醫用海藻酸基生物材料的研究進展_《中國修復重建外科雜志》

作者：

位曉娟 ^1,2 , 奚廷斐 ¹ , 顧其勝 ³ , 鄭玉峰 ²

北京大學（北京，100871）1前沿交叉學科研究院，2工學院;;
3上海其勝生物材料技術研究所;

關鍵詞：

海藻酸醫用生物材料臨床應用進展

DOI：

10.7507/1002-1892.20130220

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目的分析醫用海藻酸基生物材料的研究現況，重點介紹其在臨床領域的應用策略及研究進展，并討論該材料在臨床應用中需關注的重點問題。方法基于對國內外醫用海藻酸基生物材料研究的廣泛調研，并對國內外相關專利、文獻、醫藥制品進行檢索，綜合分析其研發、應用現況，提出應重點關注的幾個研究方向。結果醫用海藻酸基生物材料已在臨床廣泛應用，知識產權方面也有多項專利，但集中于創傷敷料和齒科印模領域。心衰治療、栓塞術、組織工程和干細胞培養作為較新的研究點有望成為該領域的發展新方向。結論醫用海藻酸基生物材料新產品的開發具有良好的臨床可行性和必要性，但作為新策略、新產品尚需進行大量的應用基礎研究。

引用本文： 位曉娟,奚廷斐,顧其勝,鄭玉峰. 醫用海藻酸基生物材料的研究進展. 中國修復重建外科雜志, 2013, 27(8): 1015-1020. doi: 10.7507/1002-1892.20130220 復制

1.	Lee KY, Mooney DJ. Alginate: Properties and biomedical applications. Prog Polym Sci, 2012, 37(1): 106-126.
2.	Draget KI, SKjåk-Braek G, Smidsrød O. Alginate based new materials. Int J Biol Macromol, 1997, 21(1-2): 47-55.
3.	王清華, 鐘文菲, 何盟. 藻酸鹽敷料的臨床應用: 與傳統材料特征的比較. 中國組織工程研究與臨床康復, 2010, 14(3): 533-536.
4.	Balakrishnan B, Mohanty M, Umashankar PR, et al. Evaluation of an in situ forming hydrogel wound dressing based on oxidized alginate and gelatin. Biomaterials, 2005, 26(32): 6335-6342.
5.	范一木, 李濤, 焦德讓, 等. APA介入顯影栓塞劑治療腦動靜脈畸形. 生物醫學工程與臨床, 2003, 7(2): 94-96.
6.	鄭江, 陳怡, 高亞輝, 等. 三種膠體材料及其復合物作為骨粘合劑的粘合強度比較. 中國海洋藥物雜志, 2009, 28(1): 26-28.
7.	顧東風, 黃廣勇, 何江, 等. 中國心力衰竭流行病學調查及其患病率. 中華心血管病雜志, 2003, 31(1): 3-6.
8.	Krum H, Abraham WT. Heart failure. Lancet, 2009, 373(9667): 941-955.
9.	Dahlmann J, Krause A, Möller L, et al. Fully defined in situ cross-linkable alginate and hyaluronic acid hydrogels for myocardial tissue engineering. Biomaterials, 2013, 34(4): 940-951.
10.	Landa N, Miller L, Feinberg MS, et al. Effect of injectable alginate implant on cardiac remodeling and function after recent and old infarcts in rat. Circulation, 2008, 117(1): 1388-1396.
11.	Leor J, Tuvia S, Guetta V, et al. Intracoronary injection of in situ forming alginate hydrogel reverse left ventricular remodeling after myocardial infarction in Swine. J Am Coll Cardiol, 2009, 54(11): 1014-1023.
12.	Oerlemans C, Seevinck PR, van de Maat GH, et al. Alginate-lanthanide microsphere for MRI-guided embolotherapy. Acta Biomater, 2013, 9(1): 4681-4687.
13.	Forster RE, Thürmer F, Wallrapp C, et al. Characterisation of physico-mechanical properties and degradation potential of calcium alginate beads for use in embolisation. J Mater Sci Mater Med, 2010, 21(7): 2243-2251.
14.	Lee KY, Peters MC, Mooney DJ. Comparison of vascular endothelial growth factor and basic fibroblast growth factor on angiogenesis in SCID mice. J Control Release, 2003, 87(1-3): 49-56.
