Precise clinical application of physical agent therapy based on their “drug-like” mechanisms of action_West China Medical Journal

Authors：

CHEN Xinping ,  LUO Qinglu

The Fifth Clinical College, Guangzhou Medical University, Guangzhou, Guangdong 511436, P. R. China;

Corresponding?author：

LUO Qinglu, Email: 1443572213@qq.com

Keywords：

Physical agent therapy; precision medicine; rehabilitation; clinical decision-making

DOI：

10.7507/1002-0179.202602123

Video：

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Abstract Full text Figures/Tables Video References Cited by

Physical agent therapy is the core means of early rehabilitation and chronic disease intervention, but the clinical selection is currently not standardized. This article is based on the unique mechanisms of action of different physical agents, and systematically explores how to accurately select physical agent interventions for different systemic diseases, in order to achieve the goals of inhibiting pathological processes, enhancing drug efficacy, reducing medical costs, minimizing drug side effects, and reducing patient burden with individual or synergistic drugs. The aim is to provide practical reference for clinical workers to accurately select physical agent therapies and promote the standardization and efficiency of rehabilitation treatment.

Citation： CHEN Xinping, LUO Qinglu. Precise clinical application of physical agent therapy based on their “drug-like” mechanisms of action. West China Medical Journal, 2026, 41(6): 1011-1015. doi: 10.7507/1002-0179.202602123 Copy

