慢性阻塞性肺病合并認知障礙的研究進展_Chinese Journal of Respiratory and Critical Care Medicine

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關婭茹 ¹ ,  李龍 ²

1. ;
2. ;

Corresponding?author：

李龍, Email: llqqdbd@163.com

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DOI：

10.7507/1671-6205.202509042

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Citation： 關婭茹, 李龍. 慢性阻塞性肺病合并認知障礙的研究進展. Chinese Journal of Respiratory and Critical Care Medicine, 2026, 25(8): 603-607. doi: 10.7507/1671-6205.202509042 Copy

1.	Boers E, Barrett M, Su J G, et al. Global Burden of Chronic Obstructive Pulmonary Disease Through 2050[J]. JAMA Netw Open, 2023, 6(12): e2346598.
2.	Wu X, Huang K, Jiang T, et al. Risk factors of cognitive frailty in elderly chronic obstructive pulmonary disease patients and its implication for death: a cohort study[J]. Psychogeriatrics, 2024, 24(2): 295-302.
3.	Simargi Y, Mansyur M, Turana Y, et al. Risk of developing cognitive impairment on patients with chronic obstructive pulmonary disease: A systematic review[J]. Medicine (Baltimore), 2022, 101(25): e29235.
4.	Han Y, Jia J, Li X, et al. Expert Consensus on the Care and Management of Patients with Cognitive Impairment in China[J]. Neurosci Bull, 2020, 36(3): 307-320.
5.	Brunette A M, Warner K, Holm K E, et al. Daily Activities: The Impact of COPD and Cognitive Dysfunction[J]. Arch Clin Neuropsychol, 2021, 36(5): acaa090 767 779-767.
6.	Chen Z, Shang Y, Ou Y, et al. Obstructive Sleep Apnea Plasma-Derived Exosomes Mediate Cognitive Impairment Through Hippocampal Neuronal Cell Pyroptosis[J]. Am J Geriatr Psychiatry, 2024, 32(8): 922-939.
7.	Huang X, Hussain B, Chang J. Peripheral inflammation and blood-brain barrier disruption: effects and mechanisms[J]. CNS Neurosci Ther, 2021, 27(1): 36-47.
8.	Yu X, Xiao H, Liu Y, et al. The Lung-Brain Axis in Chronic Obstructive Pulmonary Disease-Associated Neurocognitive Dysfunction: Mechanistic Insights and Potential Therapeutic Options[J]. Int J Biol Sci, 2025, 21(8): 3461-3477.
9.	He J K, Han X Y, Tan Y S, et al. Aberrant brain functional network in COPD patients with cognitive impairment: clinical manifestations, mechanisms and therapeutic strategies[J]. J Neuroinflammation, 2025, 23(1): 30.
10.	Fang Y T, Lin Y T, Tseng W L, et al. Neuroimmunomodulation of vagus nerve stimulation and the therapeutic implications[J]. Front Aging Neurosci, 2023, 15: 1173987.
11.	Polverino F, Sin D D. Type 2 airway inflammation in COPD[J]. Eur Respir J, 2024, 63(5).
12.	Cheng Y, Hu G, Deng L, et al. Therapeutic role of gut microbiota in lung injury-related cognitive impairment[J]. Front Nutr, 2024, 11: 1521214.
13.	Tan J Y, Tang Y C, Huang J. Gut Microbiota and Lung Injury[J]. Adv Exp Med Biol, 2020, 1238: 55-72.
14.	Yuchen Z, Du M R, Zhang Q Y, et al. Armillariella tabescens-derived polysaccharides alleviated D-Gal-induced neuroinflammation and cognitive injury through enterocerebral axis and activation of keap-1/Nrf2 pathway[J]. Int J Biol Macromol, 2024, 273(Pt 1): 133035.
15.	Jia-Kai H, Yun-Sheng T, Xin-Yu H, et al. Brain structural changes in COPD patients with cognitive impairment[J]. J Neurol, 2026, 273(1): 53.
