Clinical analysis of CT-guided percutaneous microwave ablation therapy for 39 patients with primary lung cancer_Chinese Journal of Clinical Thoracic and Cardiovascular Surgery

Authors：

 劉勇恩 , 馬幸生

四川省遂寧市中心醫院胸外科（四川遂寧 ?629000）;

Corresponding?author：

劉勇恩, Email: 494988921@qq.com

Keywords：

微波消融; 周圍性肺癌; CT 引導

DOI：

10.7507/1007-4848.201605017

Video：

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目的探索無法行手術及化放療等治療措施的原發性周圍性肺癌患者行微波消融治療的安全性及效果。方法我院 2013 年 12 月至 2015 年 11 月 39 例原發性肺癌患者（其中男 24 例、女 15 例，年齡 44～83 歲，中位年齡 67 歲）行微波消融治療，腫瘤平均直徑 3.5 cm。評價腫瘤局部療效，隨訪時間 0.5～2.0 年。結果全組 39 例患者進行病灶消融后，病灶立即均質化，CT 值下降，供血終止，6 個月后病灶開始逐步縮小，瘢痕化。隨訪 39 例患者中有 3 例手術后生存 1.0～1.5 年因腫瘤全身廣泛轉移死亡；2 例患者手術后 6 個月復查增強 CT 見局部有少許血供予以再次消融；全組患者無 1 例嚴重并發癥發生。結論微波消融對原發性小細胞肺癌患者的治療效果佳、創傷小、手術風險小、安全性高。

Citation： 劉勇恩, 馬幸生. Clinical analysis of CT-guided percutaneous microwave ablation therapy for 39 patients with primary lung cancer. Chinese Journal of Clinical Thoracic and Cardiovascular Surgery, 2017, 24(6): 488-490. doi: 10.7507/1007-4848.201605017 Copy

1.	Gillams AR. Image guided tumour ablation. Cancer Imaging, 2005, 5: 103-109.
2.	Goldberg SN, Gazelle GS, Compton CC, et al.Treatment of intrahepatic malignancy with radiofrequency ablation: radiologic-pathologic correlation. Cancer, 2000, 88(11): 2452-2463.
3.	Soto Parra H, Latteri F, Cavina R, et al. Treatment perspectives in advanced non-small cell lung cancer. Tumori, 2000, 86(1): S36-41.
4.	仲樓, 丁懷銀, 曹飛, 等. CT 引導經皮穿刺微波消融治療周圍型肺癌 27 例臨床分析. 海南醫學, 2015, 7(26): 988-992.
5.	Fernarido HC, De Hoyos A, Landrenean RJ, et al. Radiofrequency ablation for the treatment of non-small cell lung cancer in marginal surgical candidates. J Thorac Cardiovasc Surg, 2005, 129(3): 639-644.
6.	支修益. 中國原發性肺癌診療規范. 中華腫瘤雜志, 2015, 37(1): 67-78.
7.	支修益, 劉寶東. 肺癌射頻消融的治療現狀與進展. 中華臨床肺癌雜志(電子版), 2009, 3(11): 1771-1778.
8.	盧強, 李小飛, 韓勇. 微波消融治療肺部惡性腫瘤的臨床療效分析. 中國醫藥, 2012, 7(5): 557-559.
9.	郭亞, 孫亞紅, 宋鵬遠, 等. CT 引導經皮穿刺微波消融肺部惡性腫瘤的臨床觀察. 臨床腫瘤學雜志, 2013, 18(7): 640-643.
10.	Wolf FJ, Aswad B, Ng T, et al. Intraoperative microwave ablation of pulmonary malignancies with tumor permittivity feedback control: ablation and resection study in 10 consecutive patients. Radiology, 2012, 262(1): 353-360.
11.	Schneider T, Heussel CP, Herth FJ, et al. Thermal ablation of malignant lung tumors. Dtsch Arztebl Int, 2013, 110(22): 394-400.
12.	郭晨陽, 胡鴻濤, 李海亮. CT 引導經皮穿刺微波治療周圍型肺癌. 當代醫學, 2009, 15(35): 674-676.
13.	Lencioni R, Crocetti I, Cioni R, et al. Response to radiofrequency ablation of pulmonary tumours: a prospective, intention-to-treat. multicentre clinical trial(the RAPTURE study).Lancet Oncol, 2008, 9(7): 621-628.
14.	Abbas G, Pennathur A, Landreneau RJ, et al. Radiofrequency and microwave ablation of lung tumors. J Surg Oncol, 2009, 100(8): 645-650.
15.	Wright AS, Sampson LA, Warner TF, et al. Radiofrequency versus microwave ablation in a hepatic porcine model. Radiology, 2005, 236(1): 132-139.
16.	李京華, 崔石昌, 孫健, 等. 原發性肝癌患者 CT 引導下經皮微波消融術腫瘤位置與疼痛程度的關系. 臨床肝膽病雜志, 2015, 31(C6): 903-906.
17.	Dupuy De, DiPetrillo T, Gandhi S, et al. Radiofrequency ablation followed by conventional radiotherapy for medically inoperable stage 1 non-small cell lung cancer. Chest, 2006, 129(3): 738-745.
18.	Goldberg SN, Grassi CJ, Cardella JF, et al. Image-guided tumor ablation: standardization of terminology and reporting criteria. J Vasc Interv Radiol, 2009, 20(7 Suppl): S377-S390.
19.	Lu Q, Cao W, Huang L, et al. CT-guided percutaneous microwave ablation of pulmonary malignancies: Results in 69 cases. World J Surg Oncol, 2012, 10: 80.
20.	Vogl TJ, Naguib NN, Gruber-Rouh T, et al. MicrowaVe ablation therapy: clinical utility in treatment of pulmonary metastases.Rdiology, 2011, 261(2): 643-651.

