氫氣在呼吸系統疾病模型中的應用及相關機制研究進展_Chinese Journal of Respiratory and Critical Care Medicine

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林瑩妮 ^1,2 , 周劍平 ^1,2 ,  李慶云 ^1,2

1. ;
2. ;

Corresponding?author：

李慶云, Email: liqingyun68@hotmail.com

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DOI：

10.7507/1671-6205.201807009

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Citation： 林瑩妮, 周劍平, 李慶云. 氫氣在呼吸系統疾病模型中的應用及相關機制研究進展. Chinese Journal of Respiratory and Critical Care Medicine, 2019, 18(3): 305-308. doi: 10.7507/1671-6205.201807009 Copy

1.	Ohsawa I, Ishikawa M, Takahashi K, et al. Hydrogen acts as a therapeutic antioxidant by selectively reducing cytotoxic oxygen radicals. Nat Med, 2007, 13(6): 688-694.
2.	Ohno K, Ito M, Ichihara M, et al. Molecular hydrogen as an emerging therapeutic medical gas for neurodegenerative and other diseases. Oxid Med Cell Longev, 2012, 2012: 353152.
3.	Lin Y, Ohkawara B, Ito M, et al. Molecular hydrogen suppresses activated Wnt/β-catenin signaling. Sci Rep, 2016, 6: 31986.
4.	Ning YY, Shang Y, Huang HD, et al. Attenuation of cigarette smoke-induced airway mucus production by hydrogen-rich saline in rats. PLoS One, 2013, 8: e83429.
5.	Liu X, Ma C, Wang X, et al. Hydrogen coadministration slows the development of COPD-like lung disease in a cigarette smoke-induced rat model. Int J Chron Obstruct Pulmon Dis, 2017, 12: 1309-1324.
6.	Suzuki Y, Sato T, Sugimoto M, et al. Hydrogen-rich pure water prevents cigarette smoke-induced pulmonary emphysema in SMP30 knockout mice. Biochem Biophys Res Commun, 2017, 492(1): 74-81.
7.	張寧, 張景熙. 吸入高濃度氫氣對大鼠支氣管哮喘的治療作用. 國際呼吸雜志, 2015, 35(3): 179-182.
8.	Xiao M, Zhu T, Wang T, et al. Hydrogen-rich saline reduces airway remodeling via inactivation of NF-κB in a murine model of asthma. Eur Rev Med Pharmacol Sci, 2013, 17(8): 1033-1043.
9.	Liu H, Liang X, Wang D, et al. Combination therapy with nitric oxide and molecular hydrogen in a murine model of acute lung injury. Shock, 2015, 43(5): 504-511.
10.	Xie K, Yu Y, Huang Y, et al. Molecular hydrogen ameliorates lipopolysaccharide-induced acute lung injury in mice through reducing inflammation and apoptosis. Shock, 2012, 37(5): 548-555.
11.	Qiu X, Li H, Tang H, et al. Hydrogen inhalation ameliorates lipopolysaccharide-induced acute lung injury in mice. Int Immunopharmacol, 2011, 11(12): 2130-2137.
12.	Zhang Y, Liu Y, Zhang J. Saturated hydrogen saline attenuates endotoxin-induced lung dysfunction. J Surg Res, 2015, 198(1): 41-49.
13.	Tao B, Liu L, Wang N, et al. Effects of hydrogen-rich saline on aquaporin 1, 5 in septic rat lungs. J Surg Res, 2016, 202(2): 291-298.
14.	Liu LD, Wu XY, Tao BD, et al. Protective effect and mechanism of hydrogen treatment on lung epithelial barrier dysfunction in rats with sepsis. Genet Mol Res, 2016, 15(1): gmr.15016050.