16.	Liang J, Yu Q, Chen L, et al. Gray matter and cognitive alteration related to chronic obstructive pulmonary disease patients: combining ALE meta-analysis and MACM analysis[J]. Brain Imaging Behav, 2025, 19(1): 204-217.
17.	Spilling C A, Jones P W, Dodd J W, et al. Disruption of white matter connectivity in chronic obstructive pulmonary disease[J]. PLoS One, 2019, 14(10): e0223297.
18.	Han K I, Yeo Y, Jo H J, et al. Abnormal Brain Functional Connectivity in Patients with Chronic Obstructive Pulmonary Disease and Correlations with Clinical and Cognitive Parameters[J]. Int J Chron Obstruct Pulmon Dis, 2025, 20: 971-985.
19.	Jeong S M, Park J, Han K, et al. Association of Changes in Smoking Intensity With Risk of Dementia in Korea[J]. JAMA Netw Open, 2023, 6(1): e2251506.
20.	Dobric A, De Luca S N, Spencer S J, et al. Novel pharmacological strategies to treat cognitive dysfunction in chronic obstructive pulmonary disease[J]. Pharmacol Ther, 2022, 233: 108017.
21.	Zailani H, Satyanarayanan S K, Liao W C, et al. Omega-3 Polyunsaturated Fatty Acids in Managing Comorbid Mood Disorders in Chronic Obstructive Pulmonary Disease (COPD): A Review[J]. J Clin Med, 2023, 12(7).
22.	Wen X H, Li Y, Han D, et al. The relationship between cognitive function and arterial partial pressure O2 in patients with COPD: A meta-analysis[J]. Medicine (Baltimore), 2018, 97(4): e9599.
23.	Siraj R A. Comorbid Cognitive Impairment in Chronic Obstructive Pulmonary Disease (COPD): Current Understanding, Risk Factors, Implications for Clinical Practice, and Suggested Interventions[J]. Medicina (Kaunas), 2023, 59(4).
24.	Wang Q, Zhong X, Gao P, et al. Association and interaction of blood homocysteine and p-tau217 levels with temporal cortical thinning and cognitive impairment in Alzheimer's disease[J]. Alzheimers Dement, 2025, 21(7): e70465.
25.	Zhou S, Chen J, Cheng L, et al. Age-Dependent Association Between Elevated Homocysteine and Cognitive Impairment in a Post-stroke Population: A Prospective Study[J]. Front Nutr, 2021, 8: 691837.
26.	Liu N, Wang H, Han B, et al. Correlation analysis between cerebral microangiopathy and autonomic nervous dysfunction[J]. Brain Behav, 2024, 14(2): e3391.
27.	Song H, Bharadwaj P K, Raichlen D A, et al. Association of homocysteine-related subcortical brain atrophy with white matter lesion volume and cognition in healthy aging[J]. Neurobiol Aging, 2023, 121: 129-138.
28.	Luo J, Yang W, Liu Y, et al. Construction and evaluation of nomogram for risk prediction of cognitive impairment in chronic obstructive pulmonary disease comorbidity[J]. BMC Psychol, 2025, 13(1): 273.
29.	Sun Y, Koyama Y, Shimada S. Inflammation From Peripheral Organs to the Brain: How Does Systemic Inflammation Cause Neuroinflammation?[J]. Front Aging Neurosci, 2022, 14: 903455.
30.	Figat M, Wi?niewska A, Plichta J, et al. Potential association between obstructive lung diseases and cognitive decline[J]. Front Immunol, 2024, 15: 1363373.
31.	Van Zeller M, Mcnicholas W T. Sleep disordered breathing: OSA-COPD overlap[J]. Expert Rev Respir Med, 2024, 18(6): 369-379.
