鐵死亡代謝通路研究進展及在急性肺損傷中的作用_Chinese Journal of Respiratory and Critical Care Medicine

Authors：

曹珍珍 , ZHAO Yingxue , QIN Hongqian ,  HU Junfeng

蚌埠醫學院第一附屬醫院呼吸與危重癥醫學科（安徽蚌埠 233000）;

Corresponding?author：

HU Junfeng, Email: bbmchjf@126.com

Keywords：

DOI：

10.7507/1671-6205.202204057

Video：

Export PDF Favorites Scan Get Citation

Abstract Full text Figures/Tables Video References Cited by

Citation： ZHAO Yingxue, QIN Hongqian, HU Junfeng. 鐵死亡代謝通路研究進展及在急性肺損傷中的作用. Chinese Journal of Respiratory and Critical Care Medicine, 2023, 22(3): 214-217. doi: 10.7507/1671-6205.202204057 Copy

1.	Dixon SJ, Lemberg KM, Lamprecht MR, et al. Ferroptosis: an iron-dependent form of non-apoptotic cell death. Cell, 2012, 149(5): 1060-1072.
2.	Long ME, Mallampalli RK, Horowitz JC. Pathogenesis of pneumonia and acute lung injury. Clin Sci (Lond), 2022, 136(10): 747-769.
3.	He RY, Liu BH, Xiong R, et al. Itaconate inhibits ferroptosis of macrophage via Nrf2 pathways against sepsis-induced acute lung injury. Cell Death Discov, 2022, 8(1): 43.
4.	Bao C, Liu C, Liu Q, et al. Liproxstatin-1 alleviates LPS/IL-13-induced bronchial epithelial cell injury and neutrophilic asthma in mice by inhibiting ferroptosis. Int Immunopharmacol, 2022, 109: 108770.
5.	Koppula P, Lei G, Zhang YL, et al. A targetable CoQ-FSP1 axis drives ferroptosis-and radiation-resistance in KEAP1 inactive lung cancers. Nat Commun, 2022, 13(1): 2206.
6.	Mao C, Liu XG, Zhang YL, et al. DHODH-mediated ferroptosis defence is a targetable vulnerability in cancer. Nature, 2021, 593(7860): 586-590.
7.	Wang FD, Min JX. DHODH tangoing with GPX4 on the ferroptotic stage. Sig Transduct Target Ther, 2021, 6(1): 244.
8.	Kraft VAN, Bezjian CT, Pfeiffer S, et al. GTP cyclohydrolase 1/tetrahydrobiopterin counteract ferroptosis through lipid remodeling. ACS Cent Sci, 2020, 6(1): 41-53.
9.	Soula M, Weber RA, Zilka O, et al. Metabolic determinants of cancer cell sensitivity to canonical ferroptosis inducers. Nat Chem Biol, 2020, 16(12): 1351-1360.
10.	Hu Q, Wei WH, Wu DQ, et al. Blockade of GCH1/BH4 axis activates ferritinophagy to mitigate the resistance of colorectal cancer to erastin-induced ferroptosis. Front Cell Dev Biol, 2022, 10: 810327.
11.	Li LB, Chai R, Zhang S, et al. Iron exposure and the cellular mechanisms linked to neuron degeneration in adult mice. Cells, 2019, 8(2): 198.
12.	Liang YD, Deng YB, Zhao J, et al. Ferritinophagy is involved in experimental subarachnoid hemorrhage-induced neuronal ferroptosis. Neurochem Res, 2022, 47(3): 692-700.
13.	Mayr L, Grabherr F, Schw?rzler J, et al. Dietary lipids fuel GPX4-restricted enteritis resembling Crohn's disease. Nat Commun, 2020, 11(1): 1775.
14.	Cao ZZ, Qin HQ, Huang YH, et al. Crosstalk of pyroptosis, ferroptosis, and mitochondrial aldehyde dehydrogenase 2-related mechanisms in sepsis-induced lung injury in a mouse model. Bioengineered, 2022, 13(3): 4810-4820.