15.	Wang K, Song X, Duan S, et al. Hydrogen-rich saline prevents the down regulation of claudin-5 protein in septic rat lung via the PI3K/Akt signaling pathway. Int J Clin Exp Med, 2017, 10(8): 11717-11727.
16.	張紅濤, 劉玲玲, 于洋, 等. Rho/ROCK 信號通路在氫氣改善膿毒癥小鼠急性肺損傷中的作用. 中華危重病急救醫學, 2016, 28(5): 401-406.
17.	邊映雪, 秦超, 謝克亮, 等. 吸入氫氣對膿毒癥小鼠急性肺損傷時蛋白質組學的影響. 中華麻醉學雜志, 2017, 37(2): 218-223.
18.	Liu S, Liu K, Sun Q, et al. Consumption of hydrogen water reduces paraquat-induced acute lung injury in rats. J Biomed Biotechnol, 2011, 2011: 305086.
19.	Zhang HL, Liu YF, Luo XR, et al. Saturated hydrogen saline protects rats from acute lung injury induced by paraquat. World J Emerg Med, 2011, 2(2): 149-153.
20.	Ying Y, Xu H, Yao M, et al. Protective effect of hydrogen-saturated saline on acute lung injury induced by oleic acid in rats. J Orthop Surg Res, 2017, 12: 134.
21.	Diao M, Zhang S, Wu L, et al. Hydrogen gas inhalation attenuates seawater instillation-induced acute lung injury via the Nrf2 pathway in rabbits. Inflammation, 2016, 39(1): 2029-2039.
22.	Huang CS, Kawamura T, Lee S, et al. Hydrogen inhalation ameliorates ventilator-induced lung injury. Crit Care, 2010, 14(6): R234.
23.	Huang CS, Kawamura T, Peng X, et al. Hydrogen inhalation reduced epithelial apoptosis in ventilator-induced lung injury via a mechanism involving nuclear factor-kappa B activation. Biochem Biophys Res Commun, 2011, 408(2): 253-258.
24.	Terasaki Y, Suzuki T, Tonaki K, et al. Molecular hydrogen attenuates gefitinib-induced exacerbation of naphthalene-evoked acute lung injury through a reduction in oxidative stress and inflammation. Lab Invest, 2019 Feb 1.[Epub ahead of print].
25.	劉琪, 王大為, 陳興, 等. 氫氣對吸入性損傷大鼠急性肺損傷的保護作用及量效研究. 天津醫科大學學報, 2013, 19(6): 445-448.
26.	Fang Y, Fu XJ, Gu C, et al. Hydrogen-rich saline protects against acute lung injury induced by extensive burn in rat model. J Burn Care Res, 2011, 32(3): e82-e91.
27.	秦超, 邊映雪, 馮甜甜, 等. 氫對燒傷小鼠肺損傷炎癥反應時自噬的影響. 中華麻醉學雜志, 2018, 38(5): 610-613.
28.	Terasaki Y, Ohsawa I, Terasaki M, et al. Hydrogen therapy attenuates irradiation-induced lung damage by reducing oxidative stress. Am J Physiol Lung Cell Mol Physiol, 2011, 301(4): L415-L426.
29.	Kawamura T, Wakabayashi N, Shigemura N, et al. Hydrogen gas reduces hyperoxic lung injury via the Nrf2 pathway in vivo. Am J Physiol Lung Cell Mol Physiol, 2013, 304(10): L646-L656.
30.	Sun Q, Han W, Hu H, et al. Hydrogen alleviates hyperoxic acute lung injury related endoplasmic reticulum stress in rats through upregulation of SIRT1. Free Radic Res, 2017, 51(6): 622-632.
31.	Kawamura T, Huang CS, Tochigi N, et al. Inhaled hydrogen gas therapy for prevention of lung transplant-induced ischemia/reperfusion injury in rats. Transplantation, 2010, 90(12): 1344-1351.
32.	Kawamura T, Huang CS, Peng X, et al. The effect of donor treatment with hydrogen on lung allograft function in rats. Surgery, 2011, 150(2): 240-249.
33.	Zhou H, Fu Z, Wei Y, et al. Hydrogen inhalation decreases lung graft injury in brain-dead donor rats. J Heart Lung Transplant, 2013, 32(2): 251-258.
