RESEARCH PROGRESS OF SEVERED LIMB PRESERVATION BY PERFUSION_Chinese Journal of Reparative and Reconstructive Surgery

Authors：

QINXinyuan ¹ , ZHANGShaochun ² , GAOLei ² , YINYefeng ² , LIUNing ² ,  WANGJiangning ²

1. Graduate School of Capital Medical University, Beijing, 100069, P. R. China;
2. Department of Reparative and Reconstructive Surgery, Beijing Shijitan Hospital, Capital Medical University, Beijing, 100069, P. R. China;

Corresponding?author：

WANGJiangning, Email: doctorjnwang@163.com

Keywords：

Severed limb preservation; Perfusion; Ischemia-reperfusion injury

DOI：

10.7507/1002-1892.20140228

Video：

Export PDF Favorites Scan Get Citation

Abstract Full text Figures/Tables Video References Cited by

Objective To summarize the research progress of severed limb preservation by perfusion and to analyze difference in effect of severed limb preservation by different perfusate. Methods The domestic and foreign related literature about severed limb preservation by perfusion was extensively reviewed and analyzed. Results Currently the main perfusate includes organ perfusate,free radical scavengers,energy mixture,blood substitutes,and whole blood.They can reduce the skeletal muscle's ischemia-reperfusion injury in different degrees. Conclusion Different perfusate can reduce the skeletal muscle's ischemia-reperfusion injury in different degrees,but the best effect of perfusate and personalized preservation method need further study.

Citation： QINXinyuan, ZHANGShaochun, GAOLei, YINYefeng, LIUNing, WANGJiangning. RESEARCH PROGRESS OF SEVERED LIMB PRESERVATION BY PERFUSION. Chinese Journal of Reparative and Reconstructive Surgery, 2014, 28(8): 1047-1050. doi: 10.7507/1002-1892.20140228 Copy

1.	Gordon L,Levinsohn DG,Borowsky CD,et al.Improved preservation of skeletal muscle in amputated limbs using pulsatile hypothermic perfusion with University of Wisconsin solution.A preliminary study.J Bone Joint Surg (Am),1992,74(9):1358-1366.
2.	Kour AK,Phone MH,Chia J,et al.A preliminary report of tissue preservation with University of Wisconsin cold storage solution in major limb replantation.Ann Acad Med Singapore,1995,24(4Suppl):37-41.
3.	Wagh M,Pantazi G,Romeo R,et al.Cold storage of rat skeletal muscle free flaps and pre-ischemic perfusion with modified UW solution.Microsurgery,2000,20(7):343-349.
4.	Tsuchida T,Kato T,Yamaga M,et al.Effect of perfusion during ischemia on skeletal muscle.J Surg Res,2001,101(2):238-241.
5.	Tsuchida T,Kato T,Yamaga M,et al.The effect of perfusion with UW solution on the skeletal muscle and vascular endothelial exocrine function in rat hindlimbs.J Surg Res,2003,110(1):266-271.
6.	van der Heijden EP,Kroese AB,Werker PM,et al.Improving the preservation of isolated rat skeletal muscles stored for 16 hours at 4 degrees C.Transplantation,2000,69(7):1310-1322.
7.	王洪剛,劉小林,李智勇.UW液動脈預灌洗對缺血肢體再灌注損傷的影響.中山大學學報:醫學科學版,2013,34(6):856-860.
8.	王建枝,殷蓮華.病理生理學.8版.北京:人民衛生出版社,2013:142-145.
9.	Silvestro A,Scopacasa F,Oliva G,et al.Vitamin C prevents endothelial dysfunction induced by acute exercise in patients with intermittent claudication.Atherosclerosis,2002,165(2):277-283.
