腫瘤大小對各T分期胃癌患者預后影響的分析_CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

Authors：

 李小寶 ¹ , 姬樂 ¹ , 曹波 ¹ , 黃江 ¹ , 劉勇峰 ¹ , 白鐵成 ¹ , 梅樂園 ¹ , 車向明 ²

1. ;
2. ;

Corresponding?author：

李小寶, Email: lixiaobao2007@126.com

Keywords：

胃癌; 腫瘤大小; T分期; 預后

DOI：

10.7507/1007-9424.20160323

Video：

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目的探討腫瘤大小對各T分期胃癌患者預后的影響。方法收集535例行根治術胃癌患者的臨床資料，采用ROC曲線下面積取截斷點，根據腫瘤直徑分為＜4.5 cm組和≥4.5 cm組。應用Kaplan-Meier生存曲線比較相同T分期中不同腫瘤大小對胃癌患者預后的影響。結果腫瘤直徑＜4.5 cm組和≥4.5 cm組患者術后5年累積生存率分別為66.9%和28.3%，其差異有統計學意義（P＜0.05）。在T1期患者中，腫瘤直徑≥4.5 cm組與＜4.5 cm組之間預后差異無統計學意義（P＞0.05）；在T2及T3期患者中，腫瘤直徑≥4.5 cm組和＜4.5 cm組之間預后差異有統計學意義（P＜0.05）；在T4期患者中，腫瘤直徑≥4.5 cm組和＜4.5 cm組之間預后差異無統計學意義（P＞0.05）。結論腫瘤大小是影響T2及T3期胃癌患者預后的重要因素之一。

Citation： 李小寶, 姬樂, 曹波, 黃江, 劉勇峰, 白鐵成, 梅樂園, 車向明. 腫瘤大小對各T分期胃癌患者預后影響的分析. CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY, 2016, 23(10): 1262-1264. doi: 10.7507/1007-9424.20160323 Copy

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11.	Li C, Oh SJ, Kim S, et al. Risk factors of survival and surgical treatment for advanced gastric cancer with large tumor size. J Gastrointest Surg, 2009, 13(5):881-885.
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13.	Zu H, Wang F, Ma Y, et al. Stage-stratified analysis of prognostic significance of tumor size in patients with gastric cancer. PLoS One, 2013, 8(1):e54502.
14.	Huang CM, Xu M, Wang JB, et al. Is tumor size a predictor of preoperative N staging in T2-T4a stage advanced gastric cancer? Surg Oncol, 2014,23(1):5-10.
15.	Hyung WJ, Noh SH, Yoo CH, et al. Prognostic significance of metastatic lymph node ration in T3 gastric cancer. World J Surg, 2002, 26(3):323-329.
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1. Jemal A, Bray F, Center MM, et al. Global cancer statistics. CA Cancer J Clin, 2011, 61(2):69-90.
2. Saito H, Fukumoto Y, Osaki T, et al. Prognostic signifcance of level and number of lymph node metastases in patients with gastric cancer. Ann Surg Oncol, 2007, 14(5):1688-1693.
3. Liu X, Xu Y, Long Z, et al. Prognostic significance of tumor size in T3 gastric cancer. Ann Surg Oncol, 2009, 16(7):1875-1882.
4. Japanese Gastric Cancer Association. Janpanese classification of gastric carcinoma:3rd English edition. Gastric Cancer, 2011, 14(2):101-112.
5. Yokota T, Ishiyama S, Saito T, et al. Is tumor size a prognostic indicator for gastric carcinoma? Anticancer Res, 2002, 22(6B):3673-3677.
6. Im WJ, Kim MG, Ha TK, et al. Tumor size as a prognostic factor in gastric cancer patient. J Gastric Cancer, 2012, 12(3):164-172.
7. Mohri Y, Tanaka K, Ohi M, et al. Prognostic significance of host- and tumor-related factors in patients with gastric cancer. World J Surg, 2010, 34(2):285-290.
8. 張梅玲,王建,施偉,等. 腫瘤直徑對胃癌患者預后判斷價值的分析. 南京醫科大學學報:自然科學版,2011, 31(2):229-234.
9. Lu J, Huang CM, Zheng CH, et al. Prognostic value of tumor size in patients with remnant gastric cancer:is the seventh UICC stage sufficient for predicting prognosis? PLoS One, 2014, 9(12):e115776.
10. Li XB, Cao B, Mei LY, et al. Mulitivariate analysis of prognostic factors in 549 patients undergoing surgical treatment of gastric cancer. Hepatogastroenterology, 2014, 130(61):535-542.
11. Li C, Oh SJ, Kim S, et al. Risk factors of survival and surgical treatment for advanced gastric cancer with large tumor size. J Gastrointest Surg, 2009, 13(5):881-885.
12. Kikuchi S, Katada N, Sakuramoto S, et al. Survival after surgical treatment of early gastric cancer:surgical techniques and long term survival. Langenbecks Arch Surg, 2004, 389(2):69-74.
13. Zu H, Wang F, Ma Y, et al. Stage-stratified analysis of prognostic significance of tumor size in patients with gastric cancer. PLoS One, 2013, 8(1):e54502.
14. Huang CM, Xu M, Wang JB, et al. Is tumor size a predictor of preoperative N staging in T2-T4a stage advanced gastric cancer? Surg Oncol, 2014,23(1):5-10.
15. Hyung WJ, Noh SH, Yoo CH, et al. Prognostic significance of metastatic lymph node ration in T3 gastric cancer. World J Surg, 2002, 26(3):323-329.
16. Wang HM, Huang CM, Zheng CH, et al. Tumor size as a prognostic factor in patients with advanced gastric cancer in the lower third of the stomach. World J Gastroenterol, 2012, 18(38):5470-5475.

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腫瘤大小對各T分期胃癌患者預后影響的分析

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