1.	徐榮達, 張赫, 段思宇, 等. 脈沖電磁場對肌肉骨組織作用的研究進展. 中國矯形外科雜志, 2024, 32(3): 254-258.
2.	鄧葉龍, 孔令俊, 劉朝輝, 等. 脈沖電磁場對骨代謝的分子細胞學作用機制研究進展. 中國骨質疏松雜志, 2022, 28(2): 290-295.
3.	Nishi Y, Ikuno K, Minamikawa Y, et al. Tailored transcutaneous electrical nerve stimulation improves dysesthesia in individuals with spinal cord injury: a randomized N-of-1 trial. J Spinal Cord Med, 2025, 17: 1-10.
4.	燕鐵斌, 姜貴云, 吳軍, 等. 物理治療學. 北京: 人民衛生出版社, 2018.
5.	Yang X, Zhang X, Yin M, et al. Elastic compression stockings to prevent post-thrombotic syndrome in proximal deep venous thrombosis patients without thrombus removal. J Vasc Surg Venous Lymphat Disord, 2022, 10(2): 293-299.
6.	Jenkins S, Cross A, Osman H, et al. Effectiveness of biofeedback on blood pressure in patients with hypertension: systematic review and meta-analysis. J Hum Hypertens, 2024, 38(10): 719-727.
7.	董銘杰, 薛瑞君, 徐紫晴, 等. 低頻重復經顱磁刺激治療顱腦損傷后陣發性交感神經亢進 27 例療效觀察. 中華航海醫學與高氣壓醫學雜志, 2022, 29(4): 521-524, 549.
8.	Wang J, Li Z, Pan M, et al. Ultrasound-mediated blood-brain barrier opening: an effective drug delivery system for theranostics of brain diseases. Adv Drug Deliv Rev, 2022, 190: 114539.
9.	Sanwal R, Joshi K, Ditmans M, et al. Ultrasound and microbubbles for targeted drug delivery to the lung endothelium in ARDS: cellular mechanisms and therapeutic opportunities. Biomedicines, 2021, 9(7): 803.
10.	Li W, Li X, Kong Z, et al. Efficacy of low-intensity pulsed ultrasound in the treatment of COVID-19 pneumonia. Ultraschall Med, 2023, 44(6): e274-e283.
11.	任玲. 超短波治療重癥康復患者細菌性肺炎的隨機對照試驗. 成都: 四川大學, 2023.
12.	黃璽, 沈陽, 李小寒. 電針與促胃動力藥治療功能性便秘的系統評價. 針刺研究, 2020, 45(7): 592-598.
13.	蔣惠瑜, 周蔚, 明小紅, 等. 干擾電刺激八髎穴、大腸俞穴聯合莫沙必利治療糖尿病便秘患者療效觀察. 康復學報, 2021, 31(6): 501-507.
14.	何件根, 武亮. 超短波治療降低腦卒中患者下尿路感染發生率的臨床研究. 醫師在線, 2023, 13(7): 34-36.
15.	劉利杰, 陳鑫, 黃華偉, 等. 低能量體外沖擊波治療磷酸二酯酶-5 抑制劑無反應性勃起功能障礙療效研究. 中國男科學雜志, 2021, 35(2): 19-23.
16.	Kaadan A, Salati S, Setti S, et al. Augmentation of deficient bone healing by pulsed electromagnetic fields-from mechanisms to clinical outcomes. Bioengineering (Basel), 2024, 11(12): 1223.
17.	Masante B, Gabetti S, Silva JC, et al. Insights into bone and cartilage responses to pulsed electromagnetic field stimulation: a review with quantitative comparisons. Front Bioeng Biotechnol, 2025, 13: 1557572.
18.	蘇小強, 王向陽, 白晶晶. 低頻脈沖電磁療聯合唑來膦酸治療絕經后老年女性骨質疏松性椎體壓縮性骨折的臨床效果. 臨床醫學研究與實踐, 2022, 7(24): 1-4.
19.	夏駟捷, 廖琦. 低強度脈沖超聲治療骨折的系統回顧和薈萃分析. 中國組織工程研究, 2021, 25(12): 1944-1950.
20.	Leppik L, Oliveira KMC, Bhavsar MB, et al. Electrical stimulation in bone tissue engineering treatments. Eur J Trauma Emerg Surg, 2020, 46(2): 231-244.
21.	朱璐, 吳文忠, 陳銘, 等. 電針對原發性骨質疏松癥患者運動功能的影響: 隨機對照研究. 中國針灸, 2022, 42(2): 145-149.