32.	Wang Y, Li B, Li P, et al. Severe obstructive sleep apnea in patients with chronic obstructive pulmonary disease is associated with an increased prevalence of mild cognitive impairment[J]. Sleep Med, 2020, 75: 522-530.
33.	Hansen K K, L?kke A, Jensen H I, et al. Examining the impact of obstructive sleep apnea on cognitive function in severe COPD[J]. Sleep Breath, 2024, 29(1): 59.
34.	Panagioti M, Scott C, Blakemore A, et al. Overview of the prevalence, impact, and management of depression and anxiety in chronic obstructive pulmonary disease[J]. Int J Chron Obstruct Pulmon Dis, 2014, 9: 1289-306.
35.	Shea S, Palka J M, Kulikova A, et al. Relationship between chronic obstructive pulmonary disease and cognition in an aging population[J]. J Psychosom Res, 2022, 161: 111000.
36.	Fan Y, Zhang C, Fan Z, et al. Development and validation of a nomogram for predicting the risk of cognitive impairment among chronic obstructive pulmonary diseases[J]. Ann Med, 2025, 57(1): 2528448.
37.	Rochester C L, Holland A E. Pulmonary Rehabilitation and Improved Survival for Patients With COPD[J]. Jama, 2020, 323(18): 1783-1785.
38.	Ding K, Song F, Sun W, et al. Impact of exercise training on cognitive function in patients with COPD: a systematic review and meta-analysis of randomised controlled trials[J]. Eur Respir Rev, 2025, 34(175).
39.	Song F, Ding K, Sun M, et al. Effect of 12-week head-down strong abdominal breathing on cognitive function in patients with stable chronic obstructive pulmonary disease: a single-centre randomised controlled trial protocol[J]. Trials, 2024, 25(1): 351.
40.	Han M, Wu H, Xu H, et al. The relationship between social isolation and cognitive function in older patients with chronic obstructive pulmonary disease: a latent profile analysis[J]. BMC Geriatr, 2025, 25(1): 561.
41.	Verduri A, O'neill M, Ghinassi F, et al. The use of the MoCA in cognitive impairment for older patients with Chronic Obstructive Pulmonary disease: A preliminary study[J]. Sci Prog, 2025, 108(3): 368504251347114.
42.	Lv R, Zhao Y, Wang X, et al. GLP-1 analogue liraglutide attenuates CIH-induced cognitive deficits by inhibiting oxidative stress, neuroinflammation, and apoptosis via the Nrf2/HO-1 and MAPK/NF-κB signaling pathways[J]. Int Immunopharmacol, 2024, 142(Pt B): 113222.
43.	Momeni Safarabadi A, Gholami M, Kordestani-Moghadam P, et al. The effect of rosemary hydroalcoholic extract on cognitive function and activities of daily living of patients with chronic obstructive pulmonary disease (COPD): A clinical trial[J]. Explore (NY), 2024, 20(3): 362-370.
44.	Zailani H, Satyanarayanan S K, Liao W C, et al. Roles of Omega-3 Polyunsaturated Fatty Acids in Managing Cognitive Impairment in Chronic Obstructive Pulmonary Disease: A Review[J]. Nutrients, 2023, 15(20).
45.	Zhang D W, Yang M M, Zhou M X, et al. Sestrin2 alleviates cognitive impairment via inhibiting hippocampus ferroptosis in cigarette smoke-induced chronic obstructive pulmonary disease[J]. Redox Biol, 2025, 85: 103673.
46.	Lu K, Qu Y, Shi R, et al. Decoding COPD-related cognitive impairment: The protective potential of YTHDF1[J]. Cell Signal, 2026, 139: 112311.

