酒精性股骨頭缺血性壞死的研究進展_《中國修復重建外科雜志》

作者：

甘迪 , 張長青

上海交通大學附屬第六人民醫院骨科（上海，200233）;

關鍵詞：

酒精性股骨頭缺血性壞死流行病學發病機制病因學

DOI：

10.7507/1002-1892.20130082

視頻：

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目的綜述酒精性股骨頭缺血性壞死（osteonecrosis of the femoral head，ONFH）的研究進展。方法廣泛查閱國內外近年與酒精性ONFH相關的文獻，并進行總結分析。結果酒精性ONFH患者約占ONFH患者的1/3。研究表明，酒精攝入量與ONFH發病具有明顯量效關系，酒精性ONFH發生與患者脂代謝、糖皮質激素分泌有關，與脂質和酒精代謝性基因存在相關性。結論酒精與脂代謝、激素的關系與作用機制仍是研究主要方向，基因水平研究尚不能闡釋發病機制，仍需深入研究。

引用本文： 甘迪,張長青. 酒精性股骨頭缺血性壞死的研究進展. 中國修復重建外科雜志, 2013, 27(3): 365-368. doi: 10.7507/1002-1892.20130082 復制

1.	World Health Organization. Global status report on alcohol and Health[EB/OL]. (2012-06-13)[2012-12-19] http: //www. who. int/entity/substance_abuse/publications/global_alcohol_report/msbgsrwpr. pdf.
2.	Lieberman JR, Berry DJ, Mont MA, et al. Osteonecrosis of the hip: management in the 21st century. Instr Course Lect, 2003, 52: 337-355.
3.	李子榮. 科學診斷和治療股骨頭壞死. 中國修復重建外科雜志, 2005, 19(9): 685-686.
4.	王鳳儀, 馬在山, 馬素英, 等. 山東中部地區人群股骨頭壞死流行病學調查研究. 中國骨傷, 2001, 14(6): 345-346.
5.	陳海濤, 安玉光, 張棟, 等. 廣西各地區酒精性股骨頭壞死的流行病學調查報告. 中國中醫藥資訊, 2010, 2(35): 277.
6.	Kang JS, Park S, Song JH, et al. Prevalence of osteonecrosis of the femoral head: a nationwide epidemiologic analysis in Korea. J Arthroplasty, 2009, 24(8): 1178-1183.
7.	Yamaguchi R, Yamamoto T, Motomura G, et al. Incidence of nontraumatic osteonecrosis of the femoral head in the Japanese population. Arthritis Rheum, 2011, 63(10): 3169-3173.
8.	Fukushima W, Fujioka M, Kubo T, et al. Nationwide epidemiologic survey of idiopathic osteonecrosis of the femoral head. Clin Orthop Relat Res, 2010, 468(10): 2715-2724.
9.	Gold EW, Cangemi PJ. Incidence and pathogenesis of alcohol-induced osteonecrosis of the femoral head. Clin Orthop Relat Res, 1979, (143): 222-226.
10.	Matsuo K, Hirohata T, Sugioka Y, et al. Influence of alcohol intake, cigarette smoking, and occupational status on idiopathic osteonecrosis of the femoral head. Clin Orthop Relat Res, 1988, (234): 115-123.
11.	Hirota Y, Hirohata T, Fukuda K, et al. Association of alcohol intake, cigarette smoking, and occupational status with the risk of idiopathic osteonecrosis of the femoral head. Am J Epidemiol, 1993, 137(5): 530-538.