34.	Tanaka Y, Shigemura N, Kawamura T, et al. Profiling molecular changes induced by hydrogen treatment of lung allografts prior to procurement. Biochem Biophys Res Commun, 2012, 425(4): 873-879.
35.	Kohama K, Yamashita H, Aoyama-Ishikawa M, et al. Hydrogen inhalation protects against acute lung injury induced by hemorrhagic shock and resuscitation. Surgery, 2015, 158(2): 399-407.
36.	Choi J, Suk An E, Ban YH, et al. Hydrogen-enriched water eliminates fine particles from the lungs and blood by enhancing phagocytic activity. J Biomed Res, 2017.[Epub ahead of print].
37.	Wang DC, Wang LF, Zhang Y, et al. Hydrogen gas inhibits lung cancer progression through targeting SMC3. Biomed Pharmacother, 2018, 104: 788-797.
38.	Jiang Y, Liu G, Zhang L, et al. Therapeutic efficacy of hydrogen-rich saline alone and in combination with PI3K inhibitor in non-small cell lung cancer. Mol Med Rep, 2018, 18(2): 2182-2190.
39.	王東昌, 趙云霞, 趙志芳, 等. 氫氣干預抑制非小細胞肺癌生長的作用及其機制研究. 國際呼吸雜志, 2018, 38(8): 561-565.
40.	Itoh T, Fujita Y, Ito M, et al. Molecular hydrogen suppresses FcεRI-mediated signal transduction and prevents degranulation of mast. Biochem Biophys Res Commun, 2009, 389(4): 651-656.
41.	Ren JD, Ma J, Hou J, et al. Hydrogen-rich saline inhibits NLRP3 inflammasome activation and attenuates experimental acute pancreatitis in mice. Mediators Inflamm, 2014, 2014: 930894.
42.	Sobue S, Yamai K, Ito M, et al. Simultaneous oral and inhalational intake of molecular hydrogen additively suppresses signaling pathways in rodents. Mol Cell Biochem, 2015, 403(1-2): 231-241.
43.	Iuchi K, Imoto A, Kamimura N, et al. Molecular hydrogen regulates gene expression by modifying the free radical chain reaction-dependent generation of oxidized phospholipid mediators. Sci Rep, 2016, 6: 18971.
44.	Yoritaka A, Takanashi M, Hirayama M, et al. Pilot study of H? therapy in Parkinson's disease: a randomized double-blind placebo-controlled trial. Mov Disord, 2013, 28(6): 836-839.
45.	Song G, Lin Q, Zhao H, et al. Hydrogen Activates ATP-binding cassette transporter A1-dependent efflux ex vivo and improves high-density lipoprotein function in patients with hypercholesterolemia: a double-blinded, randomized, and placebo-controlled trial. J Clin Endocrinol Metab, 2015, 100(7): 2724-2733.
46.	Ishibashi T, Sato B, Rikitake M, et al. Consumption of water containing a high concentration of molecular hydrogen reduces oxidative stress and disease activity in patients with rheumatoid arthritis: an open-label pilot study. Med Gas Res, 2012, 2(1): 27.
47.	Nakao A, Toyoda Y, Sharma P, et al. Effectiveness of hydrogen rich water on antioxidant status of subjects with potential metabolic syndrome-an open label pilot study. J Clin Biochem Nutr, 2010, 46(2): 140-149.
48.	龔志晶, 關繼濤, 任雪珠, 等. 氫氣對環衛工人霧霾暴露肺保護性作用的研究. 中華結核和呼吸雜志, 2016, 39(12): 916-923.