15.	Bednash JS, Kagan VE, Englert JA, et al. Syrian hamsters as a model of lung injury with SARS-CoV-2 infection: pathologic, physiologic, and detailed molecular profiling. Transl Res, 2022, 240: 1-16.
16.	Doan LH, Chu LW, Huang ZY, et al. Virofree, an herbal medicine-based formula, interrupts the viral infection of delta and omicron variants of SARS-CoV-2. Front Pharmacol, 2022, 13: 905197.
17.	Xia HW, Zhang ZM, You FP. Inhibiting ACSL1-related ferroptosis restrains murine coronavirus infection. Viruses, 2021, 13(12): 2383.
18.	Dar HH, Tyurina YY, Mikulska-Ruminska K, et al. Pseudomonas aeruginosa utilizes host polyunsaturated phosphatidylethanolamines to trigger theft-ferroptosis in bronchial epithelium. J Clin Invest, 2018, 128(10): 4639-4653.
19.	Amaral EP, Foreman TW, Namasivayam S, et al. GPX4 regulates cellular necrosis and host resistance in Mycobacterium tuberculosis infection. J Exp Med, 2022, 219(11): e20220504.
20.	Tang XM, Liu JQ, Yao S, et al. Ferulic acid alleviates alveolar epithelial barrier dysfunction in sepsis-induced acute lung injury by activating the Nrf2/HO-1 pathway and inhibiting ferroptosis. Pharm Biol, 2022, 60(1): 2286-2294.
21.	Wang YM, Gong FC, Qi X, et al. Mucin 1 inhibits ferroptosis and sensitizes vitamin E to alleviate sepsis-induced acute lung injury through GSK3β/Keap1-Nrf2-GPX4 pathway. Oxid Med Cell Longev, 2022, 2022: 2405943.
22.	Uchida Y, Tsugawa T, Tanaka-Mizuno S, et al. Exclusion of emphysematous lung from dose-volume estimates of risk improves prediction of radiation pneumonitis. Radiat Oncol, 2017, 12(1): 160.
23.	Li YC, Cao YM, Xiao J, et al. Inhibitor of apoptosis-stimulating protein of p53 inhibits ferroptosis and alleviates intestinal ischemia/reperfusion-induced acute lung injury. Cell Death Differ, 2020, 27(9): 2635-2650.
24.	Wang Y, Dong Z, Zhang ZZ, et al. Postconditioning with irisin attenuates lung ischemia/reperfusion injury by suppressing ferroptosis via induction of the Nrf2/HO-1 signal axis. Oxid Med Cell Longev, 2022, 2022: 9911167.
25.	Jia DY, Zheng JY, Zhou YY, et al. Ferroptosis is involved in hyperoxic lung injury in neonatal rats. J Inflamm Res, 2021, 14: 5393-5401.
26.	Chou HC, Chen CM. Hyperoxia induces ferroptosis and impairs lung development in neonatal mice. Antioxidants (Basel), 2022, 11(4): 641.
27.	Qiu YB, Wan BB, Liu G, et al. Nrf2 protects against seawater drowning-induced acute lung injury via inhibiting ferroptosis. Respir Res, 2020, 21(1): 232.
28.	Li X, Chen JY, Yuan SJ, et al. Activation of the P62-Keap1-NRF2 pathway protects against ferroptosis in radiation-induced lung injury. Oxid Med Cell Longev, 2022, 2022: 8973509.
29.	周航, 李鳳, 牛建一, 等. 鐵死亡參與油酸誘導的小鼠急性肺損傷(英文). 生理學報, 2019, 71(5): 689-697.

