Visual analysis of the correlation between obesity and neuroinflammation_West China Medical Journal

Authors：

ZHOU Ye ,  ZHAO Bei

School of Basic Medicine Sciences, Dali University, Dali, Yunnan 617000, P. R. China;

Corresponding?author：

ZHAO Bei, Email: zaozhui@163.com

Keywords：

Obesity; neuroinflammation; visual analysis

DOI：

10.7507/1002-0179.202207104

Video：

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Objective To summarize the current status and hotspots of research on obesity and neuroinflammation in the last decade through bibliometric analysis. Method Web of Science database was searched for English literature on obesity and neuroinflammation published between 2011 and 2021. The CiteSpace software was applied to analyze the number of publications, authors, institutions, countries and collaborations, and keywords in the field of obesity and neuroinflammation research.Results A total of 548 articles were included, and the number of articles had been increasing year by year. The top three countries in the field of obesity and neuroinflammation research were the United States, China, and Brazil. University of Toronto was the core research institution. Keywords formed 16 clusters, and there were a total of 15 emergent words.Conclusions Over the past decade, research on obesity and neuroinflammation has shown an upward trend. The research hotspots in the field of obesity and neuroinflammation mainly focus on insulin resistance, obesity, Alzheimer’s disease, high fat diet, inflammation, neuroinflammation, and other aspects. The prefrontal cortex and memory impairment are future hotspots.

Citation： ZHOU Ye, ZHAO Bei. Visual analysis of the correlation between obesity and neuroinflammation. West China Medical Journal, 2023, 38(4): 518-524. doi: 10.7507/1002-0179.202207104 Copy

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2.	Frühbeck G, Toplak H, Woodward E, et al. Obesity: the gateway to ill health - an EASO position statement on a rising public health, clinical and scientific challenge in Europe. Obes Facts, 2013, 6(2): 117-120.
3.	Rhea EM, Salameh TS, Logsdon AF, et al. Blood-brain barriers in obesity. AAPS J, 2017, 19(4): 921-930.
4.	Gómez-Apo E, Mondragón-Maya A, Ferrari-Díaz M, et al. Structural brain changes associated with overweight and obesity. J Obes, 2021, 2021: 6613385.
5.	Leng F, Edison P. Neuroinflammation and microglial activation in Alzheimer disease: where do we go from here?. Nat Rev Neurol, 2021, 17(3): 157-172.
6.	Van Dyken P, Lacoste B. Impact of metabolic syndrome on neuroinflammation and the blood-brain barrier. Front Neurosci, 2018, 12: 930.
7.	Karczewski J, Zielińska A, Staszewski R, et al. Obesity and the Brain. Int J Mol Sci, 2022, 23(11): 6145.
8.	邱均平, 沈恝諶, 宋艷輝. 近十年國內外計量經濟學研究進展與趨勢—基于 Citespace 的可視化對比研究. 現代情報, 2019, 39(2): 26-37.
9.	陳悅, 陳超美, 劉則淵, 等. CiteSpace 知識圖譜的方法論功能. 科學學研究, 2015, 33(2): 242-253.
10.	Liang C, Luo A, Zhong Z. Knowledge mapping of medication literacy study: a visualized analysis using CiteSpace. SAGE Open Med, 2018, 6: 2050312118800199.
11.	范楊陽, 王天芳, 董儉, 等. 2014 年至 2018 年國內中醫英譯研究的文獻計量與可視化分析. 中華中醫藥雜志, 2020, 35(6): 3094-3097.
12.	秦曉楠, 盧小麗, 武春友. 國內生態安全研究知識圖譜—基于 Citespace 的計量分析. 生態學報, 2014, 34(13): 3693-3703.
13.	Kang DH, Heo RW, Yi CO, et al. High-fat diet-induced obesity exacerbates kainic acid-induced hippocampal cell death. Bmc Neurosci, 2015, 16: 72.
14.	Nguyen JC, Killcross AS, Jenkins TA. Obesity and cognitive decline: role of inflammation and vascular changes. Front Neurosci, 2014, 8: 375.
15.	Alexaki VI. The impact of obesity on microglial function: immune, metabolic and endocrine perspectives. Cells, 2021, 10(7): 1584.
16.	Galea I. The blood-brain barrier in systemic infection and inflammation. Cell Mol Immunol, 2021, 18(11): 2489-2501.
17.	Cheng J, Dong Y, Ma J, et al. Microglial Calhm2 regulates neuroinflammation and contributes to Alzheimer’s disease pathology. Sci Adv, 2021, 7(35): eabe3600.
18.	Olsthoorn L, Vreeken D, Kiliaan AJ. Gut microbiome, inflammation, and cerebrovascular function: link between obesity and cognition. Front Neurosci, 2021, 15: 761456.
19.	Dalile B, Van Oudenhove L, Vervliet B, et al. The role of short-chain fatty acids in microbiota-gut-brain communication. Nat Rev Gastroenterol Hepatol, 2019, 16(8): 461-478.
20.	Lorena FB, do Nascimento BPP, Camargo ELRA, et al. Long-term obesity is associated with depression and neuroinflammation. Arch Endocrinol Metab, 2021, 65(5): 537-548.
21.	de Oliveira S, Feijó GDS, Neto J, et al. Zinc supplementation decreases obesity-related neuroinflammation and improves metabolic function and memory in rats. Obesity (Silver Spring), 2021, 29(1): 116-124.
22.	Lituma PJ, Woo E, O’Hara BF, et al. Altered synaptic connectivity and brain function in mice lacking microglial adapter protein Iba1. Proc Natl Acad Sci USA, 2021, 118(46): e2115539118.
23.	Forte N, Fernández-Rilo AC, Palomba L, et al. Obesity affects the microbiota-gut-brain axis and the regulation thereof by endocannabinoids and related mediators. Int J Mol Sci, 2020, 21(5): 1554.
24.	Arnoriaga-Rodríguez M, Mayneris-Perxachs J, Burokas A, et al. Obesity impairs short-term and working memory through gut microbial metabolism of aromatic amino acids. Cell Metab, 2020, 32(4): 548-560.e7.
25.	Zeng Q, Li D, He Y, et al. Discrepant gut microbiota markers for the classification of obesity-related metabolic abnormalities. Sci Rep, 2019, 9(1): 13424.