1. Gillams AR. Image guided tumour ablation. Cancer Imaging, 2005, 5: 103-109.
2. Goldberg SN, Gazelle GS, Compton CC, et al.Treatment of intrahepatic malignancy with radiofrequency ablation: radiologic-pathologic correlation. Cancer, 2000, 88(11): 2452-2463.
3. Soto Parra H, Latteri F, Cavina R, et al. Treatment perspectives in advanced non-small cell lung cancer. Tumori, 2000, 86(1): S36-41.
4. 仲樓, 丁懷銀, 曹飛, 等. CT 引導經皮穿刺微波消融治療周圍型肺癌 27 例臨床分析. 海南醫學, 2015, 7(26): 988-992.
5. Fernarido HC, De Hoyos A, Landrenean RJ, et al. Radiofrequency ablation for the treatment of non-small cell lung cancer in marginal surgical candidates. J Thorac Cardiovasc Surg, 2005, 129(3): 639-644.
6. 支修益. 中國原發性肺癌診療規范. 中華腫瘤雜志, 2015, 37(1): 67-78.
7. 支修益, 劉寶東. 肺癌射頻消融的治療現狀與進展. 中華臨床肺癌雜志(電子版), 2009, 3(11): 1771-1778.
8. 盧強, 李小飛, 韓勇. 微波消融治療肺部惡性腫瘤的臨床療效分析. 中國醫藥, 2012, 7(5): 557-559.
9. 郭亞, 孫亞紅, 宋鵬遠, 等. CT 引導經皮穿刺微波消融肺部惡性腫瘤的臨床觀察. 臨床腫瘤學雜志, 2013, 18(7): 640-643.
10. Wolf FJ, Aswad B, Ng T, et al. Intraoperative microwave ablation of pulmonary malignancies with tumor permittivity feedback control: ablation and resection study in 10 consecutive patients. Radiology, 2012, 262(1): 353-360.
11. Schneider T, Heussel CP, Herth FJ, et al. Thermal ablation of malignant lung tumors. Dtsch Arztebl Int, 2013, 110(22): 394-400.
12. 郭晨陽, 胡鴻濤, 李海亮. CT 引導經皮穿刺微波治療周圍型肺癌. 當代醫學, 2009, 15(35): 674-676.
13. Lencioni R, Crocetti I, Cioni R, et al. Response to radiofrequency ablation of pulmonary tumours: a prospective, intention-to-treat. multicentre clinical trial(the RAPTURE study).Lancet Oncol, 2008, 9(7): 621-628.
14. Abbas G, Pennathur A, Landreneau RJ, et al. Radiofrequency and microwave ablation of lung tumors. J Surg Oncol, 2009, 100(8): 645-650.
15. Wright AS, Sampson LA, Warner TF, et al. Radiofrequency versus microwave ablation in a hepatic porcine model. Radiology, 2005, 236(1): 132-139.
16. 李京華, 崔石昌, 孫健, 等. 原發性肝癌患者 CT 引導下經皮微波消融術腫瘤位置與疼痛程度的關系. 臨床肝膽病雜志, 2015, 31(C6): 903-906.
17. Dupuy De, DiPetrillo T, Gandhi S, et al. Radiofrequency ablation followed by conventional radiotherapy for medically inoperable stage 1 non-small cell lung cancer. Chest, 2006, 129(3): 738-745.
18. Goldberg SN, Grassi CJ, Cardella JF, et al. Image-guided tumor ablation: standardization of terminology and reporting criteria. J Vasc Interv Radiol, 2009, 20(7 Suppl): S377-S390.
19. Lu Q, Cao W, Huang L, et al. CT-guided percutaneous microwave ablation of pulmonary malignancies: Results in 69 cases. World J Surg Oncol, 2012, 10: 80.
20. Vogl TJ, Naguib NN, Gruber-Rouh T, et al. MicrowaVe ablation therapy: clinical utility in treatment of pulmonary metastases.Rdiology, 2011, 261(2): 643-651.

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Clinical analysis of CT-guided percutaneous microwave ablation therapy for 39 patients with primary lung cancer

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