1. Ohsawa I, Ishikawa M, Takahashi K, et al. Hydrogen acts as a therapeutic antioxidant by selectively reducing cytotoxic oxygen radicals. Nat Med, 2007, 13(6): 688-694.
2. Ohno K, Ito M, Ichihara M, et al. Molecular hydrogen as an emerging therapeutic medical gas for neurodegenerative and other diseases. Oxid Med Cell Longev, 2012, 2012: 353152.
3. Lin Y, Ohkawara B, Ito M, et al. Molecular hydrogen suppresses activated Wnt/β-catenin signaling. Sci Rep, 2016, 6: 31986.
4. Ning YY, Shang Y, Huang HD, et al. Attenuation of cigarette smoke-induced airway mucus production by hydrogen-rich saline in rats. PLoS One, 2013, 8: e83429.
5. Liu X, Ma C, Wang X, et al. Hydrogen coadministration slows the development of COPD-like lung disease in a cigarette smoke-induced rat model. Int J Chron Obstruct Pulmon Dis, 2017, 12: 1309-1324.
6. Suzuki Y, Sato T, Sugimoto M, et al. Hydrogen-rich pure water prevents cigarette smoke-induced pulmonary emphysema in SMP30 knockout mice. Biochem Biophys Res Commun, 2017, 492(1): 74-81.
7. 張寧, 張景熙. 吸入高濃度氫氣對大鼠支氣管哮喘的治療作用. 國際呼吸雜志, 2015, 35(3): 179-182.
8. Xiao M, Zhu T, Wang T, et al. Hydrogen-rich saline reduces airway remodeling via inactivation of NF-κB in a murine model of asthma. Eur Rev Med Pharmacol Sci, 2013, 17(8): 1033-1043.
9. Liu H, Liang X, Wang D, et al. Combination therapy with nitric oxide and molecular hydrogen in a murine model of acute lung injury. Shock, 2015, 43(5): 504-511.
10. Xie K, Yu Y, Huang Y, et al. Molecular hydrogen ameliorates lipopolysaccharide-induced acute lung injury in mice through reducing inflammation and apoptosis. Shock, 2012, 37(5): 548-555.
11. Qiu X, Li H, Tang H, et al. Hydrogen inhalation ameliorates lipopolysaccharide-induced acute lung injury in mice. Int Immunopharmacol, 2011, 11(12): 2130-2137.
12. Zhang Y, Liu Y, Zhang J. Saturated hydrogen saline attenuates endotoxin-induced lung dysfunction. J Surg Res, 2015, 198(1): 41-49.
13. Tao B, Liu L, Wang N, et al. Effects of hydrogen-rich saline on aquaporin 1, 5 in septic rat lungs. J Surg Res, 2016, 202(2): 291-298.
14. Liu LD, Wu XY, Tao BD, et al. Protective effect and mechanism of hydrogen treatment on lung epithelial barrier dysfunction in rats with sepsis. Genet Mol Res, 2016, 15(1): gmr.15016050.
15. Wang K, Song X, Duan S, et al. Hydrogen-rich saline prevents the down regulation of claudin-5 protein in septic rat lung via the PI3K/Akt signaling pathway. Int J Clin Exp Med, 2017, 10(8): 11717-11727.
16. 張紅濤, 劉玲玲, 于洋, 等. Rho/ROCK 信號通路在氫氣改善膿毒癥小鼠急性肺損傷中的作用. 中華危重病急救醫學, 2016, 28(5): 401-406.
17. 邊映雪, 秦超, 謝克亮, 等. 吸入氫氣對膿毒癥小鼠急性肺損傷時蛋白質組學的影響. 中華麻醉學雜志, 2017, 37(2): 218-223.
18. Liu S, Liu K, Sun Q, et al. Consumption of hydrogen water reduces paraquat-induced acute lung injury in rats. J Biomed Biotechnol, 2011, 2011: 305086.
19. Zhang HL, Liu YF, Luo XR, et al. Saturated hydrogen saline protects rats from acute lung injury induced by paraquat. World J Emerg Med, 2011, 2(2): 149-153.
20. Ying Y, Xu H, Yao M, et al. Protective effect of hydrogen-saturated saline on acute lung injury induced by oleic acid in rats. J Orthop Surg Res, 2017, 12: 134.
21. Diao M, Zhang S, Wu L, et al. Hydrogen gas inhalation attenuates seawater instillation-induced acute lung injury via the Nrf2 pathway in rabbits. Inflammation, 2016, 39(1): 2029-2039.
22. Huang CS, Kawamura T, Lee S, et al. Hydrogen inhalation ameliorates ventilator-induced lung injury. Crit Care, 2010, 14(6): R234.
23. Huang CS, Kawamura T, Peng X, et al. Hydrogen inhalation reduced epithelial apoptosis in ventilator-induced lung injury via a mechanism involving nuclear factor-kappa B activation. Biochem Biophys Res Commun, 2011, 408(2): 253-258.
24. Terasaki Y, Suzuki T, Tonaki K, et al. Molecular hydrogen attenuates gefitinib-induced exacerbation of naphthalene-evoked acute lung injury through a reduction in oxidative stress and inflammation. Lab Invest, 2019 Feb 1.[Epub ahead of print].
25. 劉琪, 王大為, 陳興, 等. 氫氣對吸入性損傷大鼠急性肺損傷的保護作用及量效研究. 天津醫科大學學報, 2013, 19(6): 445-448.
26. Fang Y, Fu XJ, Gu C, et al. Hydrogen-rich saline protects against acute lung injury induced by extensive burn in rat model. J Burn Care Res, 2011, 32(3): e82-e91.
