醋酸甲地孕酮在腫瘤化學療法患者中的應用及護理_West China Medical Journal

Authors：

 袁靈 ,  李秋 , 汪秀云

四川大學華西醫院腹部腫瘤科（成都 610041）;

Corresponding?author：

李秋, Email: fbqiu9@163.com

Keywords：

醋酸甲地孕酮; 抑制; 惡心嘔吐; 效果

DOI：

10.7507/1002-0179.20150158

Video：

Export PDF Favorites Scan Get Citation

Abstract Full text Figures/Tables Video References Cited by

目的觀察醋酸甲地孕酮（MA）對腫瘤患者化學療法（化療）期間惡心、嘔吐癥狀的抑制效果及不良反應。方法采用前瞻性、自身前后對照研究，將2013年3月－9月入院的60例化療腫瘤患者隨機分為A、B兩組。每組30例。A組在第1周期化療前2 d開始口服MA，160 mg/d，連續口服5 d；托烷司瓊5 mg/d，化療前30 min靜脈滴注，化療第1～3天；第2周期單用托烷司瓊。B組在第2周期口服MA+靜脈滴注托烷司瓊，第1周期單用托烷司瓊，余同前。化療結束后比較用MA和不用MA時的惡心、嘔吐發生率和程度，以及便秘、血栓、面色潮紅、陰道出血、血糖升高及水鈉潴留等不良反應發生率。結果患者用MA時惡心、嘔吐發生率較不用MA時明顯降低（P＜0.05），惡心、嘔吐程度也較不用MA時減輕（P＜0.05）。用MA和不用MA的便秘發生率比較，差異無統計學意義（P＞0.05）。兩組均未見血栓、面色潮紅、陰道出血、血糖升高及水鈉潴等不良反應。結論與不使用MA比較，腫瘤患者使用MA能明顯減輕化療引起的惡心、嘔吐反應，且不增加其他不良反應發生率。

Citation： 袁靈, 李秋, 汪秀云. 醋酸甲地孕酮在腫瘤化學療法患者中的應用及護理. West China Medical Journal, 2015, 30(3): 548-550. doi: 10.7507/1002-0179.20150158 Copy

1.	Lohr L. Chemotherapy-induced nausea and vomiting[J]. Cancer J, 2008, 14(2):85-93.
2.	崔慧娟. 醋酸甲地孕酮在晚期腫瘤治療中的應用進展[J]. 國外醫學:腫瘤學分冊, 2001, 28(6):473-474.
3.	Navari RM, Brenner MC. Treatment of cancer-related anorexia with olanzapine and megestrol acetate:a randomized trial[J]. Support Care Cancer, 2010, 18(8):951-956.
4.	Passalacqua R, Cocconi G, Caminiti C, et al. Double-blind, multicenter, randomized trial to compare the effect of two doses of adrenocorticotropic hormone versus placebo in controlling delayed emesis after high-dose cisplatin in adult patients with cancer[J]. J Clin Oncol, 1997, 15(6):2467-2473.
5.	Ulutin HC, Arpaci F, Pak Y. Megestrol acetate for cachexia and anorexia in advanced non-small cell lung cancer:a randomized study comparing two different doses[J]. Tumori, 2002, 88(4):277-280.
6.	劉曉聯, 裴顯俊, 靳曉玉. 化療引起疲勞的癌癥患者的護理[J]. 國外醫學:護理分冊, 2000, 19(8):359-360.
7.	南克俊, 魏永長, 李春麗, 等. 甲地孕酮改善晚期惡性腫瘤患者生活質量[J]. 第四軍醫大學學報, 2002, 23(4):350.
8.	Mantovani G, Macciò A, Esu S, et al. Evidence that cisplatin induces serotonin release from human peripheral blood mononuclear cells and that methylprednisolone inhibits this effect[J]. Eur J Cancer, 1996, 32A(11):1983-1985.
9.	Ho CM, Ho ST, Wang JJ, et al. Dexamethasone has a central antiemetic mechanism in decerebrated cats[J]. Anesth Analg, 2004, 99(3):734-739.
10.	Laviano A, Meguid MM, Rossi-Fanelli F. Cancer anorexia:clinical implications, pathogenesis, and therapeutic strategies[J]. Lancet Oncol, 2003, 4(11):686-694.

1. Lohr L. Chemotherapy-induced nausea and vomiting[J]. Cancer J, 2008, 14(2):85-93.
2. 崔慧娟. 醋酸甲地孕酮在晚期腫瘤治療中的應用進展[J]. 國外醫學:腫瘤學分冊, 2001, 28(6):473-474.
3. Navari RM, Brenner MC. Treatment of cancer-related anorexia with olanzapine and megestrol acetate:a randomized trial[J]. Support Care Cancer, 2010, 18(8):951-956.
4. Passalacqua R, Cocconi G, Caminiti C, et al. Double-blind, multicenter, randomized trial to compare the effect of two doses of adrenocorticotropic hormone versus placebo in controlling delayed emesis after high-dose cisplatin in adult patients with cancer[J]. J Clin Oncol, 1997, 15(6):2467-2473.
5. Ulutin HC, Arpaci F, Pak Y. Megestrol acetate for cachexia and anorexia in advanced non-small cell lung cancer:a randomized study comparing two different doses[J]. Tumori, 2002, 88(4):277-280.
6. 劉曉聯, 裴顯俊, 靳曉玉. 化療引起疲勞的癌癥患者的護理[J]. 國外醫學:護理分冊, 2000, 19(8):359-360.
7. 南克俊, 魏永長, 李春麗, 等. 甲地孕酮改善晚期惡性腫瘤患者生活質量[J]. 第四軍醫大學學報, 2002, 23(4):350.
8. Mantovani G, Macciò A, Esu S, et al. Evidence that cisplatin induces serotonin release from human peripheral blood mononuclear cells and that methylprednisolone inhibits this effect[J]. Eur J Cancer, 1996, 32A(11):1983-1985.
9. Ho CM, Ho ST, Wang JJ, et al. Dexamethasone has a central antiemetic mechanism in decerebrated cats[J]. Anesth Analg, 2004, 99(3):734-739.
10. Laviano A, Meguid MM, Rossi-Fanelli F. Cancer anorexia:clinical implications, pathogenesis, and therapeutic strategies[J]. Lancet Oncol, 2003, 4(11):686-694.

West China Medical Journal

醋酸甲地孕酮在腫瘤化學療法患者中的應用及護理

Abstract Full text Figures/Tables Video References Cited by

Previous Article

Next Article

Format

Content