22.	許紅娣. 電腦中頻電療對肩周炎患者關節疼痛及功能恢復的影響. 現代診斷與治療, 2021, 32(14): 2308-2309.
23.	李孟忠, 張建國, 梁文杰, 等. 溫針電針腰三針治療寒濕型慢性腰肌勞損: 隨機對照試驗. 中國針灸, 2025, 45(10): 1421-1426.
24.	朱志恒, 趙仙麗, 丁道芳, 等. 肌內效貼治療膝骨關節炎的作用機制研究進展. 按摩與康復醫學, 2022, 13(17): 55-60.
25.	李兆寶, 黃明勇, 羅君. 肌內效貼結合玻璃酸鈉注射治療膝骨關節炎的療效研究. 中國康復, 2019, 34(8): 423-425.
26.	El Melhat AM, Youssef ASA, Zebdawi MR, et al. Non-surgical approaches to the management of lumbar disc herniation associated with radiculopathy: a narrative review. J Clin Med, 2024, 13(4): 974.
27.	馬軍廷, 張振國, 袁燕, 等. 仰臥位手法牽引對神經根型頸椎病患者血清炎癥因子的影響. 分子診斷與治療雜志, 2021, 13(9): 1486-1489, 1493.
28.	Roman N, Miclaus RS, Necula R, et al. Physiotherapy efficiency in post-stroke upper extremity spasticity: TENS vs. ultrasound vs. paraffin. In Vivo, 2023, 37(2): 916-923.
29.	謝偉想, 陳蜀, 譚育華, 等. 蠟療治療兒童痙攣型腦癱臨床療效的 Meta 分析. 中國兒童保健雜志, 2021, 29(8): 881-885, 890.
30.	Ali S, Sun M, Khan MN, et al. Advances in sciatic nerve regeneration: a review of contemporary techniques. Regen Ther, 2025, 29: 563-574.
31.	陳易, 鄭曉, 李巖峰. 電針聯合口服甲鈷胺片治療 2 型糖尿病合并輕中度腕管綜合征臨床研究. 國際中醫中藥雜志, 2021, 43(3): 242-245.
32.	胡曉穎, 雷鴻雁, 馬珊珊, 等. 重復經顱磁刺激配合丁苯酞軟膠囊治療帕金森合并認知功能障礙患者的效果. 中國當代醫藥, 2023, 30(20): 46-49.
33.	張瑩, 徐文成, 陳秋妍, 等. 基于“生物全息論”探析多參數生物反饋干預治療廣泛性焦慮障礙的生物學機制. 國際精神病學雜志, 2025, 52(2): 337-339.
34.	石奇嵩. 腦電生物反饋療法聯合帕羅西汀治療焦慮癥效果分析. 吉林醫學, 2021, 42(5): 1153-1154.
35.	Fernández-Alvarez J, Grassi M, Colombo D, et al. Efficacy of bio- and neurofeedback for depression: a meta-analysis. Psychol Med, 2022, 52(2): 201-216.
36.	鄧江南, 葉鑫武, 趙飛飛. 腦電生物反饋治療對抑郁癥患者睡眠質量及自主神經功能的影響. 重慶醫學, 2025, 54(1): 127-131, 137.
37.	曾悅, 鄒先彪. 銀屑病紫外線治療新進展. 中國醫學前沿雜志(電子版), 2023, 15(5): 25-31.
38.	楊素玲. 311 nm 窄譜中波紫外線照射治療尋常性銀屑病的療效及安全性觀察. 臨床研究, 2023, 31(4): 104-107.
39.	Li Y, Cao Z, Guo J, et al. Assessment of efficacy and safety of UV-based therapy for psoriasis: a network meta-analysis of randomized controlled trials. Ann Med, 2022, 54(1): 159-169.
40.	Bouceiro Mendes R, Alpalh?o M, Filipe P. UVB phototherapy in the treatment of vitiligo: state of the art and clinical perspectives. Photodermatol Photoimmunol Photomed, 2022, 38(3): 215-223.
41.	曾蕊, 徐秀蓮. 窄譜中波紫外線聯合其他方法治療白癜風的研究進展. 中華皮膚科雜志, 2024, 57(1): 75-78.
42.	馬紅麗. 他克莫司軟膏聯合窄譜中波紫外線照射治療白癜風的臨床效果評價. 系統醫學, 2020, 5(1): 112-114.
43.	Chopra S, Morrissette K, Fan E, et al. Photobiomodulation and photodynamic therapy using red LED light in dermatology: a narrative review. Bratisl Med J, 2025, 126(9): 2041-2053.
44.	Zhang L, Yang Y, Wang B, et al. Modified red light 5-aminolevulinic acid photodynamic therapy versus low-dose isotretinoin therapy for moderate to severe acne vulgaris: a prospective, randomized, multicenter study. J Am Acad Dermatol, 2023, 89(6): 1141-1148.