15.	Sun Q, Silva EA, Wang A, et al. Sustained release of multiple growth factors from injectable polymeric system as a novel therapeutic approach towards angiogenesis. Pharm Res, 2010, 27(2): 264-271.
16.	Hao X, Silva EA, Mansson-Broberg A, et al. Angiogenic effects of sequential release of VEGF-A165 and PDGF-BB with alginate hydrogels after myocardial infarction. Cardiovasc Res, 2007, 75(1): 178-185.
17.	Ruvinov E, Leor J, Cohen S. The promotion of myocardial repair by the sequential delivery of IGF-1 and HGF from an injectable alginate biomaterial in a model of acute myocardial infarction. Biomaterials, 2011, 32(2): 565-578.
18.	Jay SM, Shepherd BR, Andrejecsk JW, et al. Dual delivery of VEGF and MCP-1 to support endothelial cell transplantation for therapeutic vascularization. Biomaterials, 2010, 31(11): 3054-3062.
19.	Silva EA, Kim ES, Kong HJ, et al. Material-based deployment enhances efficacy of endothelial progenitor cells. Proc Natl Acad Sci U S A, 2008, 105(38): 14347-14352.
20.	Wang CC, Yang KC, Lin KH, et al. A highly organized three-dimensional alginate scaffold for cartilage tissue engineering prepared by microfluidic technology. Biomaterials, 2011, 32(29): 7118-7126.
21.	Wang CC, Yang KC, Lin KH, et al. Cartilage regeneration in SCID mice using a highly organized three-dimensional alginate scaffold. Biomaterials, 2012, 33(1): 120-127.
22.	Thornton AJ, Alsberg E, Albertelli M, et al. Shape-defining scaffolds for minimally invasive tissue engineering. Transplantation, 2004, 77(12): 1798-1803.
23.	黃永波, 衛小春, 翁習生, 等. 海藻酸鈉-成年軟骨細胞培養移植修復成年兔關節軟骨缺損的研究. 中華實驗外科雜志, 2004, 21(8): 988-990.
24.	朱振宗, 梁偉國, 沈雁, 等. 海藻酸鈉復合載體長期培養軟骨細胞的生物學穩定性. 中國組織工程研究與臨床康復, 2011, 15(16): 2867-2870.
25.	Prang P, Müller R, Eljaouhari A, et al. The promotion of oriented axonal regrowth in the injured spinal cord by alginate-basedanisotropic capillary hydrogels. Biomaterials, 2006, 27(19): 3560-3569.
26.	Hashimoto T, Suzuki Y, Suzuki K, et al. Review: peripheral nerve regeneration using non-tubular alginate gel crosslinked with covalent bonds. J Mater Sci Mater Med, 2005, 16(6): 503-509.
27.	雄鷹, 王為, 于煒婷, 等. 微囊化雪旺細胞/神經組織移植促進周圍神經再生的實驗研究. 組織工程與重建外科雜志, 2005, 1(1): 18-21.
28.	汪大彬, 文益民, 藍旭, 等. 殼聚糖-藻酸鹽支架復合BMSCs修復急性脊髓損傷的實驗研究. 中國修復重建外科雜志, 2010, 24(2): 190-195.
29.	任利玲, 馮雪, 馬東洋, 等. 海藻酸鹽小球中培養的軟骨細胞的生長. 西安交通大學學報: 醫學版, 2011, 32(1): 57-61.
30.	Rowley JA, Mooney DJ. Alginate type and RGD density control myoblast phenotype. J Biomed Mater Res, 2002, 60(2): 217-223.
31.	李彩榮, 凌斌. 間充質干細胞與腫瘤生物治療. 國際腫瘤學雜志, 2011, 38(4): 254-256.
32.	那春鑫, 王彥紅, 王麟, 等. 干細胞治療糖尿病的研究進展. 生物醫學工程學進展, 2010, 31(2): 110-113.
33.	姚立松, 劉天慶, 葛丹, 等. 海藻酸鈣微膠珠培養神經干細胞研究. 中國生物醫學工程學報, 2007, 26(1): 126-133.

