Comparison of potassium supplement with infusion pump and traditional potassium supplement in continuous renal replacement therapy_West China Medical Journal

Authors：

 CHEN Zhiwen , TANG Xiaojuan , WANG Beibei , ZHANG Sheng , WEI Tiantian , DAI Mingjin

Department of Nephrology, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, P. R. China;

Corresponding?author：

CHEN Zhiwen, Email: kiyuhot@163.com

Keywords：

Continuous renal replacement therapy; Infusion pump; Potassium chloride

DOI：

10.7507/1002-0179.201807008

Video：

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Objective To explore the feasibility and effect of infusion pump potassium supplementation in continuous renal replacement therapy (CRRT). Methods Patients who underwent CRRT were randomly divided into infusion pump group and traditional way group between March and May 2018. In infusion pump group, 10% potassium chloride was supplemented with infusion pump. In traditional way group, 10% potassium chloride was supplemented in the traditional way, which meant adding potassium in the replacement solution. The peripheral blood potassium level, the potassium well-controlled rate, the incidence of adverse events, the average frequency of replacement liquid bags change, the average pump stopping time, and the delivery dose and potassium supplement dose between the two groups were compared. Results A total of 60 patients were randomly divided into two groups, with 30 cases in each group. The infusion pump group was treated with an average of 6.90 mL/h potassium supplement dose by infusion pump, and in traditional way group, potassium was added to the replacement solution by an average of 9.29 mL/h; there were significant differences between the two groups (P<0.05). When compared with traditional way group, there was no significant differences (P>0.05) in the peripheral blood potassium level and the potassium well-controlled rate of the patients at 0, 2, 8, 12 and 24 hours after CRRT (P>0.05). As for the adverse events rate, average frequency of replacement liquid bags change, average pump stopping time, and potassium supplement dose, there were significant differences between the two groups (P<0.05). Conclusions The application of infusion pump to supply potassium in CRRT is feasible and safe, and is superior to the traditional potassium supplement method. It could be further applied in clinical practice.

Citation： CHEN Zhiwen, TANG Xiaojuan, WANG Beibei, ZHANG Sheng, WEI Tiantian, DAI Mingjin. Comparison of potassium supplement with infusion pump and traditional potassium supplement in continuous renal replacement therapy. West China Medical Journal, 2018, 33(7): 856-859. doi: 10.7507/1002-0179.201807008 Copy

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13.	Uijtendaal EV, Zwart-van Rijkom JE, van Solinge WW, et al. Frequency of laboratory measurement and hyperkalaemia in hospitalised patients using serum potassium concentration increasing drugs. Eur J Clin Pharmacol, 2011, 67(9): 933-940.
14.	王艷, 曹積慧. 鎖骨下靜脈微量泵高濃度補鉀的療效觀察. 中國醫藥指南, 2016, 34(14): 152-153.
15.	鄧巖. 靜脈注射高濃度氯化鉀搶救嚴重低血鉀一例. 中外醫療, 2010(32): 83.
16.	張利娟, 黃金美, 費忠英. 微量泵注射高濃度氯化鉀治療嚴重低鉀血癥患者的護理進展. 當代護士: 下旬刊, 2014, 10(3): 7-9.

1. 付平. 連續性腎臟替代治療. 北京: 人民衛生出版社, 2016: 3.
2. 陳香美. 血液凈化標準操作規程 2010 版. 北京: 人民軍醫出版社, 2010: 47, 68-69.
3. 蔡吉, 趙慧華, 張育紅, 等. 微量泵輸注高濃度氯化鉀臨床應用的護理進展. 護理學雜志, 2012, 27(22): 93-96.
4. RENAL Replacement Therapy Study Investigators, Bellomo R, Cass A, et al. Intensity of continuous renal-replacement therapy in critically ill patients. N Engl J Med, 2009, 361(17): 1627-1638.
5. Kidney disease: improving global outcomes (KDIGO) acute kidney injury work group. KDIGO clinical practice guideline for acute kidney injury. Kidney Int Suppl, 2012, 2(1): 1-138.
6. 黃家駟, 吳階平. 外科學 (上冊). 北京: 人民衛生出版社, 1982: 150-151.
7. 鄭惠鵬, 史偉. 微泵靜脈注射氯化鉀溶液搶救嚴重低鉀血癥 1 例. 廣東醫學, 2005, 26(1): 119.
8. 王海龍, 張亞會, 唐莉杰. 高濃度氯化鉀微量泵注射在重度低鉀血癥中的應用. 中國醫藥指南, 2011, 9(13): 122-123.
9. 劉輝, 楊曉華, 王蘇華. 微量泵高濃度泵鉀在心臟瓣膜置換術后早期的應用. 西部醫學, 2010, 22(12): 2348-2349.
10. 陳雪芳. 10 例應用微量泵外周靜脈高濃度補鉀的臨床觀察與護理. 全科護理, 2009, 7(4): 895-896.
11. 陸再英, 鐘南山. 內科學. 7 版. 北京: 人民衛生出版社, 2008: 689-691.
12. Bundgaard H, Kjeldsen K. Potassium depletion increases potassium clearance capacity in skeletal muscles in vivo during acute repletion. Am J Physiol Cell Physiol, 2002, 283(4): C1163-C1170.
13. Uijtendaal EV, Zwart-van Rijkom JE, van Solinge WW, et al. Frequency of laboratory measurement and hyperkalaemia in hospitalised patients using serum potassium concentration increasing drugs. Eur J Clin Pharmacol, 2011, 67(9): 933-940.
14. 王艷, 曹積慧. 鎖骨下靜脈微量泵高濃度補鉀的療效觀察. 中國醫藥指南, 2016, 34(14): 152-153.
15. 鄧巖. 靜脈注射高濃度氯化鉀搶救嚴重低血鉀一例. 中外醫療, 2010(32): 83.
16. 張利娟, 黃金美, 費忠英. 微量泵注射高濃度氯化鉀治療嚴重低鉀血癥患者的護理進展. 當代護士: 下旬刊, 2014, 10(3): 7-9.

West China Medical Journal

Comparison of potassium supplement with infusion pump and traditional potassium supplement in continuous renal replacement therapy

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