Misdiagnosis and Prognosis of Metastatic Ovarian Carcinoma from Gastrointestinal Tract_West China Medical Journal

Authors：

 YeXin ¹ ,  LiYi ²

1. Department of Gynecology and Obstetrics, Medical Center of Dujiangyan, Dujiangyan, Sichuan 611830, P. R. China;
2. Department of Gastrointestinal Surgery, Affiliated 363 Hospital, Southwest Medical University, Chengdu, Sichuan 610041, P. R. China;

Corresponding?author：

LiYi, Email: 20980435@qq.com

Keywords：

Gastrointestinal metastasis; Ovarian cancer; Misdiagnosis; Prognosis

DOI：

10.7507/1002-0179.201600379

Video：

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Objective To analyze the reasons for misdiagnosis of gastrointestinal metastatic ovarian cancer, in order to increase the rate of correct diagnosis and treatment, and to investigate the prognostic factors. Methods We retrospectively analyzed the clinical features, pathological features and prognostic factors of 43 cases of metastatic ovarian carcinoma from gastrointestinal tract treated between 2004 and 2014. Results Gastrointestinal metastatic ovarian cancer was characterized by the diversity of clinical manifestations and lack of specific symptoms. The common initial symptom was pelvic mass, frequently accompanied with gastrointestinal symptoms of ascites, anemia or weight loss, abdominal pain, bloating, gastrointestinal obstruction and bleeding. Signs and symptoms of primary and secondary tumor sites often coexisted with each other, leading to misdiagnosis. Univariate analysis showed that primary site, histological type, surgical treatment, the residual tumor debulking size, lymph node metastasis, tumor invasion and standard chemotherapy had significant impacts on the prognosis (P < 0.05). Conclusions Gastrointestinal metastatic ovarian cancer occurs in premenopausal women, often with ascites, abdominal pelvic masses as the first symptom. Primary tumor site is often ignored, and the initial correct diagnosis rate is low. Metastasis from stomach cancer is the most common, followed by colorectal cancer and esophageal cancer. Prognosis is correlated with the primary site, histological type, degree of differentiation, depth of invasion, lymph node metastasis and other factors. Radical surgery and chemotherapy can improve survival.

Citation： YeXin, LiYi. Misdiagnosis and Prognosis of Metastatic Ovarian Carcinoma from Gastrointestinal Tract. West China Medical Journal, 2016, 31(8): 1394-1397. doi: 10.7507/1002-0179.201600379 Copy

1.	Yook JH, Oh ST, Kim BS. Clinical prognostic factors for ovarian metastasis in women with gastric cancer[J]. Hepatogastroenterology, 2007, 54(75):955-959.
2.	Moore RG, Chung M, Granai CO, et al. Incidence of metastasis to the ovaries from nongenital tract primary tumors[J]. Gynecol Oncol, 2004, 93(1):87-91.
3.	湯釗猷.現代腫瘤學[M]. 2版.上海:上海醫科大學出版社, 2000.
4.	Yada-Hashimoto N, Yamamoto T, Kamiura S, et al. Metastatic ovarian tumors:a review of 64 cases[J]. Gynecol Oncol, 2003, 89(2):314-317.
5.	Taylor AE, Nicolson VM, Cunningham D. Ovarian metastases from primary gastrointestinal malignancies:the Royal Marsden Hospital experience and implications for adjuvant treatment[J]. Br J Cancer, 1995, 71(1):92-96.
6.	吳堅文, 杜志強, 李丹, 等.洛鉑聯合多西他賽治療復發轉移性卵巢癌的療效[J].廣東醫學, 2013, 34(6):944-946.
7.	張淑芳, 周亭芳, 付挺.洛鉑聯合多西他賽治療復發轉移性卵巢癌的臨床效果[J].中外醫學研究, 2014, 12(2):26-27.
8.	馬或, 李藝, 崔恒.卵巢癌的新輔助化療[J].實用婦產科雜志, 2013, 29(4):244-246.
9.	Cheong JH, Hyung WJ, Chen J, et al. Survival benefit of metastasectomy for Krukenberg tumors from gastric cancer[J]. Gynecol Oncol, 2004, 94(2):477-482.
10.	Page LA, Rubia K, Deeley Q, et al. A functional magnetic resonance imaging study of inhibitory control in obsessive-compulsive disorder[J]. Psychiatry Res, 2009, 174(3):202-209.
11.	王純正, 徐智章.超聲診斷學[M].北京:人民衛生出版社, 2000:411.
12.	郭志鵬.胃癌致雙卵巢轉移癌1例[J].臨床合理用藥雜志, 2014, 7(8):161.
13.	康錚, 沈文榮, 張蘭芳.轉移性卵巢癌的CT診斷[J].實用臨床醫藥雜志, 2009, 13(21):150-151, 153.
14.	Kim HK, Heo DS, Bang YJ, et al. Prognostic factors of Krukenberg's tumor[J]. Gynecol Oncol, 2001, 82(1):105-109.
15.	Ayhan A, Guvenal T, Salman MC, et al. The role of cytoreductive surgery in nongenital cancers metastatic to the ovaries[J]. Gynecol Oncol, 2005, 98(2):235-241.
16.	Kiyokawa T, Young RH, Scully RE. Krukenberg tumors of the ovary:a clinicopathologic analysis of 120 cases with emphasis on their variable pathologic manifestations[J]. Am J Surg Pathol, 2006, 30(3):277-299.