1. Lee KY, Mooney DJ. Alginate: Properties and biomedical applications. Prog Polym Sci, 2012, 37(1): 106-126.
2. Draget KI, SKjåk-Braek G, Smidsrød O. Alginate based new materials. Int J Biol Macromol, 1997, 21(1-2): 47-55.
3. 王清華, 鐘文菲, 何盟. 藻酸鹽敷料的臨床應用: 與傳統材料特征的比較. 中國組織工程研究與臨床康復, 2010, 14(3): 533-536.
4. Balakrishnan B, Mohanty M, Umashankar PR, et al. Evaluation of an in situ forming hydrogel wound dressing based on oxidized alginate and gelatin. Biomaterials, 2005, 26(32): 6335-6342.
5. 范一木, 李濤, 焦德讓, 等. APA介入顯影栓塞劑治療腦動靜脈畸形. 生物醫學工程與臨床, 2003, 7(2): 94-96.
6. 鄭江, 陳怡, 高亞輝, 等. 三種膠體材料及其復合物作為骨粘合劑的粘合強度比較. 中國海洋藥物雜志, 2009, 28(1): 26-28.
7. 顧東風, 黃廣勇, 何江, 等. 中國心力衰竭流行病學調查及其患病率. 中華心血管病雜志, 2003, 31(1): 3-6.
8. Krum H, Abraham WT. Heart failure. Lancet, 2009, 373(9667): 941-955.
9. Dahlmann J, Krause A, Möller L, et al. Fully defined in situ cross-linkable alginate and hyaluronic acid hydrogels for myocardial tissue engineering. Biomaterials, 2013, 34(4): 940-951.
10. Landa N, Miller L, Feinberg MS, et al. Effect of injectable alginate implant on cardiac remodeling and function after recent and old infarcts in rat. Circulation, 2008, 117(1): 1388-1396.
11. Leor J, Tuvia S, Guetta V, et al. Intracoronary injection of in situ forming alginate hydrogel reverse left ventricular remodeling after myocardial infarction in Swine. J Am Coll Cardiol, 2009, 54(11): 1014-1023.
12. Oerlemans C, Seevinck PR, van de Maat GH, et al. Alginate-lanthanide microsphere for MRI-guided embolotherapy. Acta Biomater, 2013, 9(1): 4681-4687.
13. Forster RE, Thürmer F, Wallrapp C, et al. Characterisation of physico-mechanical properties and degradation potential of calcium alginate beads for use in embolisation. J Mater Sci Mater Med, 2010, 21(7): 2243-2251.
14. Lee KY, Peters MC, Mooney DJ. Comparison of vascular endothelial growth factor and basic fibroblast growth factor on angiogenesis in SCID mice. J Control Release, 2003, 87(1-3): 49-56.
15. Sun Q, Silva EA, Wang A, et al. Sustained release of multiple growth factors from injectable polymeric system as a novel therapeutic approach towards angiogenesis. Pharm Res, 2010, 27(2): 264-271.
16. Hao X, Silva EA, Mansson-Broberg A, et al. Angiogenic effects of sequential release of VEGF-A165 and PDGF-BB with alginate hydrogels after myocardial infarction. Cardiovasc Res, 2007, 75(1): 178-185.
17. Ruvinov E, Leor J, Cohen S. The promotion of myocardial repair by the sequential delivery of IGF-1 and HGF from an injectable alginate biomaterial in a model of acute myocardial infarction. Biomaterials, 2011, 32(2): 565-578.
18. Jay SM, Shepherd BR, Andrejecsk JW, et al. Dual delivery of VEGF and MCP-1 to support endothelial cell transplantation for therapeutic vascularization. Biomaterials, 2010, 31(11): 3054-3062.
19. Silva EA, Kim ES, Kong HJ, et al. Material-based deployment enhances efficacy of endothelial progenitor cells. Proc Natl Acad Sci U S A, 2008, 105(38): 14347-14352.
20. Wang CC, Yang KC, Lin KH, et al. A highly organized three-dimensional alginate scaffold for cartilage tissue engineering prepared by microfluidic technology. Biomaterials, 2011, 32(29): 7118-7126.
21. Wang CC, Yang KC, Lin KH, et al. Cartilage regeneration in SCID mice using a highly organized three-dimensional alginate scaffold. Biomaterials, 2012, 33(1): 120-127.
22. Thornton AJ, Alsberg E, Albertelli M, et al. Shape-defining scaffolds for minimally invasive tissue engineering. Transplantation, 2004, 77(12): 1798-1803.
23. 黃永波, 衛小春, 翁習生, 等. 海藻酸鈉-成年軟骨細胞培養移植修復成年兔關節軟骨缺損的研究. 中華實驗外科雜志, 2004, 21(8): 988-990.
24. 朱振宗, 梁偉國, 沈雁, 等. 海藻酸鈉復合載體長期培養軟骨細胞的生物學穩定性. 中國組織工程研究與臨床康復, 2011, 15(16): 2867-2870.
25. Prang P, Müller R, Eljaouhari A, et al. The promotion of oriented axonal regrowth in the injured spinal cord by alginate-basedanisotropic capillary hydrogels. Biomaterials, 2006, 27(19): 3560-3569.
26. Hashimoto T, Suzuki Y, Suzuki K, et al. Review: peripheral nerve regeneration using non-tubular alginate gel crosslinked with covalent bonds. J Mater Sci Mater Med, 2005, 16(6): 503-509.
27. 雄鷹, 王為, 于煒婷, 等. 微囊化雪旺細胞/神經組織移植促進周圍神經再生的實驗研究. 組織工程與重建外科雜志, 2005, 1(1): 18-21.
28. 汪大彬, 文益民, 藍旭, 等. 殼聚糖-藻酸鹽支架復合BMSCs修復急性脊髓損傷的實驗研究. 中國修復重建外科雜志, 2010, 24(2): 190-195.
29. 任利玲, 馮雪, 馬東洋, 等. 海藻酸鹽小球中培養的軟骨細胞的生長. 西安交通大學學報: 醫學版, 2011, 32(1): 57-61.
30. Rowley JA, Mooney DJ. Alginate type and RGD density control myoblast phenotype. J Biomed Mater Res, 2002, 60(2): 217-223.
31. 李彩榮, 凌斌. 間充質干細胞與腫瘤生物治療. 國際腫瘤學雜志, 2011, 38(4): 254-256.
32. 那春鑫, 王彥紅, 王麟, 等. 干細胞治療糖尿病的研究進展. 生物醫學工程學進展, 2010, 31(2): 110-113.
33. 姚立松, 劉天慶, 葛丹, 等. 海藻酸鈣微膠珠培養神經干細胞研究. 中國生物醫學工程學報, 2007, 26(1): 126-133.

《中國修復重建外科雜志》

醫用海藻酸基生物材料的研究進展

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《中國修復重建外科雜志》

醫用海藻酸基生物材料的研究進展

摘要 全文 圖表 視頻 參考文獻 施引文獻 補充材料

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