Research progress on clinical application of left atrial appendage closure combined with intracardiac echocardiography in patients with atrial fibrillation_West China Medical Journal

Authors：

WANG Ping ¹ , ZHANG Yuan ¹ ,  JI Jun ^1,2

1. Department of Cardiovascular Medicine, Northern Jiangsu People’s Hospital Affiliated to Yangzhou University, Yangzhou, Jiangsu 225001, P. R. China;
2. Department of Cardiovascular Medicine, Northern Jiangsu People’s Hospital, Yangzhou, Jiangsu 225001, P. R. China;

Corresponding?author：

JI Jun, Email: jijun12008@163.com

Keywords：

Left atrial appendage closure; atrial fibrillation; stroke prevention; intracardiac echocardiography; transesophageal echocardiography

DOI：

10.7507/1002-0179.202510081

Video：

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Left atrial appendage closure (LAAC) serves as a non-pharmacological stroke prevention therapy for atrial fibrillation patients, suited for people with anticoagulation contraindications or high bleeding risks. Occluders Watchman, LAmbre and Amplatzer Cardiac Plug have received generational upgrades, with notably improved safety and clinical adaptability. For intraoperative image guidance, intracardiac echocardiography (ICE) surpasses transesophageal echocardiography (TEE) in image clarity, precision, tolerance and radiation management, and can partially replace TEE. Chinese clinical data validate the safety and effectiveness of ICE-guided LAAC, especially for seniors and patients with complex cardiac anatomy. Future technical optimization, systematic training and multi-technology integration will support more precise and extensive clinical promotion of LAAC.

Citation： WANG Ping, ZHANG Yuan, JI Jun. Research progress on clinical application of left atrial appendage closure combined with intracardiac echocardiography in patients with atrial fibrillation. West China Medical Journal, 2026, 41(8): 1368-1372. doi: 10.7507/1002-0179.202510081 Copy

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4. Richardson AC, Omar M, Velarde G, et al. Right atrial appendage thrombus in atrial fibrillation: a case report and review of the literature[J]. J Investig Med High Impact Case Rep, 2021, 9: 23247096211010048.
5. 許明雷. 心臟瓣膜手術同期行直視下改良雙極射頻消融術治療房顫的臨床研究[D]. 濟南: 山東大學, 2018.
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Research progress on clinical application of left atrial appendage closure combined with intracardiac echocardiography in patients with atrial fibrillation

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