1. Yook JH, Oh ST, Kim BS. Clinical prognostic factors for ovarian metastasis in women with gastric cancer[J]. Hepatogastroenterology, 2007, 54(75):955-959.
2. Moore RG, Chung M, Granai CO, et al. Incidence of metastasis to the ovaries from nongenital tract primary tumors[J]. Gynecol Oncol, 2004, 93(1):87-91.
3. 湯釗猷.現代腫瘤學[M]. 2版.上海:上海醫科大學出版社, 2000.
4. Yada-Hashimoto N, Yamamoto T, Kamiura S, et al. Metastatic ovarian tumors:a review of 64 cases[J]. Gynecol Oncol, 2003, 89(2):314-317.
5. Taylor AE, Nicolson VM, Cunningham D. Ovarian metastases from primary gastrointestinal malignancies:the Royal Marsden Hospital experience and implications for adjuvant treatment[J]. Br J Cancer, 1995, 71(1):92-96.
6. 吳堅文, 杜志強, 李丹, 等.洛鉑聯合多西他賽治療復發轉移性卵巢癌的療效[J].廣東醫學, 2013, 34(6):944-946.
7. 張淑芳, 周亭芳, 付挺.洛鉑聯合多西他賽治療復發轉移性卵巢癌的臨床效果[J].中外醫學研究, 2014, 12(2):26-27.
8. 馬或, 李藝, 崔恒.卵巢癌的新輔助化療[J].實用婦產科雜志, 2013, 29(4):244-246.
9. Cheong JH, Hyung WJ, Chen J, et al. Survival benefit of metastasectomy for Krukenberg tumors from gastric cancer[J]. Gynecol Oncol, 2004, 94(2):477-482.
10. Page LA, Rubia K, Deeley Q, et al. A functional magnetic resonance imaging study of inhibitory control in obsessive-compulsive disorder[J]. Psychiatry Res, 2009, 174(3):202-209.
11. 王純正, 徐智章.超聲診斷學[M].北京:人民衛生出版社, 2000:411.
12. 郭志鵬.胃癌致雙卵巢轉移癌1例[J].臨床合理用藥雜志, 2014, 7(8):161.
13. 康錚, 沈文榮, 張蘭芳.轉移性卵巢癌的CT診斷[J].實用臨床醫藥雜志, 2009, 13(21):150-151, 153.
14. Kim HK, Heo DS, Bang YJ, et al. Prognostic factors of Krukenberg's tumor[J]. Gynecol Oncol, 2001, 82(1):105-109.
15. Ayhan A, Guvenal T, Salman MC, et al. The role of cytoreductive surgery in nongenital cancers metastatic to the ovaries[J]. Gynecol Oncol, 2005, 98(2):235-241.
16. Kiyokawa T, Young RH, Scully RE. Krukenberg tumors of the ovary:a clinicopathologic analysis of 120 cases with emphasis on their variable pathologic manifestations[J]. Am J Surg Pathol, 2006, 30(3):277-299.

West China Medical Journal

Misdiagnosis and Prognosis of Metastatic Ovarian Carcinoma from Gastrointestinal Tract

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