10.	Yan J,Tie G,Messina LM.Tetrahydrobiopterin,L-arginine and vitamin C act synergistically to decrease oxidant stress and increase nitricoxide that increases blood flow recovery after hindlimb ischemia in the rat.Mol Med,2012,18:1221-1230.
11.	趙克然,楊毅軍,曹道俊.氧自由基與臨床.北京:中國醫藥科技出版社,2000:19.
12.	Verkerk A,Jongkind JF.Vascular cells under peroxide induced oxidative stress:a balance study on in vitro peroxide handling by vascular endothelial and smooth muscle cells.Free Radic Res Commun,1992,17(2):121-132.
13.	李繼峰,顧玉東,袁偉,等.超氧化物歧化酶灌注對斷肢血管平滑肌和骨骼肌的保護作用.中華手外科雜志,1997,13(1):49-52.
14.	Rocca M,Giavaresi G,Caliceti P,et al.Pathophysiological and histomorphological evaluation of polyacryloylmorpholine vs polyethylene glycol modified superoxide dismutase in a rat model of ischaemia/reperfusion injury.Int J Artif Organs,1996,19(12):730-734.
15.	Giardino R,Giavaresi G,Fini M,et al.The role of different chemical modifications of superoxide dismutase in preventing a prolonged muscular ischemia/reperfusion injury.Artif Cells Blood Substit Immobil Biotechnol,2002,30(3):189-198.
16.	范里,杜飛,劉世清,等.丹參對肢體缺血再灌注損傷保護的實驗研究.中國中醫骨傷科雜志,2003,11(5):9-11.
17.	陳建常,史振滿,王樂農,等.丹參對缺血肢體關節軟骨及滑膜損傷的影響.骨與關節損傷雜志,2000,15(2):121-122.
18.	Tóth ? Jr,Pekárová T,Varga J,,et al.Intravenous administration of tetramethylpyrazine reduces intestinal ischemia-reperfusion injury in rats.Am J Chin Med,2013,41(4):817-829.
19.	陳雷,金可可,潘景業,等.葛根素對家兔肢體缺血再灌注后心臟功能的保護作用.中國中西醫結合外科雜志,2006,12(3):260-263.
20.	顧玉東,李繼峰,袁偉,等.離斷肢體血管與肌肉保護的實驗研究.中華創傷雜志,1996,12(1):2-5.
21.	劉曉鐘,陳忠勇,洪士東.低溫能量合劑持續灌注在超時斷肢再植中的應用.中華手外科雜志,1999,15(2):84.
22.	章偉文,李學淵,陳宏,等.能量合劑灌注對人離體骨骼肌超微結構的影響.現代實用醫學,2007,19(1):50-51.
23.	Sakata H.An experimental study of the effect of fluorocarbon perfusion for amputated limb preservation.The effect of inhibition for replantation toxemia and muscle tissue destruction.Nihon Seikeigeka Gakkai Zasshi,1984,58(5):497-508.
24.	Takahashi F.An experimental study on the effect of fluorocarbon perfusion for the preservation of an amputated limb.Nihon Seikeigeka Gakkai Zasshi,1987,61(10):1123-1134.
25.	Smith AR,van Alphen B,Faithfull NS,et al.Limb preservation in replantation surgery.Plast Reconstr Surg,1985,75(2):227-237.
26.	Xu S,Wang P,Wei K,et al.Cytoprotection of perfluorocarbon on PMVECs in vitro.Inflammation,2013,36(2):512-520.
27.	Delorme TL,Shaw RS,Austen WG.A method of studying "normal" function in the amputated human limb using perfusion.J Bone Joint Surg (Am),1964,46:161-164.
28.	Domingo-Pech J,Garriga JM,Toran N,et al.Preservation of the amputated canine hind limb by extracorporeal perfusion.Int Orthop,1991,15(4):289-291.
29.	Constantinescu MA,Knall E,Xu X,et al.Preservation of amputated extremities by extracorporeal blood perfusion; a feasibility study in a porcine model.J Surg Res,2011,171(1):291-299.
30.	Müller S,Constantinescu MA,Kiermeir DM,et al.Ischemia/reperfusion injury of porcine limbs after extracorporeal perfusion.J Surg Res,2013,181(1):170-182.
31.	尹葉鋒,王江寧,高磊,等.不同溫度對體外模擬體內生理環境寄養斷肢系統的影響研究.中國修復重建外科雜志,2013,27(1):72-76.
32.	黃慕康,于仲嘉,王澍寰,等.對斷肢(指)再植若干問題的討論.中華顯微外科雜志,1994,17(1):48-67.
33.	Lloyd MS,Teo TC,Pickford MA,et al.Preoperative management of the amputated limb.Emerg Med J,2005,22(7):478-480.