1. 徐榮達, 張赫, 段思宇, 等. 脈沖電磁場對肌肉骨組織作用的研究進展. 中國矯形外科雜志, 2024, 32(3): 254-258.
2. 鄧葉龍, 孔令俊, 劉朝輝, 等. 脈沖電磁場對骨代謝的分子細胞學作用機制研究進展. 中國骨質疏松雜志, 2022, 28(2): 290-295.
3. Nishi Y, Ikuno K, Minamikawa Y, et al. Tailored transcutaneous electrical nerve stimulation improves dysesthesia in individuals with spinal cord injury: a randomized N-of-1 trial. J Spinal Cord Med, 2025, 17: 1-10.
4. 燕鐵斌, 姜貴云, 吳軍, 等. 物理治療學. 北京: 人民衛生出版社, 2018.
5. Yang X, Zhang X, Yin M, et al. Elastic compression stockings to prevent post-thrombotic syndrome in proximal deep venous thrombosis patients without thrombus removal. J Vasc Surg Venous Lymphat Disord, 2022, 10(2): 293-299.
6. Jenkins S, Cross A, Osman H, et al. Effectiveness of biofeedback on blood pressure in patients with hypertension: systematic review and meta-analysis. J Hum Hypertens, 2024, 38(10): 719-727.
7. 董銘杰, 薛瑞君, 徐紫晴, 等. 低頻重復經顱磁刺激治療顱腦損傷后陣發性交感神經亢進 27 例療效觀察. 中華航海醫學與高氣壓醫學雜志, 2022, 29(4): 521-524, 549.
8. Wang J, Li Z, Pan M, et al. Ultrasound-mediated blood-brain barrier opening: an effective drug delivery system for theranostics of brain diseases. Adv Drug Deliv Rev, 2022, 190: 114539.
9. Sanwal R, Joshi K, Ditmans M, et al. Ultrasound and microbubbles for targeted drug delivery to the lung endothelium in ARDS: cellular mechanisms and therapeutic opportunities. Biomedicines, 2021, 9(7): 803.
10. Li W, Li X, Kong Z, et al. Efficacy of low-intensity pulsed ultrasound in the treatment of COVID-19 pneumonia. Ultraschall Med, 2023, 44(6): e274-e283.
11. 任玲. 超短波治療重癥康復患者細菌性肺炎的隨機對照試驗. 成都: 四川大學, 2023.
12. 黃璽, 沈陽, 李小寒. 電針與促胃動力藥治療功能性便秘的系統評價. 針刺研究, 2020, 45(7): 592-598.
13. 蔣惠瑜, 周蔚, 明小紅, 等. 干擾電刺激八髎穴、大腸俞穴聯合莫沙必利治療糖尿病便秘患者療效觀察. 康復學報, 2021, 31(6): 501-507.
14. 何件根, 武亮. 超短波治療降低腦卒中患者下尿路感染發生率的臨床研究. 醫師在線, 2023, 13(7): 34-36.
15. 劉利杰, 陳鑫, 黃華偉, 等. 低能量體外沖擊波治療磷酸二酯酶-5 抑制劑無反應性勃起功能障礙療效研究. 中國男科學雜志, 2021, 35(2): 19-23.
16. Kaadan A, Salati S, Setti S, et al. Augmentation of deficient bone healing by pulsed electromagnetic fields-from mechanisms to clinical outcomes. Bioengineering (Basel), 2024, 11(12): 1223.
17. Masante B, Gabetti S, Silva JC, et al. Insights into bone and cartilage responses to pulsed electromagnetic field stimulation: a review with quantitative comparisons. Front Bioeng Biotechnol, 2025, 13: 1557572.
18. 蘇小強, 王向陽, 白晶晶. 低頻脈沖電磁療聯合唑來膦酸治療絕經后老年女性骨質疏松性椎體壓縮性骨折的臨床效果. 臨床醫學研究與實踐, 2022, 7(24): 1-4.
19. 夏駟捷, 廖琦. 低強度脈沖超聲治療骨折的系統回顧和薈萃分析. 中國組織工程研究, 2021, 25(12): 1944-1950.
20. Leppik L, Oliveira KMC, Bhavsar MB, et al. Electrical stimulation in bone tissue engineering treatments. Eur J Trauma Emerg Surg, 2020, 46(2): 231-244.
21. 朱璐, 吳文忠, 陳銘, 等. 電針對原發性骨質疏松癥患者運動功能的影響: 隨機對照研究. 中國針灸, 2022, 42(2): 145-149.
22. 許紅娣. 電腦中頻電療對肩周炎患者關節疼痛及功能恢復的影響. 現代診斷與治療, 2021, 32(14): 2308-2309.
