Clinical application research and technical progress of amide proton transfer weighted imaging in breast cancer_CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

Authors：

ZHANG Liumei ¹ ,  YIN Longlin ^2,3

1. School of Medical Imaging, North Sichuan Medical College, Nanchong, Sichuan 637000, P. R. China;
2. Department of Radiology, Sichuan Academy of Medical Sciences & Sichuan Provincial People’s Hospital, Chengdu 610072, P. R. China;
3. Institute of Radiation Medicine, Sichuan Academy of Medical Sciences & Sichuan Provincial People’s Hospital, Chengdu 610072, P. R. China;

Corresponding?author：

YIN Longlin, Email: yinlonglin@163.com

Keywords：

breast cancer; amide proton transfer-weighted imaging; magnetic resonance imaging; progress

DOI：

10.7507/1007-9424.202509041

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Objective To comprehensively review the clinical application and technical progress of amide proton transfer weighted imaging (APTw) in breast cancer, and provide new ideas for the precise diagnosis and therapeutic evaluation of breast cancer. Method By searching relevant domestic and foreign literature, this paper reviews the technique principle of APTw, clinical research in breast cancer and the technical progress of APTw. Results APTw as a molecular functional imaging technique, can non-invasively detect the content of amide protons of proteins and peptides in tissues. It has demonstrated significant application value in differentiating benign and malignant breast lesions, molecular subtype prediction, tumor grading and staging evaluation, monitoring the efficacy of neoadjuvant chemotherapy, and early assessment of lymphedema. Technical optimization of APTw and integration with artificial intelligence provides new development directions for its clinical transformation. Conclusion APTw has a broad application prospect in the precise diagnosis and therapeutic evaluation of breast cancer, but its clinical application still needs to slove key issues such as standardization and reproducibility.

Citation： ZHANG Liumei, YIN Longlin. Clinical application research and technical progress of amide proton transfer weighted imaging in breast cancer. CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY, 2026, 33(4): 591-596. doi: 10.7507/1007-9424.202509041 Copy

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CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

Clinical application research and technical progress of amide proton transfer weighted imaging in breast cancer

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