青蒿琥酯在肺部疾病的研究進展_Chinese Journal of Respiratory and Critical Care Medicine

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駱瓊珍 ¹ ,  林江濤 ²

1. ;
2. ;

Corresponding?author：

林江濤, Email: jiangtao_l@263.net

Keywords：

DOI：

10.7507/1671-6205.2015147

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Citation： 駱瓊珍, 林江濤. 青蒿琥酯在肺部疾病的研究進展. Chinese Journal of Respiratory and Critical Care Medicine, 2015, 14(6): 611-614. doi: 10.7507/1671-6205.2015147 Copy

1.	?Winzeler EA, Manary MJ. Drug resistance genomics of the antimalarial drug artemisinin. Genome Biol,2014,15:544.
2.	Ndour PA, Lopera-Mesa TM, Diakité SA, et al. Plasmodium falciparum clearance is rapid and pitting independent in immune Malian children treated with artesunate for malaria. J Infect Dis,2015,211:290-297.
3.	Xu H, He Y, Yang X, et al. Anti-malarial agent artesunate inhibits TNF-a-induced production of proinflammatory cytokines via inhibition of NF-kB and PI3 kinase/Akt signal pathway in human rheumatoid arthritis fibroblast-like synoviocytes. Rheumatology,2007,46:920-926.
4.	Shahbazfar AA, Zare P, Ranjbaran M, et al. A survey on anticancer effects of artemisinin, iron, miconazole, and butyric acid on 5637 (bladder cancer) and 4T1 (Breast cancer) cell lines. J Cancer Res Ther,2014,10:1057-1062.
5.	Saeed ME, Kadioglu O, Seo EJ, et al. Quantitative structure-activity relationship and molecular docking of artemisinin derivatives to vascular endothelial growth factor receptor 1. Anticancer Res,2015,35:1929-1934.
6.	Liu L, Zuo LF, Zuo J, et al. Artesunate induces apoptosis and inhibits growth of Eca109 and Ec9706 human esophageal cancer cell lines in vitro and in vivo. Mol Med Rep,2015,12:1465-1472.
7.	Xu Y, Liu W, Fang B, et al. Artesunate ameliorates hepatic fibrosis induced by bovine serum albumin in rats through regulating matrix metalloproteinases. Eur J Pharmacol,2014,744:1-9.
8.	He R, Forman M, Mott BT, et al. Unique and highly selective anticytomegalovirus activities of artemisinin-derived dimer diphenyl phosphate stem from combination of dimer unit and a diphenyl phosphate moiety. Antimicrob Agents Chemother,2013,57:4208-4214.
9.	Edwards BK, Noone AM, Mariotto AB, et al. Annual Report to the Nation on the status of cancer, 1975-2010, featuring prevalence of comorbidity and impact on survival among persons with lung, colorectal, breast, or prostate cancer. Cancer,2014,120:1290-1314.
10.	Lin JJ, Lake J, Wall MM, et al. Association of patient-provider communication domains with lung cancer treatment. J Thorac Oncol,2014,9:1249-1254.
11.	Zhao Y, Jiang W, Li B, et al. Artesunate enhances radiosensitivity of human non-small cell lung cancer A549 cells via increasing NO production to induce cell cycle arrest at G2/M phase. Int Immunopharmacol,2011,11:2039-2046.
12.	Sequist LV, Bell DW, Lynch TJ, et al. Molecular predictors of response to epidermal growth factor receptor antagonists in non-small-cell lung cancer. J Clin Oncol,2007,25,587-595.
13.	Ma H, Yao Q, Zhang AM, et al. The effects of artesunate on the expression of EGFR and ABCG2 in A549 human lung cancer cells and a xenograft model.Molecules,2011,16:10556-10569.
14.	張祖貽,余世慶,苗立云,等.青蒿琥酯聯合NP方案治療中晚期非小細胞肺癌的隨機對照研究.中西醫結合學報,2008,6:134-138.
15.	Zhou C, Pan W, Wang XP, et al. Artesunate induces apoptosis via a Bak-mediated caspase-independent intrinsic pathway in human lung adenocarcinoma cells. J Cell Physiol,2012,227:3778-3786.
