Drug Resistance Analysis of 1995 Strains of Respiratory Tract Pathogens Isolated from Hospitalized Pediatric Patients with Respiratory Tract Infections_Chinese Journal of Respiratory and Critical Care Medicine

Authors：

ZhangXiuhong ¹ , LiLang ² ,  DongLiang ³ , GengXianlong ⁴

1. Department of Pharmacy, Wuxi People's Hospital Affiliated to Nanjing Medical University, Wuxi, Jiangsu, 214023, China;
2. ;
3. ;
4. ;

Corresponding?author：

DongLiang, Email: 38395234@qq.com

Keywords：

Hospitalized pediatric patients; Respiratory tract infection; Pathogen; Drug resistance

DOI：

10.7507/1671-6205.2016131

Video：

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Objective To investigate the distribution and drug resistance of the pathogens isolated from hospitalized pediatric patients with respiratory tract infections, and to provide guidance for empiric therapy. Methods Respiratory tract specimens from hospitalized pediatric patients with respiratory tract infections from 2011 to 2015 were collected, and the strains were identified and the drug susceptibility was tested. Results A total of 1995 strains of pathogens, 1281 (64.21%) from boys and 714 (35.79%) from girls, were isolated from 6236 specimens and the detection rate was 31.99%. The mean age of the hospitalized pediatric patients was (1.22±2.05) years (ranged from 1 day to 14 years). 1393 (69.82%) pediatric patients were younger than 1 year. Staphylococcus aureus, Escherichia coli, Klebsiella pneumoniae, Candida albicans and Acinetobacter baumannii ranked the top five species, accounting for 29.82%, 15.09%, 13.18%, 12.73% and 5.91%, respectively. 1995 strains included gram-negative bacteria (50.93%), gram-positive bacteria (35.29%), and fungi (13.78%). The resistance rate of Staphylococcus aureus to oxacillin was 31.76%, but it was 100% sensitive to vancomycin and linezolid. The resistant rate of gram-negative bacteria to imipenem was ranged from 1.52% to 5.93%. The resistant rate of gram-negative bacteria to ceftazidime, cefepime, piperacillin tazobactam and tobramycin was less than 30.00%. Conclusions The infants whose age are younger than 1 year comprise the majority of the hospitalized pediatric patients with respiratory tract infections. The proportion of male is more than that of female. Staphylococcus aureus and enterobacteriaceae were the main isolated pathogens. There is difference in drug resistance between different pathogens, so antibiotics should be chosen according to the results of drug sensitivity testing.

Citation： ZhangXiuhong, LiLang, DongLiang, GengXianlong. Drug Resistance Analysis of 1995 Strains of Respiratory Tract Pathogens Isolated from Hospitalized Pediatric Patients with Respiratory Tract Infections. Chinese Journal of Respiratory and Critical Care Medicine, 2016, 15(6): 572-576. doi: 10.7507/1671-6205.2016131 Copy

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1. Liu L, Johnson HL, Cousens S, et al. Global, regional, and national causes of child mortality:an updated systematic analysis for 2010 with time trends since 2000. Lancet, 2012, 37:2151-261.
2. 鄭輝, 彭亮, 卓廣超.兒童呼吸道感染病原體IgM抗體檢測結果分析.中華醫院感染學雜志, 2015, 25:235-237.
3. 黃容, 黃梁鑌, 田應敏, 等.連續3年兒科住院患者痰分離病原菌及耐藥性變遷.中國感染控制雜志, 2015, 14:236-239.
4. 胡亞美, 江載芳, 諸福棠.實用兒科學.第7版.北京:人民衛生出版社, 2002, 1163-1199.
5. 葛均波, 徐永健, 主編.內科學.第8版.北京:人民衛生出版社, 2013, 9.
6. Clinical and Laboratory Standards Institute. Performance Standards for Antimicrobial Susceptibility Testing; 24^th Informational Supplement, 2014, M100-S24.
7. 王曉麗, 俞趙軍, 繆琪.兒科患兒醫院呼吸道感染病原菌分布及耐藥性分析.中華醫院感染學雜志, 2014, 24:5673-5675.
8. 楊雙麗, 汪紅玲, 俞梅, 等.患兒下呼吸道感染病原菌的臨床調查與耐藥性分析.中華醫院感染學雜志, 2015, 25:3805-3807.
9. 陳華, 趙華, 袁擁華, 等.患兒下呼吸道感染病原菌分布與藥敏分析.中華醫院感染學雜志, 2015, 25:3570-3571, 3591.
10. 張秀紅, 董亮, 曹燕, 等.2011-2013年重癥監護病房鮑曼不動桿菌和銅綠假單胞菌耐藥性分析.現代預防醫學, 2015, 42:4013-4015.
11. 《抗菌藥物臨床應用指導原則》修訂工作組.抗菌藥物臨床應用指導原則.2015年版.北京:人民衛生出版社, 2015, 7.
12. 崔戰菊.兒童安全使用抗感染藥物的臨界年齡.臨床醫學, 2006, 26:81-82.
13. 陳潔, 李巖, 王晶, 等.耐甲氧西林金黃色葡萄球菌SCCmec基因分型及耐藥譜分析.中華醫院感染學雜志, 2012, 22:894-897.
14. 張艷, 王紅梅, 馬東禮.兒童感染肺炎鏈球菌的臨床分布及耐藥性分析.現代預防醫學, 2015, 42:3899-3912.
15. 楊青, 俞云松, 孫自鏞, 等.2011年中國CHINET呼吸道病原菌分布和耐藥性監測.中國感染與化療雜志, 2013, 13:357-364.
16. Clinical and Laboratory Standards Institute. Performance Standards for Antimicrobial Susceptibility Testing; 18^th Informational Supplement, 2008, M100-S18.
17. 張玲玲, 李廣起, 孫艷峰, 等.腫瘤住院患者感染病原菌與耐藥性研究.中華醫院感染學雜志, 2015, 25:3150-3152.

Chinese Journal of Respiratory and Critical Care Medicine

Drug Resistance Analysis of 1995 Strains of Respiratory Tract Pathogens Isolated from Hospitalized Pediatric Patients with Respiratory Tract Infections

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