GUO Zhipeng 1,2,3 , ZHANG Jian 2 , WAN Qiaoli 1,2 , SHI Fengyan 2 , LI Rui 2 , YIN Zongtao 2 , HAN Jinsong 1,2
  • 1. Graduate School, General Hospital of Northern Theater Command, China Medical University, Shenyang, 110016, P. R. China;
  • 2. Department of Cardiovascular Surgery, General Hospital of Northern Theater Command, Shenyang, 110016, P. R. China;
  • 3. Xiongan Xuanwu Hospital, Xiongan New Area, 071702, P. R. China;
HAN Jinsong, Email: hanjs0216@sina.com
Remote ischemic preconditioning; cardiac valve surgery; heart rate variability; autonomic nervous function; randomized controlled trial
10.7507/1007-4848.202401072
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Objective  To explore the effect of remote ischemic preconditioning (RIPC) on preoperative heart rate variability in patients with heart valves. Methods  Patients scheduled to undergo on-pump cardiac valve surgery in the Department of Cardiovascular Surgery, General Hospital of Northern Theater Command, between January and July 2022 were initially enrolled. Eligible patients were randomly assigned at a 1 : 1 ratio to either the RIPC group or the control group. Relevant indicators of heart rate variability [standard deviation of NN interval (SDNN), standard deviation of mean value of NN interval in every five minutes (SDANN), mean square root of difference between consecutive NN intervals (RMSSD), percentage of adjacent RR interval>50 ms (PNN50), low frequency (LF) component, high frequency (HF) component and LF/HF] at 8 hours in the morning on the surgical day between two groups were compared. Results  A total of 118 patients were initially assessed. After screening, 58 patients were excluded, and 60 patients provided written informed consent and were enrolled in the trial, with 30 allocated to the RIPC group and 30 to the control group. Seven patients in the control group and 5 patients in the RIPC group were subsequently excluded due to missing heart rate variability data resulting from cancelled operations. Finally, 23 patients in the control group and 25 patients in the RIPC group were included in the analysis. There was no statistical difference in baseline characteristics between the two groups, and there was no significant difference in heart rate variability 24 hours before intervention (P>0.05). After the intervention measures were taken, the comparison of the results of heart rate variability at 8 hours on the day of operation showed that SDNN and SDANN of patients in the RIPC group were higher than those in the control group, with statistical differences (P<0.05). Conclusion  RIPC can stabilize the preoperative heart rate variability of patients undergoing cardiac valve surgery.

Citation： GUO Zhipeng, ZHANG Jian, WAN Qiaoli, SHI Fengyan, LI Rui, YIN Zongtao, HAN Jinsong. Effect of remote ischemic preconditioning on preoperative heart rate variability in patients undergoing heart valve surgery: A randomized controlled trial. Chinese Journal of Clinical Thoracic and Cardiovascular Surgery, 2026, 33(4): 592-596. doi: 10.7507/1007-4848.202401072 Copy

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