16.	苗立云,張祖貽.青蒿琥酯選擇性抗肺腺癌細胞的作用及機制.現代醫學,2006,34:15-17.
17.	Bao F, Yuan P, Yuan X, et al. Predictive risk factors for lymph node metastasis in patients with small size non-small cell lung cance. J Thorac Dis,2014,6:1697-1703.
18.	Rasheed SA, Efferth T, Asangani IA, et al. First evidence that the antimalarial drug artesunate inhibits invasion and in vivo metastasis in lung cancer by targeting essential extracellular proteases. Int J Cancer, 2010,127:1475-1485.
19.	Bergmann KC. Asthma. Chem Immunol Allergy,2014,100:69-80.
20.	Bice JB, Leechawengwongs E, Montanaro A. Biologic targeted therapy in allergic asthma. Ann Allergy Asthma Immunol,2014,112:108-115.
21.	Cheng C, Ho WE, Goh FY, et al. Anti-malarial drug artesunate attenuates experimental allergic asthma via inhibition of the phosphoinositide 3-kinase/Akt pathway. PLoS One,2011,6:e20932.
22.	Tan SS, Ong B, Cheng C. The antimalarial drug artesunate inhibits primary human cultured airway smooth muscle cell proliferation. Am J Respir Cell Mol Biol,2014,50:451-458.
23.	Ho WE, Cheng C, Peh HY, et al. Anti-malarial drug artesunate ameliorates oxidative lung damage in experimental allergic asthma. Free Radic Biol Med,2012,53:498-507.
24.	黃發軍,詹光杰,張宏.青蒿琥酯對哮喘大鼠肺組織TLR-4及TGF-β₁表達的影響.中國醫藥生物技術,2011,6:266-269.
25.	陳磊.青蒿琥酯對哮喘大鼠模型治療作用的實驗研究.2009(學位論文).
26.	Ng DS, Liao W, Tan Ws, et al. Anti-malarial drug artesunate protects against cigarette smoke-induced lung injury in mice. Phytomedicine,2014,21:1638-1644.
27.	Yao H, Hwang JW, Sundar IK, et al. SIRT1 redresses the imbalance of tissue inhibitor of matrix metalloproteinase-1 and matrix metalloproteinase-9 in the development of mouse emphysema and human COPD. Am J Physiol Lung Cell Mol Physiol,2013,305:L615-L624.
28.	Atkinson JJ, Lutey BA, Suzuki Y, et al. The role of matrix metalloproteinase-9 in cigarette smoke-induced emphysema. Am J Respir Crit Care Med,2011,183:876-884.
29.	Magenta D, Sangiovanni E, Basilico N, et al. Inhibition of metalloproteinase-9 secretion and gene expression by artemisinin derivatives. Acta Trop,2014,140:77-83.
30.	Geramizadeh B, Jowkar Z, Karami L, et al. Alpha-1 antitrypsin deficiency in Iranian patients with chronic obstructive pulmonary disease. Iran Red Crescent Med J,2013,15:e7508.
31.	Malhotra D, Thimmulappa R, Navas-Acien A, et al. Decline in NRF2-regulated antioxidants in chronic obstructive pulmonary disease lungs due to loss of its positive regulator, DJ-1. Am J Respir Crit Care Med,2008,178:592-604.
32.	Louhelainen N, Myllarniemi M, Rahman I, et al. Airway biomarkersof the oxidant burden in asthma and chronic obstructive pulmonary dis-ease:current and future perspectives. Int J Chron Obstruct Pulmon Dis,2008,3:585-603.
33.	Li HX, Wang HL, Wang HJ, et al. Artesunate restraining MAPK passage by smad7 to resist pulmonary fibrosis. Eur Rev Med Pharmacol Sci,2014,18:3199-3204.
34.	許光蘭,梁勁松,以敏,等.青蒿琥酯對肺纖維化大鼠肺組織轉化生長因子β₁的影響.廣西醫科大學學報,2008,25:400-403.
35.	許光蘭,陳平,梁勁松,等.青蒿琥酯對實驗性肺纖維化大鼠治療作用及其機理研究.臨床醫學工程,2009,16:6-8.
36.	王昌明,張孝飛,譚寧,等.青蒿琥酯對人胚肺成纖維細胞系HFL-1細胞增殖、凋亡的影響及機制.山東醫藥,2010,50:33-35.
37.	Ding DW, Zhang YH, Huang XE, et al. Bufalin induces mitochondrial pathway-mediated apoptosis in lung adenocarcinoma cells. Asian Pac J Cancer Prev,2014,15:10495-10500.
38.	王昌明,黎洪秀,張孝飛,等.Fas及FasL和Caspse-3在青蒿琥酯誘導人胚肺成纖維細胞凋亡中的表達.中國組織工程研究與臨床康復,2011,15:3785-3788.
39.	孫艷輝.青蒿琥酯對百草枯致大鼠肺損傷機制的干預性研究.2011(學位論文).
40.	孫瀝.百草枯中毒大鼠血清細胞因子的動態變化及青蒿琥酯的干預.2011(學位論文).