1. Boers E, Barrett M, Su J G, et al. Global Burden of Chronic Obstructive Pulmonary Disease Through 2050[J]. JAMA Netw Open, 2023, 6(12): e2346598.
2. Wu X, Huang K, Jiang T, et al. Risk factors of cognitive frailty in elderly chronic obstructive pulmonary disease patients and its implication for death: a cohort study[J]. Psychogeriatrics, 2024, 24(2): 295-302.
3. Simargi Y, Mansyur M, Turana Y, et al. Risk of developing cognitive impairment on patients with chronic obstructive pulmonary disease: A systematic review[J]. Medicine (Baltimore), 2022, 101(25): e29235.
4. Han Y, Jia J, Li X, et al. Expert Consensus on the Care and Management of Patients with Cognitive Impairment in China[J]. Neurosci Bull, 2020, 36(3): 307-320.
5. Brunette A M, Warner K, Holm K E, et al. Daily Activities: The Impact of COPD and Cognitive Dysfunction[J]. Arch Clin Neuropsychol, 2021, 36(5): acaa090 767 779-767.
6. Chen Z, Shang Y, Ou Y, et al. Obstructive Sleep Apnea Plasma-Derived Exosomes Mediate Cognitive Impairment Through Hippocampal Neuronal Cell Pyroptosis[J]. Am J Geriatr Psychiatry, 2024, 32(8): 922-939.
7. Huang X, Hussain B, Chang J. Peripheral inflammation and blood-brain barrier disruption: effects and mechanisms[J]. CNS Neurosci Ther, 2021, 27(1): 36-47.
8. Yu X, Xiao H, Liu Y, et al. The Lung-Brain Axis in Chronic Obstructive Pulmonary Disease-Associated Neurocognitive Dysfunction: Mechanistic Insights and Potential Therapeutic Options[J]. Int J Biol Sci, 2025, 21(8): 3461-3477.
9. He J K, Han X Y, Tan Y S, et al. Aberrant brain functional network in COPD patients with cognitive impairment: clinical manifestations, mechanisms and therapeutic strategies[J]. J Neuroinflammation, 2025, 23(1): 30.
10. Fang Y T, Lin Y T, Tseng W L, et al. Neuroimmunomodulation of vagus nerve stimulation and the therapeutic implications[J]. Front Aging Neurosci, 2023, 15: 1173987.
11. Polverino F, Sin D D. Type 2 airway inflammation in COPD[J]. Eur Respir J, 2024, 63(5).
12. Cheng Y, Hu G, Deng L, et al. Therapeutic role of gut microbiota in lung injury-related cognitive impairment[J]. Front Nutr, 2024, 11: 1521214.
13. Tan J Y, Tang Y C, Huang J. Gut Microbiota and Lung Injury[J]. Adv Exp Med Biol, 2020, 1238: 55-72.
14. Yuchen Z, Du M R, Zhang Q Y, et al. Armillariella tabescens-derived polysaccharides alleviated D-Gal-induced neuroinflammation and cognitive injury through enterocerebral axis and activation of keap-1/Nrf2 pathway[J]. Int J Biol Macromol, 2024, 273(Pt 1): 133035.
15. Jia-Kai H, Yun-Sheng T, Xin-Yu H, et al. Brain structural changes in COPD patients with cognitive impairment[J]. J Neurol, 2026, 273(1): 53.
16. Liang J, Yu Q, Chen L, et al. Gray matter and cognitive alteration related to chronic obstructive pulmonary disease patients: combining ALE meta-analysis and MACM analysis[J]. Brain Imaging Behav, 2025, 19(1): 204-217.
17. Spilling C A, Jones P W, Dodd J W, et al. Disruption of white matter connectivity in chronic obstructive pulmonary disease[J]. PLoS One, 2019, 14(10): e0223297.
18. Han K I, Yeo Y, Jo H J, et al. Abnormal Brain Functional Connectivity in Patients with Chronic Obstructive Pulmonary Disease and Correlations with Clinical and Cognitive Parameters[J]. Int J Chron Obstruct Pulmon Dis, 2025, 20: 971-985.
19. Jeong S M, Park J, Han K, et al. Association of Changes in Smoking Intensity With Risk of Dementia in Korea[J]. JAMA Netw Open, 2023, 6(1): e2251506.
20. Dobric A, De Luca S N, Spencer S J, et al. Novel pharmacological strategies to treat cognitive dysfunction in chronic obstructive pulmonary disease[J]. Pharmacol Ther, 2022, 233: 108017.
21. Zailani H, Satyanarayanan S K, Liao W C, et al. Omega-3 Polyunsaturated Fatty Acids in Managing Comorbid Mood Disorders in Chronic Obstructive Pulmonary Disease (COPD): A Review[J]. J Clin Med, 2023, 12(7).
22. Wen X H, Li Y, Han D, et al. The relationship between cognitive function and arterial partial pressure O2 in patients with COPD: A meta-analysis[J]. Medicine (Baltimore), 2018, 97(4): e9599.
23. Siraj R A. Comorbid Cognitive Impairment in Chronic Obstructive Pulmonary Disease (COPD): Current Understanding, Risk Factors, Implications for Clinical Practice, and Suggested Interventions[J]. Medicina (Kaunas), 2023, 59(4).
24. Wang Q, Zhong X, Gao P, et al. Association and interaction of blood homocysteine and p-tau217 levels with temporal cortical thinning and cognitive impairment in Alzheimer's disease[J]. Alzheimers Dement, 2025, 21(7): e70465.
