Objective To present the diagnosis and treatment of a giant retroperitoneal liposarcoma (RPLS) involving the abdominal aorta, left renal hilum, pancreas, spleen, and left hemicolon under a multidisciplinary team (MDT) model. Methods  A retrospective study of the clinical data of a 34-year-old female patient with RPLS who admitted to the Department of Vascular Surgery, West China Hospital of Sichuan University in July 2024. Results Abdomina contrast-enhanced CT revealed a large heterogeneous mass in the retroperitoneum and abdominal cavity, with the largest cross-section measuring approximately 31.4 cm×28.4 cm. The mass demonstrated poorly defined border, pressing and encasing the pancreas, stomach, duodenum, spleen, left kidney, left adrenal gland, pancreatic body and tail. Tumor showed indistinct demarcation to adjacent intestinal canal and closely adjacent to the abdominal aorta, inferior vena cava and its major branches. After the initial MDT discussion, the patient underwent extended retroperitoneal tumor resection, combined pancreaticosplenectomy, left hemicolectomy, and repair of the abdominal aorta and left renal vessels. The tumor was completely resected, and the left kidney was successfully preserved. The procedure lasted approximately 6 h, with an estimated blood loss of 4 000 mL. The patient received 8 U suspended red blood cells and 600 mL fresh frozen plasma. One week postoperatively, the patient developed grade B pancreatic fistula, abdominal infection, jaundice, and post-splenectomy thrombocytosis (peak platelet count 1 285×10⁹/L), all of which were effectively managed after the second MDT consultation and coordinated treatment. The patient was discharged on postoperative day 20. Pathology confirmed dedifferentiated liposarcoma, graded as Fédération Nationale des Centres de Lutte Contre le Cancer grade 3. No tumor recurrence was observed during the 3-month follow-up. Conclusion In the management of complex giant RPLS involving critical major vessels and organs, a comprehensive MDT-guided approach, including meticulous preoperative planning, precise intraoperative manipulation and protection of organ function, systematic perioperative care, are essential to achieving successful outcomes and patient recovery.

Citation： TANG Youyin, ZHAO Jichun. Diagnosis and treatment of a giant retroperitoneal liposarcoma involving multiple organs and major vessels: a case report of MDT discussion. CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY, 2026, 33(3): 344-349. doi: 10.7507/1007-9424.202509144 Copy

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