1. Gordon L,Levinsohn DG,Borowsky CD,et al.Improved preservation of skeletal muscle in amputated limbs using pulsatile hypothermic perfusion with University of Wisconsin solution.A preliminary study.J Bone Joint Surg (Am),1992,74(9):1358-1366.
2. Kour AK,Phone MH,Chia J,et al.A preliminary report of tissue preservation with University of Wisconsin cold storage solution in major limb replantation.Ann Acad Med Singapore,1995,24(4Suppl):37-41.
3. Wagh M,Pantazi G,Romeo R,et al.Cold storage of rat skeletal muscle free flaps and pre-ischemic perfusion with modified UW solution.Microsurgery,2000,20(7):343-349.
4. Tsuchida T,Kato T,Yamaga M,et al.Effect of perfusion during ischemia on skeletal muscle.J Surg Res,2001,101(2):238-241.
5. Tsuchida T,Kato T,Yamaga M,et al.The effect of perfusion with UW solution on the skeletal muscle and vascular endothelial exocrine function in rat hindlimbs.J Surg Res,2003,110(1):266-271.
6. van der Heijden EP,Kroese AB,Werker PM,et al.Improving the preservation of isolated rat skeletal muscles stored for 16 hours at 4 degrees C.Transplantation,2000,69(7):1310-1322.
7. 王洪剛,劉小林,李智勇.UW液動脈預灌洗對缺血肢體再灌注損傷的影響.中山大學學報:醫學科學版,2013,34(6):856-860.
8. 王建枝,殷蓮華.病理生理學.8版.北京:人民衛生出版社,2013:142-145.
9. Silvestro A,Scopacasa F,Oliva G,et al.Vitamin C prevents endothelial dysfunction induced by acute exercise in patients with intermittent claudication.Atherosclerosis,2002,165(2):277-283.
10. Yan J,Tie G,Messina LM.Tetrahydrobiopterin,L-arginine and vitamin C act synergistically to decrease oxidant stress and increase nitricoxide that increases blood flow recovery after hindlimb ischemia in the rat.Mol Med,2012,18:1221-1230.
11. 趙克然,楊毅軍,曹道俊.氧自由基與臨床.北京:中國醫藥科技出版社,2000:19.
12. Verkerk A,Jongkind JF.Vascular cells under peroxide induced oxidative stress:a balance study on in vitro peroxide handling by vascular endothelial and smooth muscle cells.Free Radic Res Commun,1992,17(2):121-132.
13. 李繼峰,顧玉東,袁偉,等.超氧化物歧化酶灌注對斷肢血管平滑肌和骨骼肌的保護作用.中華手外科雜志,1997,13(1):49-52.
14. Rocca M,Giavaresi G,Caliceti P,et al.Pathophysiological and histomorphological evaluation of polyacryloylmorpholine vs polyethylene glycol modified superoxide dismutase in a rat model of ischaemia/reperfusion injury.Int J Artif Organs,1996,19(12):730-734.
15. Giardino R,Giavaresi G,Fini M,et al.The role of different chemical modifications of superoxide dismutase in preventing a prolonged muscular ischemia/reperfusion injury.Artif Cells Blood Substit Immobil Biotechnol,2002,30(3):189-198.
16. 范里,杜飛,劉世清,等.丹參對肢體缺血再灌注損傷保護的實驗研究.中國中醫骨傷科雜志,2003,11(5):9-11.
17. 陳建常,史振滿,王樂農,等.丹參對缺血肢體關節軟骨及滑膜損傷的影響.骨與關節損傷雜志,2000,15(2):121-122.
18. Tóth ? Jr,Pekárová T,Varga J,,et al.Intravenous administration of tetramethylpyrazine reduces intestinal ischemia-reperfusion injury in rats.Am J Chin Med,2013,41(4):817-829.
19. 陳雷,金可可,潘景業,等.葛根素對家兔肢體缺血再灌注后心臟功能的保護作用.中國中西醫結合外科雜志,2006,12(3):260-263.
20. 顧玉東,李繼峰,袁偉,等.離斷肢體血管與肌肉保護的實驗研究.中華創傷雜志,1996,12(1):2-5.
21. 劉曉鐘,陳忠勇,洪士東.低溫能量合劑持續灌注在超時斷肢再植中的應用.中華手外科雜志,1999,15(2):84.
22. 章偉文,李學淵,陳宏,等.能量合劑灌注對人離體骨骼肌超微結構的影響.現代實用醫學,2007,19(1):50-51.
23. Sakata H.An experimental study of the effect of fluorocarbon perfusion for amputated limb preservation.The effect of inhibition for replantation toxemia and muscle tissue destruction.Nihon Seikeigeka Gakkai Zasshi,1984,58(5):497-508.
24. Takahashi F.An experimental study on the effect of fluorocarbon perfusion for the preservation of an amputated limb.Nihon Seikeigeka Gakkai Zasshi,1987,61(10):1123-1134.
25. Smith AR,van Alphen B,Faithfull NS,et al.Limb preservation in replantation surgery.Plast Reconstr Surg,1985,75(2):227-237.
26. Xu S,Wang P,Wei K,et al.Cytoprotection of perfluorocarbon on PMVECs in vitro.Inflammation,2013,36(2):512-520.
27. Delorme TL,Shaw RS,Austen WG.A method of studying "normal" function in the amputated human limb using perfusion.J Bone Joint Surg (Am),1964,46:161-164.
28. Domingo-Pech J,Garriga JM,Toran N,et al.Preservation of the amputated canine hind limb by extracorporeal perfusion.Int Orthop,1991,15(4):289-291.
29. Constantinescu MA,Knall E,Xu X,et al.Preservation of amputated extremities by extracorporeal blood perfusion; a feasibility study in a porcine model.J Surg Res,2011,171(1):291-299.
30. Müller S,Constantinescu MA,Kiermeir DM,et al.Ischemia/reperfusion injury of porcine limbs after extracorporeal perfusion.J Surg Res,2013,181(1):170-182.
31. 尹葉鋒,王江寧,高磊,等.不同溫度對體外模擬體內生理環境寄養斷肢系統的影響研究.中國修復重建外科雜志,2013,27(1):72-76.
32. 黃慕康,于仲嘉,王澍寰,等.對斷肢(指)再植若干問題的討論.中華顯微外科雜志,1994,17(1):48-67.
33. Lloyd MS,Teo TC,Pickford MA,et al.Preoperative management of the amputated limb.Emerg Med J,2005,22(7):478-480.

Previous Article
PROGRESS OF TREATMENT OF CUBITAL TUNNEL SYNDROME
Next Article
PROGRESS IN DISC DEGENERATION MODELS AND CALCITONIN THERAPY

Chinese Journal of Reparative and Reconstructive Surgery

RESEARCH PROGRESS OF SEVERED LIMB PRESERVATION BY PERFUSION

Abstract Full text Figures/Tables Video References Cited by

Previous Article

Next Article

Format

Content