12.	Corrao G, Rubbiati L, Bagnardi V, et al. Alcohol and coronary heart disease: a meta-analysis. Addiction, 2000, 95(10): 1505-1523.
13.	Choi HK, Atkinson K, Karlson EW, et al. Alcohol intake and risk of incident gout in men: a prospective study. Lancet, 2004, 363(9417): 1277-1281.
14.	石少輝, 李子榮, 孫偉, 等. 酒精性和激素性股骨頭壞死的發病與脂質代謝. 中國組織工程研究與臨床康復, 2011, 15(17): 3217-3220.
15.	Wang Y, Li Y, Mao K, et al. Alcohol-induced adipogenesis in bone and marrow: a possible mechanism for osteonecrosis. Clin Orthop Relat Res, 2003, (410): 213-224.
16.	Rico H, Gomez-Castresana F, Cabranes JA, et al. Increased blood cortisol in alcoholic patients with aseptic necrosis of the femoral head. Calcif Tissue Int, 1985, 37(6): 585-587.
17.	Badrick E, Bobak M, Britton A, et al. The relationship between alcohol consumption and cortisol secretion in an aging cohort. J Clin Endocrinol Metab, 2008, 93(3): 750-757.
18.	Cobb CF, Van Thiel DH. Mechanism of ethanol-induced adrenal stimulation. Alchol Clin Exp Res, 1982, 6(2): 202-206.
19.	趙鳳朝, 李子榮, 張念非. 不同病因股骨頭壞死的病理改變. 實用骨科雜志, 2005, 11(3): 210-213.
20.	Wall TL, Schoedel K, Ring HZ, et al. Differences in pharmacogenetics of nicotine and alcohol metabolism: review and recommendations for future research. Nicotine Tob Res, 2007, 9 Suppl 3: S459-474.
21.	Thomasson HR, Edenberg HJ, Crabb DW, et al. Alcohol and aldehyde dehydrogenase genotypes and alcoholism in Chinese men. Am J Hum Genet, 1991, 48 (4): 677-681.
22.	Sakata R. A case-control study of association between life-style, alcohol dehydrogenase 2 and aldehyde dehydrogenase 2 genotype and idiopathic osteonecrosis of the femoral head. Kurume Med J, 2003, 50 (3-4): 121-130.
23.	Chao YC, Wang SJ, Chu HC, et al. Investigation of alcohol metabolizing enzyme genes in Chinese alcoholics with avascular necrosis of hip joint, pancreatitis and cirrhosis of the liver. Alcohol Alcohol, 2003, 38(5): 431-436.
24.	Kim H, Cho C, Cho Y, et al. Significant associations of PAI-1 genetic polymorphisms with osteonecrosis of the femoral head. BMC Musculoskelet Disord, 2011, 12: 160.
25.	尹思, 張長青. 股骨頭壞死與基因遺傳多態性. 國際骨科學雜志, 2010, 31(3): 178-180, 189.

