Effect of Fufang Xueshuantong Combined with Laser Photocoagulation <i>versus</i> Laser Photocoagulation Along for the Treatment of Diabetic Retinopathy: A Meta-analysis_West China Medical Journal

Authors：

 CHENYong-zhi , MOYuan-wai , LIChun-bei

Pharmaceutical Department, the Central Hospital of Panzhihua City, Panzhihua, Sichuan 617000. P. R. China;

Corresponding?author：

Keywords：

Fufang Xueshuantong; Laser photocoagulation; Diabetic Retinopathy; Meta-analysis

DOI：

10.7507/1002-0179.20150475

Video：

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Objective To evaluate the effects of Fufang Xueshuantong combined with laser photocoagulation versus laser photocoagulation alone in the treatment of diabetic retinopathy (DR). Method The Web of Science, Medline, Embase, the Cochrane Library, China Biology Medicine disc, China National Knowledge Infrastructure, VIP and Wanfang databases were searched from their establishment until June 2015. We used the method recommended by the Cochrane Collaboration to perform a meta-analysis of randomized controlled trails. RevMan 5.2 software was used for the analysis. Results Eight studies were included. The results of Meta-analysis demonstrated that Fufang Xueshuantong combined with laser photocoagulation was superior to laser photocoagulation alone in the effective rate of visual acuity[RR=1.19, 95%CI (1.12, 1.26), P<0.000 01], fundus[RR=1.34, 95%CI (1.18, 1.52), P<0.000 01], and elimination rate of macular edema[RR=1.29,95%CI(1.09,1.54),P=0.004]. Conclusions Fufang Xueshuantong combined with laser photocoagulation is effective for DR. However, due to the limited quantity and quality of the included studies, the results suggest that larger-scale trials are needed.

Citation： CHENYong-zhi, MOYuan-wai, LIChun-bei. Effect of Fufang Xueshuantong Combined with Laser Photocoagulation versus Laser Photocoagulation Along for the Treatment of Diabetic Retinopathy: A Meta-analysis. West China Medical Journal, 2015, 30(9): 1666-1670. doi: 10.7507/1002-0179.20150475 Copy

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1. 王倩倩, 于珮, 周賽君, 等. 糖尿病視網膜病變發病機制的研究進展[J]. 中華臨床醫師雜志:電子版, 2012, 6(3):685-687.
2. Neubauer AS, Ulbig MW. Laser treatment in diabetic retinopmhy[J]. Ophthalmologica, 2007, 221(2):95-102.
3. 許國忠, 楊蒞, 諸力偉. 復方血栓通膠囊聯合激光治療糖尿病視網膜病變療效觀察[J]. 浙江中西醫結合雜志, 2013, 23(10):821-823.
4. Higgins JPT, Altman DG. Cochrane handbook for systematic reviews of interventions Version 5.1.0 (updated March 2011)[EB/OL]. The Cochrane Collaboration, 2011[2013-04-01]. http://www.cochrane-handbook.org.
5. 鄭小燕, 潘曉霞. 復方血栓通膠囊聯合激光治療糖尿病視網膜病變的療效觀察[J]. 山西職工醫學院學報, 2012, 22(5):14-16.
6. 袁超英, 曾偉清. 局部光凝聯合復方血栓通治療對糖尿病視網膜內微血管異常的影響[J]. 臨床醫學工程, 2012, 19(6):913-914.
7. 彭志華, 吳嵐, 金小琴. 全視網膜光凝術聯合復方血栓通膠囊治療糖尿病視網膜病變的臨床觀察[J]. 湖北中醫藥大學學報, 2012, 14(5):54-55.
8. 樓繼先, 曹永葆, 徐潔慧, 等. 激光光凝術聯合復方血栓通膠囊治療糖尿病視網膜病變[J]. 浙江中西醫結合雜志, 2011, 21(6):419-420.
9. 王順, 艾明, 賀濤. 多波長激光聯合復方血栓通膠囊治療糖尿病視網膜病變臨床療效觀察[J]. 臨床眼科雜志, 2009, 17(3):213-215.
10. 林慧, 張鄧民, 衡昆山, 等. 光凝聯合復方血栓通膠囊治療糖尿病性視網膜病變臨床觀察[J]. 山東醫藥, 2009, 49(40):74-75.
11. 郭翠玲, 趙仲平, 湯愛燦, 等. 激光聯合復方血栓通膠囊治療糖尿病視網膜病變合并黃斑水腫的療效觀察[J]. 廣東醫學, 2009, 30(2):295-296.
12. Resnikoff S, Pascolini D, Etya'ale D, et al. Global data on visual impairment in the year 2002[J]. Bull World Health Organ, 2004, 82(11):844-851.
13. Park K, Chen Y, Hu Y, et al. Nanoparticle-mediated expression of an angiogenic inhibitor ameliorates ischemia-induced retinal neovascularization and diabetes-induced retinal vascular leakage[J]. Diabetes, 2009, 58(8):1902-1913.
14. 賈俊, 何媛, 劉慧峰, 等. 玻璃體切除聯合視網膜光凝治療增生性糖尿病視網膜病變[J]. 國際眼科雜志, 2014, 14(5):866-867.
15. 符敏, 吳偉, 唐羅生, 等. 糖尿病視網膜病變全視網膜光凝術后玻璃體視網膜界面的變化[J]. 眼科新進展, 2014, 34(11):1038-1042.
16. 王禹燕, 劉映霞, 麥少云, 等. 復方血栓通對NPDR激光光凝術后的視網膜血流動力學影響[J]. 國際眼科雜志, 2014, 14(7):1327-1328.
17. 沈國紅. 復方血栓通膠囊治療糖尿病視網膜病變的系統分析[J]. 中國中醫藥科技, 2014, 21(5):591-593.
18. 劉林平, 吳伯樂, 葉鋅銘, 等. 視網膜激光光凝聯合復方血栓通膠囊治療缺血型視網膜靜脈阻塞臨床觀察[J]. 浙江中西醫結合雜志, 2015, 25(1):67-69.

West China Medical Journal

Effect of Fufang Xueshuantong Combined with Laser Photocoagulation versus Laser Photocoagulation Along for the Treatment of Diabetic Retinopathy: A Meta-analysis

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