2006. In: htpp//www.ginasthma.org.
2.	GINA, Global Strategy for Asthma Management and Prevention:.
3.	The Evidence-Based Medicine Working Group. Users’ Guides to the Medical Literature: A Manual for Evidence-Based Clinical Practice. Chicago: AMA Press. 2002.
4.	Phillips B, Ball C, Sackett D, et al. Levels of evidence and grades of recommendation. Available from:URL:http://www.cebm.net/.
5.	Rodrigo G, Rodrigo C, Burschtin O, et al. Efficacy of Magnesium Sulfate in Acute Adult Asthma: A Meta-Analysis of Randomized Trials. Am J Emerg Med, 2000, 18(2): 216-221.
6.	Rowe BH, Bretzlaff JA, Bourdon C, et al. Intravenous Magnesium Sulfate Treatment for Acute Asthma in the Emergency Department: A Systematic Review of the Literature. Ann Emerg Med, 2000, 36(3): 181-190.
7.	Rowe BH, Bretzlaff JA, Bourdon C, et al. Magnesium sulfate for treating exacerbations of acute asthma in the emergency department. Cochrane Database of Systematic Reviews 2000, Issue 1. Art. No.: CD001490.
8.	Cheuk DKL, Chau TCH，Lee SL, et al. A meta-analysis on intravenous magnesium sulphate fortreating acute asthma. Arch Dis Child, 2005, 90: 74-77.
9.	Rowe BH, Camargo CA. The role of magnesium sulfate in the acute and chronic management of asthma. Cur Opin Pulm Med, 2008, 14: 70.
10.	Blitz M, Blitz S, Hughes R, et al. Aerosolized Magnesium Sulfate for Acute Asthma: A Systematic Review. Chest, 2005, 128: 337-344.
11.	Blitz M, Blitz S, Beasely R, et al. Inhaled magnesium sulfate in the treatment of acute asthma. Cochrane Database of Systematic Reviews 2005, Issue 4. Art. No.: CD003898.
12.	魯曉勇, 周建英. 以不同溶媒霧化吸入沙丁胺醇對哮喘急性發作治療作用的Meta分析.浙江大學學報 (醫學版), 2006, 35(3): 336-341.
13.	Villeneuve EJ, Zed PJ. Nebulized Magnesium Sulfate in the Management of Acute Exacerbations of Asthma. Ann Pharmacother, 2006, 40: 1118-1124.
14.	Moher D, Cook DJ, Eastwood S, et al. Improving the quality of reports of meta-analyses of randomised controlled trials: the QUOROM statement. Lancet, 1999, 354: 1896-1900.

1. CHINA, Global Strategy for Asthma Management and Prevention: Revised 2006. In: htpp//www.ginasthma.org.
2. GINA, Global Strategy for Asthma Management and Prevention:.
3. The Evidence-Based Medicine Working Group. Users’ Guides to the Medical Literature: A Manual for Evidence-Based Clinical Practice. Chicago: AMA Press. 2002.
4. Phillips B, Ball C, Sackett D, et al. Levels of evidence and grades of recommendation. Available from:URL:http://www.cebm.net/.
5. Rodrigo G, Rodrigo C, Burschtin O, et al. Efficacy of Magnesium Sulfate in Acute Adult Asthma: A Meta-Analysis of Randomized Trials. Am J Emerg Med, 2000, 18(2): 216-221.
6. Rowe BH, Bretzlaff JA, Bourdon C, et al. Intravenous Magnesium Sulfate Treatment for Acute Asthma in the Emergency Department: A Systematic Review of the Literature. Ann Emerg Med, 2000, 36(3): 181-190.
7. Rowe BH, Bretzlaff JA, Bourdon C, et al. Magnesium sulfate for treating exacerbations of acute asthma in the emergency department. Cochrane Database of Systematic Reviews 2000, Issue 1. Art. No.: CD001490.
8. Cheuk DKL, Chau TCH，Lee SL, et al. A meta-analysis on intravenous magnesium sulphate fortreating acute asthma. Arch Dis Child, 2005, 90: 74-77.
9. Rowe BH, Camargo CA. The role of magnesium sulfate in the acute and chronic management of asthma. Cur Opin Pulm Med, 2008, 14: 70.
10. Blitz M, Blitz S, Hughes R, et al. Aerosolized Magnesium Sulfate for Acute Asthma: A Systematic Review. Chest, 2005, 128: 337-344.
11. Blitz M, Blitz S, Beasely R, et al. Inhaled magnesium sulfate in the treatment of acute asthma. Cochrane Database of Systematic Reviews 2005, Issue 4. Art. No.: CD003898.
12. 魯曉勇, 周建英. 以不同溶媒霧化吸入沙丁胺醇對哮喘急性發作治療作用的Meta分析.浙江大學學報 (醫學版), 2006, 35(3): 336-341.
13. Villeneuve EJ, Zed PJ. Nebulized Magnesium Sulfate in the Management of Acute Exacerbations of Asthma. Ann Pharmacother, 2006, 40: 1118-1124.
14. Moher D, Cook DJ, Eastwood S, et al. Improving the quality of reports of meta-analyses of randomised controlled trials: the QUOROM statement. Lancet, 1999, 354: 1896-1900.

《中國循證醫學雜志》

硫酸鎂治療重度哮喘的臨床證據（附報告一例）

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《中國循證醫學雜志》

硫酸鎂治療重度哮喘的臨床證據（附報告一例）

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