1. Dixon SJ, Lemberg KM, Lamprecht MR, et al. Ferroptosis: an iron-dependent form of non-apoptotic cell death. Cell, 2012, 149(5): 1060-1072.
2. Long ME, Mallampalli RK, Horowitz JC. Pathogenesis of pneumonia and acute lung injury. Clin Sci (Lond), 2022, 136(10): 747-769.
3. He RY, Liu BH, Xiong R, et al. Itaconate inhibits ferroptosis of macrophage via Nrf2 pathways against sepsis-induced acute lung injury. Cell Death Discov, 2022, 8(1): 43.
4. Bao C, Liu C, Liu Q, et al. Liproxstatin-1 alleviates LPS/IL-13-induced bronchial epithelial cell injury and neutrophilic asthma in mice by inhibiting ferroptosis. Int Immunopharmacol, 2022, 109: 108770.
5. Koppula P, Lei G, Zhang YL, et al. A targetable CoQ-FSP1 axis drives ferroptosis-and radiation-resistance in KEAP1 inactive lung cancers. Nat Commun, 2022, 13(1): 2206.
6. Mao C, Liu XG, Zhang YL, et al. DHODH-mediated ferroptosis defence is a targetable vulnerability in cancer. Nature, 2021, 593(7860): 586-590.
7. Wang FD, Min JX. DHODH tangoing with GPX4 on the ferroptotic stage. Sig Transduct Target Ther, 2021, 6(1): 244.
8. Kraft VAN, Bezjian CT, Pfeiffer S, et al. GTP cyclohydrolase 1/tetrahydrobiopterin counteract ferroptosis through lipid remodeling. ACS Cent Sci, 2020, 6(1): 41-53.
9. Soula M, Weber RA, Zilka O, et al. Metabolic determinants of cancer cell sensitivity to canonical ferroptosis inducers. Nat Chem Biol, 2020, 16(12): 1351-1360.
10. Hu Q, Wei WH, Wu DQ, et al. Blockade of GCH1/BH4 axis activates ferritinophagy to mitigate the resistance of colorectal cancer to erastin-induced ferroptosis. Front Cell Dev Biol, 2022, 10: 810327.
11. Li LB, Chai R, Zhang S, et al. Iron exposure and the cellular mechanisms linked to neuron degeneration in adult mice. Cells, 2019, 8(2): 198.
12. Liang YD, Deng YB, Zhao J, et al. Ferritinophagy is involved in experimental subarachnoid hemorrhage-induced neuronal ferroptosis. Neurochem Res, 2022, 47(3): 692-700.
13. Mayr L, Grabherr F, Schw?rzler J, et al. Dietary lipids fuel GPX4-restricted enteritis resembling Crohn's disease. Nat Commun, 2020, 11(1): 1775.
14. Cao ZZ, Qin HQ, Huang YH, et al. Crosstalk of pyroptosis, ferroptosis, and mitochondrial aldehyde dehydrogenase 2-related mechanisms in sepsis-induced lung injury in a mouse model. Bioengineered, 2022, 13(3): 4810-4820.
15. Bednash JS, Kagan VE, Englert JA, et al. Syrian hamsters as a model of lung injury with SARS-CoV-2 infection: pathologic, physiologic, and detailed molecular profiling. Transl Res, 2022, 240: 1-16.
16. Doan LH, Chu LW, Huang ZY, et al. Virofree, an herbal medicine-based formula, interrupts the viral infection of delta and omicron variants of SARS-CoV-2. Front Pharmacol, 2022, 13: 905197.
17. Xia HW, Zhang ZM, You FP. Inhibiting ACSL1-related ferroptosis restrains murine coronavirus infection. Viruses, 2021, 13(12): 2383.
18. Dar HH, Tyurina YY, Mikulska-Ruminska K, et al. Pseudomonas aeruginosa utilizes host polyunsaturated phosphatidylethanolamines to trigger theft-ferroptosis in bronchial epithelium. J Clin Invest, 2018, 128(10): 4639-4653.
19. Amaral EP, Foreman TW, Namasivayam S, et al. GPX4 regulates cellular necrosis and host resistance in Mycobacterium tuberculosis infection. J Exp Med, 2022, 219(11): e20220504.
20. Tang XM, Liu JQ, Yao S, et al. Ferulic acid alleviates alveolar epithelial barrier dysfunction in sepsis-induced acute lung injury by activating the Nrf2/HO-1 pathway and inhibiting ferroptosis. Pharm Biol, 2022, 60(1): 2286-2294.
21. Wang YM, Gong FC, Qi X, et al. Mucin 1 inhibits ferroptosis and sensitizes vitamin E to alleviate sepsis-induced acute lung injury through GSK3β/Keap1-Nrf2-GPX4 pathway. Oxid Med Cell Longev, 2022, 2022: 2405943.
22. Uchida Y, Tsugawa T, Tanaka-Mizuno S, et al. Exclusion of emphysematous lung from dose-volume estimates of risk improves prediction of radiation pneumonitis. Radiat Oncol, 2017, 12(1): 160.
23. Li YC, Cao YM, Xiao J, et al. Inhibitor of apoptosis-stimulating protein of p53 inhibits ferroptosis and alleviates intestinal ischemia/reperfusion-induced acute lung injury. Cell Death Differ, 2020, 27(9): 2635-2650.
24. Wang Y, Dong Z, Zhang ZZ, et al. Postconditioning with irisin attenuates lung ischemia/reperfusion injury by suppressing ferroptosis via induction of the Nrf2/HO-1 signal axis. Oxid Med Cell Longev, 2022, 2022: 9911167.
25. Jia DY, Zheng JY, Zhou YY, et al. Ferroptosis is involved in hyperoxic lung injury in neonatal rats. J Inflamm Res, 2021, 14: 5393-5401.
26. Chou HC, Chen CM. Hyperoxia induces ferroptosis and impairs lung development in neonatal mice. Antioxidants (Basel), 2022, 11(4): 641.
27. Qiu YB, Wan BB, Liu G, et al. Nrf2 protects against seawater drowning-induced acute lung injury via inhibiting ferroptosis. Respir Res, 2020, 21(1): 232.
28. Li X, Chen JY, Yuan SJ, et al. Activation of the P62-Keap1-NRF2 pathway protects against ferroptosis in radiation-induced lung injury. Oxid Med Cell Longev, 2022, 2022: 8973509.
29. 周航, 李鳳, 牛建一, 等. 鐵死亡參與油酸誘導的小鼠急性肺損傷(英文). 生理學報, 2019, 71(5): 689-697.

Previous Article
熒光假單胞菌引起肺炎合并胸腔積液一例
Next Article
嗜酸性粒細胞在急性呼吸窘迫綜合征中的研究進展

Chinese Journal of Respiratory and Critical Care Medicine

鐵死亡代謝通路研究進展及在急性肺損傷中的作用

Abstract Full text Figures/Tables Video References Cited by

Previous Article

Next Article

Format

Content