1. Lainez NM, Coss D. Obesity, neuroinflammation, and reproductive function. Endocrinology, 2019, 160(11): 2719-2736.
2. Frühbeck G, Toplak H, Woodward E, et al. Obesity: the gateway to ill health - an EASO position statement on a rising public health, clinical and scientific challenge in Europe. Obes Facts, 2013, 6(2): 117-120.
3. Rhea EM, Salameh TS, Logsdon AF, et al. Blood-brain barriers in obesity. AAPS J, 2017, 19(4): 921-930.
4. Gómez-Apo E, Mondragón-Maya A, Ferrari-Díaz M, et al. Structural brain changes associated with overweight and obesity. J Obes, 2021, 2021: 6613385.
5. Leng F, Edison P. Neuroinflammation and microglial activation in Alzheimer disease: where do we go from here?. Nat Rev Neurol, 2021, 17(3): 157-172.
6. Van Dyken P, Lacoste B. Impact of metabolic syndrome on neuroinflammation and the blood-brain barrier. Front Neurosci, 2018, 12: 930.
7. Karczewski J, Zielińska A, Staszewski R, et al. Obesity and the Brain. Int J Mol Sci, 2022, 23(11): 6145.
8. 邱均平, 沈恝諶, 宋艷輝. 近十年國內外計量經濟學研究進展與趨勢—基于 Citespace 的可視化對比研究. 現代情報, 2019, 39(2): 26-37.
9. 陳悅, 陳超美, 劉則淵, 等. CiteSpace 知識圖譜的方法論功能. 科學學研究, 2015, 33(2): 242-253.
10. Liang C, Luo A, Zhong Z. Knowledge mapping of medication literacy study: a visualized analysis using CiteSpace. SAGE Open Med, 2018, 6: 2050312118800199.
11. 范楊陽, 王天芳, 董儉, 等. 2014 年至 2018 年國內中醫英譯研究的文獻計量與可視化分析. 中華中醫藥雜志, 2020, 35(6): 3094-3097.
12. 秦曉楠, 盧小麗, 武春友. 國內生態安全研究知識圖譜—基于 Citespace 的計量分析. 生態學報, 2014, 34(13): 3693-3703.
13. Kang DH, Heo RW, Yi CO, et al. High-fat diet-induced obesity exacerbates kainic acid-induced hippocampal cell death. Bmc Neurosci, 2015, 16: 72.
14. Nguyen JC, Killcross AS, Jenkins TA. Obesity and cognitive decline: role of inflammation and vascular changes. Front Neurosci, 2014, 8: 375.
15. Alexaki VI. The impact of obesity on microglial function: immune, metabolic and endocrine perspectives. Cells, 2021, 10(7): 1584.
16. Galea I. The blood-brain barrier in systemic infection and inflammation. Cell Mol Immunol, 2021, 18(11): 2489-2501.
17. Cheng J, Dong Y, Ma J, et al. Microglial Calhm2 regulates neuroinflammation and contributes to Alzheimer’s disease pathology. Sci Adv, 2021, 7(35): eabe3600.
18. Olsthoorn L, Vreeken D, Kiliaan AJ. Gut microbiome, inflammation, and cerebrovascular function: link between obesity and cognition. Front Neurosci, 2021, 15: 761456.
19. Dalile B, Van Oudenhove L, Vervliet B, et al. The role of short-chain fatty acids in microbiota-gut-brain communication. Nat Rev Gastroenterol Hepatol, 2019, 16(8): 461-478.
20. Lorena FB, do Nascimento BPP, Camargo ELRA, et al. Long-term obesity is associated with depression and neuroinflammation. Arch Endocrinol Metab, 2021, 65(5): 537-548.
21. de Oliveira S, Feijó GDS, Neto J, et al. Zinc supplementation decreases obesity-related neuroinflammation and improves metabolic function and memory in rats. Obesity (Silver Spring), 2021, 29(1): 116-124.
22. Lituma PJ, Woo E, O’Hara BF, et al. Altered synaptic connectivity and brain function in mice lacking microglial adapter protein Iba1. Proc Natl Acad Sci USA, 2021, 118(46): e2115539118.
23. Forte N, Fernández-Rilo AC, Palomba L, et al. Obesity affects the microbiota-gut-brain axis and the regulation thereof by endocannabinoids and related mediators. Int J Mol Sci, 2020, 21(5): 1554.
24. Arnoriaga-Rodríguez M, Mayneris-Perxachs J, Burokas A, et al. Obesity impairs short-term and working memory through gut microbial metabolism of aromatic amino acids. Cell Metab, 2020, 32(4): 548-560.e7.
25. Zeng Q, Li D, He Y, et al. Discrepant gut microbiota markers for the classification of obesity-related metabolic abnormalities. Sci Rep, 2019, 9(1): 13424.

West China Medical Journal

Visual analysis of the correlation between obesity and neuroinflammation

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