1. ?Winzeler EA, Manary MJ. Drug resistance genomics of the antimalarial drug artemisinin. Genome Biol,2014,15:544.
2. Ndour PA, Lopera-Mesa TM, Diakité SA, et al. Plasmodium falciparum clearance is rapid and pitting independent in immune Malian children treated with artesunate for malaria. J Infect Dis,2015,211:290-297.
3. Xu H, He Y, Yang X, et al. Anti-malarial agent artesunate inhibits TNF-a-induced production of proinflammatory cytokines via inhibition of NF-kB and PI3 kinase/Akt signal pathway in human rheumatoid arthritis fibroblast-like synoviocytes. Rheumatology,2007,46:920-926.
4. Shahbazfar AA, Zare P, Ranjbaran M, et al. A survey on anticancer effects of artemisinin, iron, miconazole, and butyric acid on 5637 (bladder cancer) and 4T1 (Breast cancer) cell lines. J Cancer Res Ther,2014,10:1057-1062.
5. Saeed ME, Kadioglu O, Seo EJ, et al. Quantitative structure-activity relationship and molecular docking of artemisinin derivatives to vascular endothelial growth factor receptor 1. Anticancer Res,2015,35:1929-1934.
6. Liu L, Zuo LF, Zuo J, et al. Artesunate induces apoptosis and inhibits growth of Eca109 and Ec9706 human esophageal cancer cell lines in vitro and in vivo. Mol Med Rep,2015,12:1465-1472.
7. Xu Y, Liu W, Fang B, et al. Artesunate ameliorates hepatic fibrosis induced by bovine serum albumin in rats through regulating matrix metalloproteinases. Eur J Pharmacol,2014,744:1-9.
8. He R, Forman M, Mott BT, et al. Unique and highly selective anticytomegalovirus activities of artemisinin-derived dimer diphenyl phosphate stem from combination of dimer unit and a diphenyl phosphate moiety. Antimicrob Agents Chemother,2013,57:4208-4214.
9. Edwards BK, Noone AM, Mariotto AB, et al. Annual Report to the Nation on the status of cancer, 1975-2010, featuring prevalence of comorbidity and impact on survival among persons with lung, colorectal, breast, or prostate cancer. Cancer,2014,120:1290-1314.
10. Lin JJ, Lake J, Wall MM, et al. Association of patient-provider communication domains with lung cancer treatment. J Thorac Oncol,2014,9:1249-1254.
11. Zhao Y, Jiang W, Li B, et al. Artesunate enhances radiosensitivity of human non-small cell lung cancer A549 cells via increasing NO production to induce cell cycle arrest at G2/M phase. Int Immunopharmacol,2011,11:2039-2046.
12. Sequist LV, Bell DW, Lynch TJ, et al. Molecular predictors of response to epidermal growth factor receptor antagonists in non-small-cell lung cancer. J Clin Oncol,2007,25,587-595.
13. Ma H, Yao Q, Zhang AM, et al. The effects of artesunate on the expression of EGFR and ABCG2 in A549 human lung cancer cells and a xenograft model.Molecules,2011,16:10556-10569.
14. 張祖貽,余世慶,苗立云,等.青蒿琥酯聯合NP方案治療中晚期非小細胞肺癌的隨機對照研究.中西醫結合學報,2008,6:134-138.
15. Zhou C, Pan W, Wang XP, et al. Artesunate induces apoptosis via a Bak-mediated caspase-independent intrinsic pathway in human lung adenocarcinoma cells. J Cell Physiol,2012,227:3778-3786.
16. 苗立云,張祖貽.青蒿琥酯選擇性抗肺腺癌細胞的作用及機制.現代醫學,2006,34:15-17.
17. Bao F, Yuan P, Yuan X, et al. Predictive risk factors for lymph node metastasis in patients with small size non-small cell lung cance. J Thorac Dis,2014,6:1697-1703.