25. Zhou S, Chen J, Cheng L, et al. Age-Dependent Association Between Elevated Homocysteine and Cognitive Impairment in a Post-stroke Population: A Prospective Study[J]. Front Nutr, 2021, 8: 691837.
26. Liu N, Wang H, Han B, et al. Correlation analysis between cerebral microangiopathy and autonomic nervous dysfunction[J]. Brain Behav, 2024, 14(2): e3391.
27. Song H, Bharadwaj P K, Raichlen D A, et al. Association of homocysteine-related subcortical brain atrophy with white matter lesion volume and cognition in healthy aging[J]. Neurobiol Aging, 2023, 121: 129-138.
28. Luo J, Yang W, Liu Y, et al. Construction and evaluation of nomogram for risk prediction of cognitive impairment in chronic obstructive pulmonary disease comorbidity[J]. BMC Psychol, 2025, 13(1): 273.
29. Sun Y, Koyama Y, Shimada S. Inflammation From Peripheral Organs to the Brain: How Does Systemic Inflammation Cause Neuroinflammation?[J]. Front Aging Neurosci, 2022, 14: 903455.
30. Figat M, Wi?niewska A, Plichta J, et al. Potential association between obstructive lung diseases and cognitive decline[J]. Front Immunol, 2024, 15: 1363373.
31. Van Zeller M, Mcnicholas W T. Sleep disordered breathing: OSA-COPD overlap[J]. Expert Rev Respir Med, 2024, 18(6): 369-379.
32. Wang Y, Li B, Li P, et al. Severe obstructive sleep apnea in patients with chronic obstructive pulmonary disease is associated with an increased prevalence of mild cognitive impairment[J]. Sleep Med, 2020, 75: 522-530.
33. Hansen K K, L?kke A, Jensen H I, et al. Examining the impact of obstructive sleep apnea on cognitive function in severe COPD[J]. Sleep Breath, 2024, 29(1): 59.
34. Panagioti M, Scott C, Blakemore A, et al. Overview of the prevalence, impact, and management of depression and anxiety in chronic obstructive pulmonary disease[J]. Int J Chron Obstruct Pulmon Dis, 2014, 9: 1289-306.
35. Shea S, Palka J M, Kulikova A, et al. Relationship between chronic obstructive pulmonary disease and cognition in an aging population[J]. J Psychosom Res, 2022, 161: 111000.
36. Fan Y, Zhang C, Fan Z, et al. Development and validation of a nomogram for predicting the risk of cognitive impairment among chronic obstructive pulmonary diseases[J]. Ann Med, 2025, 57(1): 2528448.
37. Rochester C L, Holland A E. Pulmonary Rehabilitation and Improved Survival for Patients With COPD[J]. Jama, 2020, 323(18): 1783-1785.
38. Ding K, Song F, Sun W, et al. Impact of exercise training on cognitive function in patients with COPD: a systematic review and meta-analysis of randomised controlled trials[J]. Eur Respir Rev, 2025, 34(175).
39. Song F, Ding K, Sun M, et al. Effect of 12-week head-down strong abdominal breathing on cognitive function in patients with stable chronic obstructive pulmonary disease: a single-centre randomised controlled trial protocol[J]. Trials, 2024, 25(1): 351.
40. Han M, Wu H, Xu H, et al. The relationship between social isolation and cognitive function in older patients with chronic obstructive pulmonary disease: a latent profile analysis[J]. BMC Geriatr, 2025, 25(1): 561.
41. Verduri A, O'neill M, Ghinassi F, et al. The use of the MoCA in cognitive impairment for older patients with Chronic Obstructive Pulmonary disease: A preliminary study[J]. Sci Prog, 2025, 108(3): 368504251347114.
42. Lv R, Zhao Y, Wang X, et al. GLP-1 analogue liraglutide attenuates CIH-induced cognitive deficits by inhibiting oxidative stress, neuroinflammation, and apoptosis via the Nrf2/HO-1 and MAPK/NF-κB signaling pathways[J]. Int Immunopharmacol, 2024, 142(Pt B): 113222.
43. Momeni Safarabadi A, Gholami M, Kordestani-Moghadam P, et al. The effect of rosemary hydroalcoholic extract on cognitive function and activities of daily living of patients with chronic obstructive pulmonary disease (COPD): A clinical trial[J]. Explore (NY), 2024, 20(3): 362-370.
44. Zailani H, Satyanarayanan S K, Liao W C, et al. Roles of Omega-3 Polyunsaturated Fatty Acids in Managing Cognitive Impairment in Chronic Obstructive Pulmonary Disease: A Review[J]. Nutrients, 2023, 15(20).
45. Zhang D W, Yang M M, Zhou M X, et al. Sestrin2 alleviates cognitive impairment via inhibiting hippocampus ferroptosis in cigarette smoke-induced chronic obstructive pulmonary disease[J]. Redox Biol, 2025, 85: 103673.
46. Lu K, Qu Y, Shi R, et al. Decoding COPD-related cognitive impairment: The protective potential of YTHDF1[J]. Cell Signal, 2026, 139: 112311.

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Chinese Journal of Respiratory and Critical Care Medicine

慢性阻塞性肺病合并認知障礙的研究進展

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