The Influence of Paroxetine on Blood Sugar and Endocrine of Pre-diabetes Patients Associated with Anxiety and Depression_West China Medical Journal

Authors：

 FUXiao-qian ¹ , DONGZai-quan ¹ , LIXi-rong ² , ZHANGLan ¹ , TANGLei ³ , ZHANGXu ¹ , ZHANGYao-yin ¹ , JIANGFu-gui ¹ , LIJia-qi ⁴ , YUYe-rong ⁴ ,  SUNXue-li ¹

1. Mental Health Center, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, P. R. China;
2. Department of Psychiatry, the First Affiliated Hospital of Chongqing Medical University, Chongqing 400000, P. R. China;
3. Affiliated Hospital of North Sichuan Medical College, Nanchong, Sichuan 637000, P. R. China;
4. Department of Endocrinology, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, P. R. China;

Corresponding?author：

SUNXue-li, Email: sunxueli58@163.com

Keywords：

Pre-diabetes; Anxiety; Depression; Paroxetine; Hypothalamic-pituitary-adrenal axis

DOI：

10.7507/1002-0179.20140202

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Objective To explore the association between paroxetine (Seroxat) and level of blood sugar and endocrine hormones in pre-diabetes patients with anxiety and depression. Methods Fifty-four pre-diabetes patients with anxiety and depression diagnosed from January 2010 to December 2012 were recruited. The self-rating anxiety scale (SAS) and self-rating depression scale (SDS) were used to assess depression and anxiety. All the patients were treated by paroxetine. The glucose tolerance test (OGTT), ACTH and cortisol were tested in patients at baseline and within 24 weeks. Results After 24 weeks' treatment, the level of anxiety and depression as well as the OGTT 0.5 h (0.5 h PG), OGTT 1 h (1 h PG), OGTT 2 h (2 h PG), glycated hemoglobin (HbA1c), adrenocorticotropic hormone (ACTH) and cortisol were significantly decreased (P<0.05 or P<0.01). The glycated HbA1c had a positive correlation with adrenocorticotropic hormone (ACTH) and cortisol (F). Before and after treatment, the reduced rate of ACTH and reduced rate of cortisol respectively exhibited a positive correlation with the reduced rate of HbA1c, reduced rate of SAS and reduced rate of SDS. Conclusion Anti-anxiety depression treatment can lower blood sugar level in pre-diabetes patients with anxiety and depression significantly, which may be related to the activity of HPA axis.

Citation： FUXiao-qian, DONGZai-quan, LIXi-rong, ZHANGLan, TANGLei, ZHANGXu, ZHANGYao-yin, JIANGFu-gui, LIJia-qi, YUYe-rong, SUNXue-li. The Influence of Paroxetine on Blood Sugar and Endocrine of Pre-diabetes Patients Associated with Anxiety and Depression. West China Medical Journal, 2014, 29(4): 669-671. doi: 10.7507/1002-0179.20140202 Copy

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11.	仲愛芳, 王曉輝, 何益民, 等. 共患糖尿病的抑郁癥患者皮質醇分泌節律的研究[J]. 東南國防醫藥, 2011, 13(2):140-142.
12.	Egede LE, Osborn CY. Role of motivation in the relationship between depression, self-care, and glycemic control in adults with type 2 diabetes[J]. Diabetes Educ, 2010, 36(2):276-283.
13.	林東源, 劉志梅, 李劍軍, 等. 2型糖尿病60例下丘腦-垂體-腎上腺軸功能的變化[J]. 內科, 2009, 4(2):235-237.
14.	仲愛芳, 王曉輝, 何益民, 等. 共患糖尿病的抑郁癥患者皮質醇分泌節律的對照研究[J]. 實驗與檢驗醫學, 2010, 28(6):552-554.
15.	唐香花, 王桂玉, 田汝康, 等. 帕羅西汀聯合降糖藥物治療2型糖尿病療效觀察[J]. 國際醫藥衛生導報, 2012, 18(9):1253-1255.
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1. Buysschaert M, Bergman M. Definition of prediabetes[J]. Med Clin North Am, 2011, 95(2):289-297.
2. Aroda VR, Ratner R. Approach to the patient with prediabetes[J]. J Clin Endocrinol Metab, 2008, 93(9):3259-3265.
3. Eriksson AK, Ekbom A, Granath F, et al. Psychological distress and risk of pre-diabetes and type 2 diabetes in a prospective study of Swedish middle-aged men and women[J]. Diabet Med, 2008, 25(7):834-842.
4. 查松柏, 鐘志廷. 社區老年糖耐量異常患者180例心理健康狀態的調查[J]. 中華全科醫師雜志, 2006, 5(10):634-635.
5. 高金姣, 蔡建麗, 楊丹. 對糖耐量減退病人早期護理干預的研究[J]. 護理管理雜志, 2006, 6(7):5-6, 9.
6. Kyrios M, Moore SM, Hackworth N, et al. The influence of depression and anxiety on outcomes after an intervention for prediabetes[J]. Med J Aust, 2009, 190(7 Suppl):S81-S85.
7. Markowitz SM, Gonzalez JS, Wilkinson JL, et al. A review of treating depression in diabetes:emerging findings[J]. Psychosomatics, 2011, 52(1):1-18.
8. 周雪紅, 趙彥民, 楊波, 等. 糖尿病患者抗抑郁、抗焦慮治療血糖水平變化分析[J]. 中國現代藥物應用, 2011, 5(18):45-46.
9. 任向東, 王科, 于建成. 帕羅西汀治療2型糖尿病并發焦慮抑郁癥的臨床觀察[J]. 臨床和實驗醫學雜志, 2011, 10(22):1742-1743.
10. 李玲, 倪冬梅. 抗焦慮和抗抑郁治療對2型糖尿病患者血糖水平的影響[J]. 基礎醫學與臨床, 2011, 31(8):919-921.
11. 仲愛芳, 王曉輝, 何益民, 等. 共患糖尿病的抑郁癥患者皮質醇分泌節律的研究[J]. 東南國防醫藥, 2011, 13(2):140-142.
12. Egede LE, Osborn CY. Role of motivation in the relationship between depression, self-care, and glycemic control in adults with type 2 diabetes[J]. Diabetes Educ, 2010, 36(2):276-283.
13. 林東源, 劉志梅, 李劍軍, 等. 2型糖尿病60例下丘腦-垂體-腎上腺軸功能的變化[J]. 內科, 2009, 4(2):235-237.
14. 仲愛芳, 王曉輝, 何益民, 等. 共患糖尿病的抑郁癥患者皮質醇分泌節律的對照研究[J]. 實驗與檢驗醫學, 2010, 28(6):552-554.
15. 唐香花, 王桂玉, 田汝康, 等. 帕羅西汀聯合降糖藥物治療2型糖尿病療效觀察[J]. 國際醫藥衛生導報, 2012, 18(9):1253-1255.
16. 方桂興, 陸珍珍, 湯武. 生活方式干預與糖耐量異常[J]. 醫學綜述, 2010, 16(2):277-279.

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The Influence of Paroxetine on Blood Sugar and Endocrine of Pre-diabetes Patients Associated with Anxiety and Depression

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