1. World Health Organization. Global status report on alcohol and Health[EB/OL]. (2012-06-13)[2012-12-19] http: //www. who. int/entity/substance_abuse/publications/global_alcohol_report/msbgsrwpr. pdf.
2. Lieberman JR, Berry DJ, Mont MA, et al. Osteonecrosis of the hip: management in the 21st century. Instr Course Lect, 2003, 52: 337-355.
3. 李子榮. 科學診斷和治療股骨頭壞死. 中國修復重建外科雜志, 2005, 19(9): 685-686.
4. 王鳳儀, 馬在山, 馬素英, 等. 山東中部地區人群股骨頭壞死流行病學調查研究. 中國骨傷, 2001, 14(6): 345-346.
5. 陳海濤, 安玉光, 張棟, 等. 廣西各地區酒精性股骨頭壞死的流行病學調查報告. 中國中醫藥資訊, 2010, 2(35): 277.
6. Kang JS, Park S, Song JH, et al. Prevalence of osteonecrosis of the femoral head: a nationwide epidemiologic analysis in Korea. J Arthroplasty, 2009, 24(8): 1178-1183.
7. Yamaguchi R, Yamamoto T, Motomura G, et al. Incidence of nontraumatic osteonecrosis of the femoral head in the Japanese population. Arthritis Rheum, 2011, 63(10): 3169-3173.
8. Fukushima W, Fujioka M, Kubo T, et al. Nationwide epidemiologic survey of idiopathic osteonecrosis of the femoral head. Clin Orthop Relat Res, 2010, 468(10): 2715-2724.
9. Gold EW, Cangemi PJ. Incidence and pathogenesis of alcohol-induced osteonecrosis of the femoral head. Clin Orthop Relat Res, 1979, (143): 222-226.
10. Matsuo K, Hirohata T, Sugioka Y, et al. Influence of alcohol intake, cigarette smoking, and occupational status on idiopathic osteonecrosis of the femoral head. Clin Orthop Relat Res, 1988, (234): 115-123.
11. Hirota Y, Hirohata T, Fukuda K, et al. Association of alcohol intake, cigarette smoking, and occupational status with the risk of idiopathic osteonecrosis of the femoral head. Am J Epidemiol, 1993, 137(5): 530-538.
12. Corrao G, Rubbiati L, Bagnardi V, et al. Alcohol and coronary heart disease: a meta-analysis. Addiction, 2000, 95(10): 1505-1523.
13. Choi HK, Atkinson K, Karlson EW, et al. Alcohol intake and risk of incident gout in men: a prospective study. Lancet, 2004, 363(9417): 1277-1281.
14. 石少輝, 李子榮, 孫偉, 等. 酒精性和激素性股骨頭壞死的發病與脂質代謝. 中國組織工程研究與臨床康復, 2011, 15(17): 3217-3220.
15. Wang Y, Li Y, Mao K, et al. Alcohol-induced adipogenesis in bone and marrow: a possible mechanism for osteonecrosis. Clin Orthop Relat Res, 2003, (410): 213-224.
16. Rico H, Gomez-Castresana F, Cabranes JA, et al. Increased blood cortisol in alcoholic patients with aseptic necrosis of the femoral head. Calcif Tissue Int, 1985, 37(6): 585-587.
17. Badrick E, Bobak M, Britton A, et al. The relationship between alcohol consumption and cortisol secretion in an aging cohort. J Clin Endocrinol Metab, 2008, 93(3): 750-757.
18. Cobb CF, Van Thiel DH. Mechanism of ethanol-induced adrenal stimulation. Alchol Clin Exp Res, 1982, 6(2): 202-206.
19. 趙鳳朝, 李子榮, 張念非. 不同病因股骨頭壞死的病理改變. 實用骨科雜志, 2005, 11(3): 210-213.
20. Wall TL, Schoedel K, Ring HZ, et al. Differences in pharmacogenetics of nicotine and alcohol metabolism: review and recommendations for future research. Nicotine Tob Res, 2007, 9 Suppl 3: S459-474.
21. Thomasson HR, Edenberg HJ, Crabb DW, et al. Alcohol and aldehyde dehydrogenase genotypes and alcoholism in Chinese men. Am J Hum Genet, 1991, 48 (4): 677-681.
22. Sakata R. A case-control study of association between life-style, alcohol dehydrogenase 2 and aldehyde dehydrogenase 2 genotype and idiopathic osteonecrosis of the femoral head. Kurume Med J, 2003, 50 (3-4): 121-130.
23. Chao YC, Wang SJ, Chu HC, et al. Investigation of alcohol metabolizing enzyme genes in Chinese alcoholics with avascular necrosis of hip joint, pancreatitis and cirrhosis of the liver. Alcohol Alcohol, 2003, 38(5): 431-436.
24. Kim H, Cho C, Cho Y, et al. Significant associations of PAI-1 genetic polymorphisms with osteonecrosis of the femoral head. BMC Musculoskelet Disord, 2011, 12: 160.
25. 尹思, 張長青. 股骨頭壞死與基因遺傳多態性. 國際骨科學雜志, 2010, 31(3): 178-180, 189.

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酒精性股骨頭缺血性壞死的研究進展

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酒精性股骨頭缺血性壞死的研究進展

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