23. 李孟忠, 張建國, 梁文杰, 等. 溫針電針腰三針治療寒濕型慢性腰肌勞損: 隨機對照試驗. 中國針灸, 2025, 45(10): 1421-1426.
24. 朱志恒, 趙仙麗, 丁道芳, 等. 肌內效貼治療膝骨關節炎的作用機制研究進展. 按摩與康復醫學, 2022, 13(17): 55-60.
25. 李兆寶, 黃明勇, 羅君. 肌內效貼結合玻璃酸鈉注射治療膝骨關節炎的療效研究. 中國康復, 2019, 34(8): 423-425.
26. El Melhat AM, Youssef ASA, Zebdawi MR, et al. Non-surgical approaches to the management of lumbar disc herniation associated with radiculopathy: a narrative review. J Clin Med, 2024, 13(4): 974.
27. 馬軍廷, 張振國, 袁燕, 等. 仰臥位手法牽引對神經根型頸椎病患者血清炎癥因子的影響. 分子診斷與治療雜志, 2021, 13(9): 1486-1489, 1493.
28. Roman N, Miclaus RS, Necula R, et al. Physiotherapy efficiency in post-stroke upper extremity spasticity: TENS vs. ultrasound vs. paraffin. In Vivo, 2023, 37(2): 916-923.
29. 謝偉想, 陳蜀, 譚育華, 等. 蠟療治療兒童痙攣型腦癱臨床療效的 Meta 分析. 中國兒童保健雜志, 2021, 29(8): 881-885, 890.
30. Ali S, Sun M, Khan MN, et al. Advances in sciatic nerve regeneration: a review of contemporary techniques. Regen Ther, 2025, 29: 563-574.
31. 陳易, 鄭曉, 李巖峰. 電針聯合口服甲鈷胺片治療 2 型糖尿病合并輕中度腕管綜合征臨床研究. 國際中醫中藥雜志, 2021, 43(3): 242-245.
32. 胡曉穎, 雷鴻雁, 馬珊珊, 等. 重復經顱磁刺激配合丁苯酞軟膠囊治療帕金森合并認知功能障礙患者的效果. 中國當代醫藥, 2023, 30(20): 46-49.
33. 張瑩, 徐文成, 陳秋妍, 等. 基于“生物全息論”探析多參數生物反饋干預治療廣泛性焦慮障礙的生物學機制. 國際精神病學雜志, 2025, 52(2): 337-339.
34. 石奇嵩. 腦電生物反饋療法聯合帕羅西汀治療焦慮癥效果分析. 吉林醫學, 2021, 42(5): 1153-1154.
35. Fernández-Alvarez J, Grassi M, Colombo D, et al. Efficacy of bio- and neurofeedback for depression: a meta-analysis. Psychol Med, 2022, 52(2): 201-216.
36. 鄧江南, 葉鑫武, 趙飛飛. 腦電生物反饋治療對抑郁癥患者睡眠質量及自主神經功能的影響. 重慶醫學, 2025, 54(1): 127-131, 137.
37. 曾悅, 鄒先彪. 銀屑病紫外線治療新進展. 中國醫學前沿雜志(電子版), 2023, 15(5): 25-31.
38. 楊素玲. 311 nm 窄譜中波紫外線照射治療尋常性銀屑病的療效及安全性觀察. 臨床研究, 2023, 31(4): 104-107.
39. Li Y, Cao Z, Guo J, et al. Assessment of efficacy and safety of UV-based therapy for psoriasis: a network meta-analysis of randomized controlled trials. Ann Med, 2022, 54(1): 159-169.
40. Bouceiro Mendes R, Alpalh?o M, Filipe P. UVB phototherapy in the treatment of vitiligo: state of the art and clinical perspectives. Photodermatol Photoimmunol Photomed, 2022, 38(3): 215-223.
41. 曾蕊, 徐秀蓮. 窄譜中波紫外線聯合其他方法治療白癜風的研究進展. 中華皮膚科雜志, 2024, 57(1): 75-78.
42. 馬紅麗. 他克莫司軟膏聯合窄譜中波紫外線照射治療白癜風的臨床效果評價. 系統醫學, 2020, 5(1): 112-114.
43. Chopra S, Morrissette K, Fan E, et al. Photobiomodulation and photodynamic therapy using red LED light in dermatology: a narrative review. Bratisl Med J, 2025, 126(9): 2041-2053.
44. Zhang L, Yang Y, Wang B, et al. Modified red light 5-aminolevulinic acid photodynamic therapy versus low-dose isotretinoin therapy for moderate to severe acne vulgaris: a prospective, randomized, multicenter study. J Am Acad Dermatol, 2023, 89(6): 1141-1148.

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Precise clinical application of physical agent therapy based on their “drug-like” mechanisms of action

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