27. 秦超, 邊映雪, 馮甜甜, 等. 氫對燒傷小鼠肺損傷炎癥反應時自噬的影響. 中華麻醉學雜志, 2018, 38(5): 610-613.
28. Terasaki Y, Ohsawa I, Terasaki M, et al. Hydrogen therapy attenuates irradiation-induced lung damage by reducing oxidative stress. Am J Physiol Lung Cell Mol Physiol, 2011, 301(4): L415-L426.
29. Kawamura T, Wakabayashi N, Shigemura N, et al. Hydrogen gas reduces hyperoxic lung injury via the Nrf2 pathway in vivo. Am J Physiol Lung Cell Mol Physiol, 2013, 304(10): L646-L656.
30. Sun Q, Han W, Hu H, et al. Hydrogen alleviates hyperoxic acute lung injury related endoplasmic reticulum stress in rats through upregulation of SIRT1. Free Radic Res, 2017, 51(6): 622-632.
31. Kawamura T, Huang CS, Tochigi N, et al. Inhaled hydrogen gas therapy for prevention of lung transplant-induced ischemia/reperfusion injury in rats. Transplantation, 2010, 90(12): 1344-1351.
32. Kawamura T, Huang CS, Peng X, et al. The effect of donor treatment with hydrogen on lung allograft function in rats. Surgery, 2011, 150(2): 240-249.
33. Zhou H, Fu Z, Wei Y, et al. Hydrogen inhalation decreases lung graft injury in brain-dead donor rats. J Heart Lung Transplant, 2013, 32(2): 251-258.
34. Tanaka Y, Shigemura N, Kawamura T, et al. Profiling molecular changes induced by hydrogen treatment of lung allografts prior to procurement. Biochem Biophys Res Commun, 2012, 425(4): 873-879.
35. Kohama K, Yamashita H, Aoyama-Ishikawa M, et al. Hydrogen inhalation protects against acute lung injury induced by hemorrhagic shock and resuscitation. Surgery, 2015, 158(2): 399-407.
36. Choi J, Suk An E, Ban YH, et al. Hydrogen-enriched water eliminates fine particles from the lungs and blood by enhancing phagocytic activity. J Biomed Res, 2017.[Epub ahead of print].
37. Wang DC, Wang LF, Zhang Y, et al. Hydrogen gas inhibits lung cancer progression through targeting SMC3. Biomed Pharmacother, 2018, 104: 788-797.
38. Jiang Y, Liu G, Zhang L, et al. Therapeutic efficacy of hydrogen-rich saline alone and in combination with PI3K inhibitor in non-small cell lung cancer. Mol Med Rep, 2018, 18(2): 2182-2190.
39. 王東昌, 趙云霞, 趙志芳, 等. 氫氣干預抑制非小細胞肺癌生長的作用及其機制研究. 國際呼吸雜志, 2018, 38(8): 561-565.
40. Itoh T, Fujita Y, Ito M, et al. Molecular hydrogen suppresses FcεRI-mediated signal transduction and prevents degranulation of mast. Biochem Biophys Res Commun, 2009, 389(4): 651-656.
41. Ren JD, Ma J, Hou J, et al. Hydrogen-rich saline inhibits NLRP3 inflammasome activation and attenuates experimental acute pancreatitis in mice. Mediators Inflamm, 2014, 2014: 930894.
42. Sobue S, Yamai K, Ito M, et al. Simultaneous oral and inhalational intake of molecular hydrogen additively suppresses signaling pathways in rodents. Mol Cell Biochem, 2015, 403(1-2): 231-241.
43. Iuchi K, Imoto A, Kamimura N, et al. Molecular hydrogen regulates gene expression by modifying the free radical chain reaction-dependent generation of oxidized phospholipid mediators. Sci Rep, 2016, 6: 18971.
44. Yoritaka A, Takanashi M, Hirayama M, et al. Pilot study of H? therapy in Parkinson's disease: a randomized double-blind placebo-controlled trial. Mov Disord, 2013, 28(6): 836-839.
45. Song G, Lin Q, Zhao H, et al. Hydrogen Activates ATP-binding cassette transporter A1-dependent efflux ex vivo and improves high-density lipoprotein function in patients with hypercholesterolemia: a double-blinded, randomized, and placebo-controlled trial. J Clin Endocrinol Metab, 2015, 100(7): 2724-2733.
46. Ishibashi T, Sato B, Rikitake M, et al. Consumption of water containing a high concentration of molecular hydrogen reduces oxidative stress and disease activity in patients with rheumatoid arthritis: an open-label pilot study. Med Gas Res, 2012, 2(1): 27.
47. Nakao A, Toyoda Y, Sharma P, et al. Effectiveness of hydrogen rich water on antioxidant status of subjects with potential metabolic syndrome-an open label pilot study. J Clin Biochem Nutr, 2010, 46(2): 140-149.
48. 龔志晶, 關繼濤, 任雪珠, 等. 氫氣對環衛工人霧霾暴露肺保護性作用的研究. 中華結核和呼吸雜志, 2016, 39(12): 916-923.

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氫氣在呼吸系統疾病模型中的應用及相關機制研究進展

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