18. Rasheed SA, Efferth T, Asangani IA, et al. First evidence that the antimalarial drug artesunate inhibits invasion and in vivo metastasis in lung cancer by targeting essential extracellular proteases. Int J Cancer, 2010,127:1475-1485.
19. Bergmann KC. Asthma. Chem Immunol Allergy,2014,100:69-80.
20. Bice JB, Leechawengwongs E, Montanaro A. Biologic targeted therapy in allergic asthma. Ann Allergy Asthma Immunol,2014,112:108-115.
21. Cheng C, Ho WE, Goh FY, et al. Anti-malarial drug artesunate attenuates experimental allergic asthma via inhibition of the phosphoinositide 3-kinase/Akt pathway. PLoS One,2011,6:e20932.
22. Tan SS, Ong B, Cheng C. The antimalarial drug artesunate inhibits primary human cultured airway smooth muscle cell proliferation. Am J Respir Cell Mol Biol,2014,50:451-458.
23. Ho WE, Cheng C, Peh HY, et al. Anti-malarial drug artesunate ameliorates oxidative lung damage in experimental allergic asthma. Free Radic Biol Med,2012,53:498-507.
24. 黃發軍,詹光杰,張宏.青蒿琥酯對哮喘大鼠肺組織TLR-4及TGF-β₁表達的影響.中國醫藥生物技術,2011,6:266-269.
25. 陳磊.青蒿琥酯對哮喘大鼠模型治療作用的實驗研究.2009(學位論文).
26. Ng DS, Liao W, Tan Ws, et al. Anti-malarial drug artesunate protects against cigarette smoke-induced lung injury in mice. Phytomedicine,2014,21:1638-1644.
27. Yao H, Hwang JW, Sundar IK, et al. SIRT1 redresses the imbalance of tissue inhibitor of matrix metalloproteinase-1 and matrix metalloproteinase-9 in the development of mouse emphysema and human COPD. Am J Physiol Lung Cell Mol Physiol,2013,305:L615-L624.
28. Atkinson JJ, Lutey BA, Suzuki Y, et al. The role of matrix metalloproteinase-9 in cigarette smoke-induced emphysema. Am J Respir Crit Care Med,2011,183:876-884.
29. Magenta D, Sangiovanni E, Basilico N, et al. Inhibition of metalloproteinase-9 secretion and gene expression by artemisinin derivatives. Acta Trop,2014,140:77-83.
30. Geramizadeh B, Jowkar Z, Karami L, et al. Alpha-1 antitrypsin deficiency in Iranian patients with chronic obstructive pulmonary disease. Iran Red Crescent Med J,2013,15:e7508.
31. Malhotra D, Thimmulappa R, Navas-Acien A, et al. Decline in NRF2-regulated antioxidants in chronic obstructive pulmonary disease lungs due to loss of its positive regulator, DJ-1. Am J Respir Crit Care Med,2008,178:592-604.
32. Louhelainen N, Myllarniemi M, Rahman I, et al. Airway biomarkersof the oxidant burden in asthma and chronic obstructive pulmonary dis-ease:current and future perspectives. Int J Chron Obstruct Pulmon Dis,2008,3:585-603.
33. Li HX, Wang HL, Wang HJ, et al. Artesunate restraining MAPK passage by smad7 to resist pulmonary fibrosis. Eur Rev Med Pharmacol Sci,2014,18:3199-3204.
34. 許光蘭,梁勁松,以敏,等.青蒿琥酯對肺纖維化大鼠肺組織轉化生長因子β₁的影響.廣西醫科大學學報,2008,25:400-403.
35. 許光蘭,陳平,梁勁松,等.青蒿琥酯對實驗性肺纖維化大鼠治療作用及其機理研究.臨床醫學工程,2009,16:6-8.
36. 王昌明,張孝飛,譚寧,等.青蒿琥酯對人胚肺成纖維細胞系HFL-1細胞增殖、凋亡的影響及機制.山東醫藥,2010,50:33-35.
37. Ding DW, Zhang YH, Huang XE, et al. Bufalin induces mitochondrial pathway-mediated apoptosis in lung adenocarcinoma cells. Asian Pac J Cancer Prev,2014,15:10495-10500.
38. 王昌明,黎洪秀,張孝飛,等.Fas及FasL和Caspse-3在青蒿琥酯誘導人胚肺成纖維細胞凋亡中的表達.中國組織工程研究與臨床康復,2011,15:3785-3788.
39. 孫艷輝.青蒿琥酯對百草枯致大鼠肺損傷機制的干預性研究.2011(學位論文).
40. 孫瀝.百草枯中毒大鼠血清細胞因子的動態變化及青蒿琥酯的干預.2011(學位論文).

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青蒿琥酯在肺部疾病的研究進展

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